儿童肺炎支原体肺炎肺外并发症的研究进展
Research Progress in Extrapulmonary Complications of Mycoplasma pneumoniae Pneumonia in Children
DOI: 10.12677/ACM.2023.134891, PDF,   
作者: 张 珊, 李渠北：重庆医科大学附属儿童医院呼吸科，重庆
关键词: 肺炎支原体；肺炎；肺外并发症；儿童；综述；Mycoplasma pneumoniae； Pneumonia； Extrapulmonary Complications； Children； Review
摘要: 肺炎支原体肺炎(MPP)是由肺炎支原体(MP)感染引起的一种常见的儿童社区获得性肺炎(CAP)，除引起呼吸系统相关症状外，还可以引起广泛的肺外系统表现，包括皮肤、中枢神经、心血管、血液、消化系统等，其中一部分可导致严重后果甚至死亡。提高对该类疾病的认识，早期识别并进行及时有效的治疗，改善其预后非常重要。本文综述讨论了儿童肺炎支原体肺炎各类型肺外并发症的研究进展，以便临床医师对该类疾病有更好的认识。
Abstract: Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia (CAP) in children caused by Mycoplasma pneumoniae (MP) infection. In addition to causing respiratory sys-tem-related symptoms, it can also cause a wide range of extrapulmonary manifestations, including skin, nerve, cardiovascular, blood, digestive system, etc., some of which can cause serious conse-quences or even death. It is very important to improve the understanding of this kind of disease, early identification and timely and effective treatment, and improve its prognosis. This article re-views and discusses the research progress in various types of extrapulmonary complications of My-coplasma pneumoniae pneumonia in children, so that clinicians can have a better understanding of this kind of disease.
文章引用：张珊, 李渠北. 儿童肺炎支原体肺炎肺外并发症的研究进展[J]. 临床医学进展, 2023, 13(4): 6335-6341. https://doi.org/10.12677/ACM.2023.134891

参考文献

[1] D’alonzo, R., Mencaroni, E., Di Genova, L., et al. (2018) Pathogenesis and Treatment of Neurologic Diseases Associat-ed with Mycoplasma pneumoniae Infection. Frontiers in Microbiology, 9, 2751. [Google Scholar] [CrossRef] [PubMed]
[2] Al-Zaidy, S.A., Macgregor, D., Mahant, S., et al. (2015) Neuro-logical Complications of PCR-Proven M. pneumoniae Infections in Children: Prodromal Illness Duration May Reflect Pathogenetic Mechanism. Clinical Infectious Diseases, 61, 1092-1098. [Google Scholar] [CrossRef] [PubMed]
[3] Daba, M., Kang, P.B., Sladky, J., et al. (2019) Intravenous Immunoglobulin as a Therapeutic Option for Mycoplasma pneumoniae Encephalitis. Journal of Child Neurology, 34, 687-691. [Google Scholar] [CrossRef] [PubMed]
[4] Talukder, N.T., Feezel, A. and Lankford, J.E. (2022) Mild En-cephalitis/Encephalopathy with a Reversible Splenial Lesion Associated with Systemic Mycoplasma pneumoniae Infec-tion in North America: A Case Report. Journal of Medical Case Reports, 16, 74. [Google Scholar] [CrossRef] [PubMed]
[5] Akbar, A. and Ahmad, S. (2021) Atypical Case of Mild Enceph-alopathy/Encephalitis with Reversible Splenial Lesion of the Corpus Callosum (MERS) Associated with Mycoplasma pneumoniae Infection in a Paediatric Patient. BMJ Case Reports, 14, e242791. [Google Scholar] [CrossRef] [PubMed]
[6] Salloum, S., Goenka, A. and Ey, E. (2019) Mycoplasma pneumonia Associated Transverse Myelitis Presenting as Asymmetric Flaccid Paralysis.Clinics and Practice, 9, 1142. [Google Scholar] [CrossRef] [PubMed]
[7] He, C.B., Lee, J.R. and Kahana, M. (2021) Mycoplasma pneumoniae Associated Acute Transverse Myelitis: An Atypical Clinical Presentation in an Adolescent Child. Cureus, 13, e17259. [Google Scholar] [CrossRef] [PubMed]
[8] Meyer Sauteur, P.M., Huizinga, R., Tio-Gillen, A.P., et al. (2018) In-trathecal Antibody Responses to GalC in Guillain- Barré Syndrome Triggered by Mycoplasma pneumoniae. Journal of Neuroimmunology, 314, 13-16. [Google Scholar] [CrossRef] [PubMed]
[9] Gaspari, E., Koehorst, J.J., Frey, J., et al. (2021) Galacto-cerebroside Biosynthesis Pathways of Mycoplasma Species: An Antigen Triggering Guillain-Barré-Stohl Syndrome. Microbial Biotechnology, 14, 1201-1211. [Google Scholar] [CrossRef] [PubMed]
[10] Jin, X., Zou, Y., Zhai, J., et al. (2018) Refractory Mycoplasma pneumoniae Pneumonia with Concomitant Acute Cerebral Infarction in a Child: A Case Report and Literature Review. Medicine (Baltimore), 97, e0103. [Google Scholar] [CrossRef] 
[11] Wang, Y., Xiao, Y., Deng, X., et al. (2021) Cardiac Throm-bus and Stroke in a Child with Mycoplasma pneumoniae Pneumonia: A Case Report. Medicine (Baltimore), 100, e24297. [Google Scholar] [CrossRef] 
[12] Kumaravel Kanagavelu, A.S., Nagumantry, S.K., Sagi, S.V., et al. (2022) A Rare Case of Severe Hemolytic Anemia and Pulmonary Embolism Secondary to Mycoplasma pneumoniae Infection. Journal of Medical Cases, 13, 119-124. [Google Scholar] [CrossRef] [PubMed]
[13] Wandro, C., Dolatshahi, L. and Blackall, D. (2018) Severe Warm Autoim-mune Hemolytic Anemia in a 7-Month-Old Infant Associated with a Mycoplasma pneumoniae Infection. Journal of Pe-diatric Hematology/Oncology, 40, e439- e441. [Google Scholar] [CrossRef] 
[14] Roshan, S. and Tan, S.W. (2020) A Case Report of Severe Mycoplasma Pneumonia with Autoimmune Haemolytic Anaemia. Medi-cal Journal of Malaysia, 75, 600-602.
[15] Han, C., Zhang, T., Zheng, J., et al. (2022) Analysis of the Risk Factors and Clinical Features of Mycoplasma pneumoniae Pneumonia with Embolism in Children: A Retrospective Study. Italian Journal of Pediatrics, 48, 153. [Google Scholar] [CrossRef] [PubMed]
[16] Liu, J., He, R., Wu, R., et al. (2020) Mycoplasma pneumoniae Pneumonia Associated Thrombosis at Beijing Children’s Hospital. BMC Infectious Diseases, 20, 51. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, J. and Li, Y. (2021) Thrombosis Associated with Mycoplas-ma pneumoniae Infection (Review). Experimental and Therapeutic Medicine, 22, 967. [Google Scholar] [CrossRef] [PubMed]
[18] Meyer Sauteur, P.M., Theiler, M., Buettcher, M., et al. (2020) Fre-quency and Clinical Presentation of Mucocutaneous Disease Due to Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia. JAMA Dermatology, 156, 144-150. [Google Scholar] [CrossRef] [PubMed]
[19] Canavan, T.N., Mathes, E.F., Frieden, I., et al. (2015) Myco-plasma pneumoniae-Induced Rash and Mucositis as a Syndrome Distinct from Stevens-Johnson Syndrome and Erythe-ma Multiforme: A Systematic Review. Journal of the American Academy of Dermatology, 72, 239-245. [Google Scholar] [CrossRef] [PubMed]
[20] Brazel, D., Kulp, B., Bautista, G., et al. (2021) Rash and Mucositis Associated with Mycoplasma pneumoniae and Chlamydophila pneumoniae: A Recurrence of MIRM? Journal of the Pe-diatric Infectious Diseases Society, 10, 220-224. [Google Scholar] [CrossRef] [PubMed]
[21] Curtiss, P., Melnick, L., Sicco, K.L., et al. (2018) Mycoplasma pneu-moniae, More than a Lung Disease. Dermatology Online Journal, 24, Article No. 21. [Google Scholar] [CrossRef] 
[22] Lofgren, D. and Lenkeit, C. (2021) Mycoplasma pneumoniae-Induced Rash and Mucositis: A Systematic Review of the Literature. Spartan Medical Research Journal, 6, 25284. [Google Scholar] [CrossRef] [PubMed]
[23] Olson, D., Watkins, L.K., Demirjian, A., et al. (2015) Outbreak of My-coplasma pneumoniae-Associated Stevens-Johnson Syndrome. Pediatrics, 136, e386-e394. [Google Scholar] [CrossRef] [PubMed]
[24] Campagna, C., Tassinari, D., Neri, I., et al. (2013) Mycoplasma pneumoniae-Induced Recurrent Stevens-Johnson Syndrome in Children: A Case Report. Pediatric Dermatology, 30, 624-626. [Google Scholar] [CrossRef] [PubMed]
[25] Watkins, L.K.F., Olson, D., Diaz, M.H., et al. (2017) Epidemiol-ogy and Molecular Characteristics of Mycoplasma pneumoniae during an Outbreak of M. pneumoniae-Associated Ste-vens-Johnson Syndrome. The Pediatric Infectious Disease Journal, 36, 564-571. [Google Scholar] [CrossRef] 
[26] Amode, R., Ingen-Housz-Oro, S., Ortonne, N., et al. (2018) Clinical and Histologic Features of Mycoplasma pneumoniae-Related Erythema Multiforme: A Single-Center Series of 33 Cases Compared with 100 Cases Induced by Other Causes. Journal of the American Academy of Dermatology, 79, 110-117. [Google Scholar] [CrossRef] [PubMed]
[27] Langley, A., Anooshiravani, N., Kwan, S., et al. (2016) Erythema Multiforme in Children and Mycoplasma pneumoniae Aetiology. Journal of Cutaneous Medicine and Surgery, 20, 453-457. [Google Scholar] [CrossRef] [PubMed]
[28] 陈志敏, 尚云晓, 赵顺英, 等. 儿童肺炎支原体肺炎诊治专家共识(2015年版) [J]. 中华实用儿科临床杂志, 2015, 30(17): 1304-1308.
[29] Waites, K.B., Xiao, L., Liu, Y., et al. (2017) Mycoplasma pneumoniae from the Respiratory Tract and beyond. Clinical Microbiology Reviews, 30, 747-809. [Google Scholar] [CrossRef] 
[30] Fan, Q., Meng, J., Li, P., et al. (2015) Pathogenesis and Association of Mycoplasma pneumoniae Infection with Cardiac and Hepatic Damage. Microbiology and Immunology, 59, 375-380. [Google Scholar] [CrossRef] [PubMed]
[31] Rao, H., Ericson, J.E. and O’hara, C. (2020) Myco-plasma pneumoniae Presenting with Pericardial Tamponade. Clinical Pediatrics (Phila), 59, 198-200. [Google Scholar] [CrossRef] [PubMed]
[32] 李奇蕊, 袁越, 林利, 等. 肺炎支原体肺炎并发心腔内血栓二例[J]. 中华儿科杂志, 2018, 56(12): 950-951.
[33] Jujaray, D., Juan, L.Z., Shrestha, S., et al. (2018) Pattern and Sig-nificance of Asymptomatic Elevation of Liver Enzymes in Mycoplasma Pneumonia in Children. Clinical Pediatrics (Phi-la), 57, 57-61. [Google Scholar] [CrossRef] [PubMed]
[34] Bi, Y., Ma, Y., Zhuo, J., et al. (2021) Risk of Mycoplasma pneumoniae-Related Hepatitis in MP Pneumonia Pediatric Patients: A Predictive Model Construction and Assessment. BMC Pediatrics, 21, 287. [Google Scholar] [CrossRef] [PubMed]
[35] Poddighe, D. (2020) Mycoplasma pneumoniae-Related Hepatitis in Children. Microbial Pathogenesis, 139, Article ID: 103863. [Google Scholar] [CrossRef] [PubMed]
[36] Graf, G., Vassalli, G.A.M., Kottanattu, L., et al. (2022) Acute Pancreatitis Associated with Atypical Bacterial Pneumonia: Systematic Literature Review. Journal of Clinical Medicine, 11, 7248. [Google Scholar] [CrossRef] [PubMed]
[37] Valdés Lacasa, T., Duarte Borges, M.A., García Marín, A., et al. (2017) Acute Pancreatitis Caused by Mycoplasma pneumoniae: An Unusual Etiology. Clinical Journal of Gastroen-terology, 10, 279-282. [Google Scholar] [CrossRef] [PubMed]
[38] Khan, H.R.A., Singh, A., Usman, O., et al. (2022) Acute Pancre-atitis: An Unusual Extrapulmonary Manifestation of Mycoplasma pneumoniae. Cureus, 14, e25052. [Google Scholar] [CrossRef] [PubMed]
[39] Mărginean, C.O., Georgescu, A.M. and Meliţ, L.E. (2021) Arthritis Associated with Mycoplasma pneumoniae in a Pediatric Patient: A Case Report. Medicine (Baltimore), 100, e24316. [Google Scholar] [CrossRef] 
[40] Chen, Y., Huang, Z., Fang, X., et al. (2020) Diagnosis and Treatment of Mycoplasmal Septic Arthritis: A Systematic Review. International Orthopaedics, 44, 199-213. [Google Scholar] [CrossRef] [PubMed]
[41] Kc, O., Dahal, P.H., Koirala, M., et al. (2021) Rhabdomyolysis and Neurological Manifestation with Progressive Weakness in a Young Adult: A Rare Extrapulmonary Presentation of Mycoplasma pneumoniae. Cureus, 13, e20552. [Google Scholar] [CrossRef] [PubMed]
[42] Szugye, H.S. (2020) Pediatric Rhabdomyolysis. Pediatrics in Review, 41, 265-275. [Google Scholar] [CrossRef] [PubMed]
[43] Simoni, C., Camozzi, P., Faré, P.B., et al. (2020) Myositis and Acute Kidney Injury in Bacterial Atypical Pneumonia: Systematic Literature Review. Journal of Infection and Public Health, 13, 2020-2024. [Google Scholar] [CrossRef] [PubMed]
[44] Aizawa, T., Watanabe, S., Tsugawa, K., et al. (2021) Membranous Nephropathy Associated with Mycoplasma pneumoniae Infection. Pediatrics International, 63, 853-855. [Google Scholar] [CrossRef] [PubMed]

为你推荐