血清糖化白蛋白、同型半胱氨酸水平与急性脑梗死严重程度的相关性分析

Correlation Analysis of Serum Glycated Albumin, Homocysteine Levels and the Severity of Acute Cerebral Infarction

摘要: 目的：探讨急性脑梗死(ACI)患者血清中糖化白蛋白(GA)、同型半胱氨酸(Hcy)水平在脑梗死中的影响。方法：选取来我院神经内科就诊的首次发作ACI患者195例，以NHISS评分为分组依据，分为正常或近乎正常组63例(NIHSS评分0~1分)、轻度卒中/小卒中83例(NIHSS评分2~4分)、中–重度组49例(NIHSS评分 ≥ 5分)。比较不同NIHSS评分组患者入院时血清GA、Hcy水平，评估GA、Hcy水平两者之间关系及两者与NIHSS评分之间关系。结果：GA水平与Hcy水平之间存在明显正相关(r = 0.319, P < 0.05)；NIHSS评分与GA、Hcy水平之间经Spearman相关性分析结果显示，NIHSS评分与GA之间存在明显的正相关(r = 0.438, P < 0.05)，NIHSS评分与Hcy之间存在明显的正相关(r = 0.377, P < 0.05)。有序Logistic回归分析GA、Hcy与ACI患者神经功能缺损有显著关联性，而且还是独立危险因素。结论：血清GA水平越高，Hcy水平越高。血清GA、Hcy水平是ACI患者神经功能缺损的危险因素。

Abstract: Objective: To investigate the effect of glycated albumin (GA) and homocysteine (Hcy) levels in cere-bral infarction in patients with acute cerebral infarction (ACI). Methods: 195 patients with first on-set ACI in our hospital were divided into 63 normal or near-normal group (NIHSS score 0~1), 83 mild stroke/minor stroke (NIHSS score 2~4), and 49 moderate-severe group (NIHSS score 5). Com-pared the serum GA and Hcy levels at admission in different NIHSS score groups, and evaluated the relationship between GA and Hcy levels and the relationship between both and NIHSS score. Results showed clear positive correlation between GA level and Hcy level (r = 0.319, P < 0.05); Spearman correlation between NIHSS score and GA and Hcy level showed significant positive correlation be-tween NIHSS score and GA (r = 0.438, P < 0.05) and significant positive correlation between NIHSS score and Hcy (r = 0.377, P < 0.05). Original Logistic regression analysis GA and Hcy showed signifi-cant associations with neurological deficit in ACI patients and were independent risk factors. Con-clusion: The higher the serum GA level, the higher the Hcy. Serum GA and Hcy levels are risk factors for neurological deficit in ACI patients.