促泌素在糖尿病中的研究进展
Research Progress of Secretagogin in Diabetes Mellitus
DOI: 10.12677/ACM.2023.134967, PDF,   
作者: 史嘉琳, 吴乃君*, 王志新, 张妍妍:华北理工大学附属医院内分泌科,河北 唐山
关键词: 促泌素钙调蛋白胰岛细胞糖尿病Secretagogin Calmodulin Islet Cells Diabetes Mellitus
摘要: 促泌素是一种新型钙调节蛋白,在全身各器官系统均有表达,在应激反应、神经内分泌肿瘤等中的作用被广泛关注。有研究发现,促泌素高表达于胰岛β细胞,其参与胰岛素分泌、胰岛细胞增殖等。本文总结相关文献内容,介绍促泌素在糖尿病发生发展中的研究进展,为进一步临床研究提供相关依据。
Abstract: Secretagogin is a novel calmodulin, which is expressed in various organ systems throughout the body, and role in stress response and neuroendocrine tumors has been widely concerned. Studies have found that secretagogin is highly expressed in islet beta cells, which is involved in insulin se-cretion, islet cell proliferation and so on. In this paper, relevant literature is summarized to intro-duce the research progress of cretin in the occurrence and development of diabetes mellitus, so as to provide relevant evidence for further clinical research.
文章引用:史嘉琳, 吴乃君, 王志新, 张妍妍. 促泌素在糖尿病中的研究进展[J]. 临床医学进展, 2023, 13(4): 6905-6910. https://doi.org/10.12677/ACM.2023.134967

参考文献

[1] Cho, N.H., Shaw, J.E., Karuranga, S., et al. (2018) IDF Diabetes Atlas: Global Estimates of Diabetes Prevalence for 2017 and Projections for 2045. Diabetes Research and Clinical Practice, 138, 271-281. [Google Scholar] [CrossRef] [PubMed]
[2] Sun, H., Saeedi, P., Karuranga, S., et al. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Research and Clinical Practice, 183, Article ID: 109119. [Google Scholar] [CrossRef] [PubMed]
[3] Wagner, L., Oliyarnyk, O., Gartner, W., et al. (2000) Cloning and Expression of Secretagogin, a Novel Neuroendocrine- and Pancreatic Islet of Langerhans-Specific Ca2+-Binding Protein. Journal of Biological Chemistry, 275, 24740- 24751. [Google Scholar] [CrossRef
[4] Tan, W.S.D., Lee, J.J., Satish, R.L., et al. (2012) Detectability of Secretagogin in Human Erythrocytes. Neuroscience Letters, 526, 59-62. [Google Scholar] [CrossRef] [PubMed]
[5] Zierhut, B., Daneva, T., Gartner, W., et al. (2005) Setagin and Secretagogin-R22: Posttranscriptional Modification Products of the Secretagogin Gene. Biochemical and Bi-ophysical Research Communications, 329, 1193-1199. [Google Scholar] [CrossRef] [PubMed]
[6] Lai, M., Lü, B., Xing, X., et al. (2006) Secretagogin, a Novel Neuroendocrine Marker, Has a Distinct Expression Pattern from Chromogranin A. Virchows Archiv, 449, 402-409. [Google Scholar] [CrossRef] [PubMed]
[7] Puthussery, T., Gayet-Primo, J. and Taylor, W.R. (2010) Locali-zation of the Calcium-Binding Protein Secretagogin in Cone Bipolar Cells of the Mammalian Retina. Journal of Compar-ative Neurology, 518, 513-525. [Google Scholar] [CrossRef] [PubMed]
[8] Berggård, T., Miron, S., Onnerfjord, P., et al. (2002) Calbindin D28k Ex-hibits Properties Characteristic of a Ca2+ Sensor. Journal of Biological Chemistry, 277, 16662-16672. [Google Scholar] [CrossRef
[9] Schwaller, B., Durussel, I., Jermann, D., et al. (1997) Comparison of the Ca2+-Binding Properties of Human Recombinant Calretinin-22k and Calretinin. Journal of Biological Chemistry, 272, 29663-29671. [Google Scholar] [CrossRef] [PubMed]
[10] Lee, J.J., Yang, S.Y., Park, J., et al. (2017) Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function. Scien-tific Reports, 7, Article No. 6976. [Google Scholar] [CrossRef] [PubMed]
[11] Rorsman, P., Eliasson, L., Renstrom, E., et al. (2000) The Cell Physiology of Biphasic Insulin Secretion. Physiology, 15, 72-77. [Google Scholar] [CrossRef] [PubMed]
[12] Rorsman, P. and Renström, E. (2003) Insulin Granule Dynamics in Pancreatic Beta Cells. Diabetologia, 46, 1029-1045. [Google Scholar] [CrossRef] [PubMed]
[13] Nevins, A.K. and Thurmond, D.C. (2003) Glucose Regulates the Cortical Actin Network through Modulation of Cdc42 Cycling to Stimulate Insulin Secretion. American Journal of Physiology-Cell Physiology, 285, C698-C710. [Google Scholar] [CrossRef] [PubMed]
[14] Henquin, J.C., Mourad, N.I. and Nenquin, M. (2012) Disruption and Stabilization of β-Cell Actin Microfilaments Differently Influence Insulin Secretion Triggered by Intracellular Ca2+ Mobilization or Store-Operated Ca2+ Entry. FEBS Letters, 586, 89-95. [Google Scholar] [CrossRef] [PubMed]
[15] Rondas, D., Tomas, A. and Halban, P.A. (2011) Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin. Diabetes, 60, 1146-1157. [Google Scholar] [CrossRef] [PubMed]
[16] Rondas, D., Tomas, A., Soto-Ribeiro, M., et al. (2012) Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-Stimulated Insulin Secretion. Journal of Biological Chemistry, 287, 2423-2436. [Google Scholar] [CrossRef
[17] Rogstam, A., Linse, S., Lindqvist, A., et al. (2007) Binding of Cal-cium Ions and SNAP-25 to the Hexa EF-Hand Protein Secretagogin. Biochemical Journal, 401, 353-363. [Google Scholar] [CrossRef
[18] Chen, Y.A. and Scheller, R.H. (2001) SNARE-Mediated Membrane Fu-sion. Nature Reviews Molecular Cell Biology, 2, 98-106. [Google Scholar] [CrossRef] [PubMed]
[19] Poirier, M.A., Xiao, W., Macosko, J.C., et al. (1998) The Synaptic SNARE Complex Is a Parallel Four-Stranded Helical Bundle. Na-ture Structural Biology, 5, 765-769. [Google Scholar] [CrossRef] [PubMed]
[20] Sutton, R.B., Fasshauer, D., Jahn, R., et al. (1998) Crystal Structure of a SNARE Complex Involved in Synaptic Exocytosis at 2.4 Å Resolution. Nature, 395, 347-353. [Google Scholar] [CrossRef] [PubMed]
[21] Qin, J., Liu, Q., Liu, Z., et al. (2020) Structural and Mechanistic In-sights into Secretagogin-Mediated Exocytosis. Proceedings of the National Academy of Sciences, 117, 6559-6570. [Google Scholar] [CrossRef] [PubMed]
[22] Müller, T.D., Finan, B., Bloom, S.R., et al. (2019) Glucagon-Like Peptide 1 (GLP-1). Molecular Metabolism, 30, 72-130. [Google Scholar] [CrossRef] [PubMed]
[23] Biancolin, A.D., Jeong, H., Mak, K.W.Y., et al. (2022) Dis-rupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of type 2 Diabetes. Endocrinol-ogy, 163, bqac118. [Google Scholar] [CrossRef] [PubMed]
[24] Hansson, S.F., Zhou, A.X., Vachet, P., et al. (2018) Secretagogin Is Increased in Plasma from Type 2 Diabetes Patients and Potentially Reflects Stress and Islet Dys-function. PLOS ONE, 13, e0196601. [Google Scholar] [CrossRef] [PubMed]
[25] 杨靖, 赵志波, 吴丽, 项孙敏, 李骄阳, 颜斌, 肖新华. 胰岛素强化治疗对新发2型糖尿病非肥胖患者血浆促泌素的影响[J]. 实用医学杂志, 2019, 35(8): 1288-1291.
[26] Yang, C., Qu, H., Zhao, X., et al. (2021) Plasma Secretagogin Is Increased in Individuals with Glucose Dysregulation. Experimental and Clinical Endocrinology & Diabetes, 129, 661-665. [Google Scholar] [CrossRef] [PubMed]
[27] Deischinger, C., Harreiter, J., Leitner, K., et al. (2020) Secretagogin Is Related to Insulin Secretion but Unrelated to Gestational Diabetes Mellitus Status in Pregnancy. Journal of Clinical Med-icine, 9, 2277. [Google Scholar] [CrossRef] [PubMed]
[28] Xu, Y., Toomre, D.K., Bogan, J.S., et al. (2017) Excess Cholesterol In-hibits Glucose-Stimulated Fusion Pore Dynamics in Insulin Exocytosis. Journal of Cellular and Molecular Medicine, 21, 2950-2962. [Google Scholar] [CrossRef] [PubMed]
[29] Bogan, J.S., Xu, Y. and Hao, M. (2012) Cholesterol Accumulation In-creases Insulin Granule Size and Impairs Membrane Trafficking. Traffic, 13, 1466-1480. [Google Scholar] [CrossRef] [PubMed]
[30] Kong, F.J., Wu, J.H., Sun, S.Y., et al. (2017) The Endo-plasmic Reticulum Stress/Autophagy Pathway Is Involved in Cholesterol-Induced Pancreatic β-Cell Injury. Scientific Re-ports, 7, Article No. 44746. [Google Scholar] [CrossRef] [PubMed]
[31] Kataoka, H.U. and Noguchi, H. (2013) ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation. Cell Medicine, 5, 53-57. [Google Scholar] [CrossRef
[32] Yang, J., Lv, Y., Zhao, Z., et al. (2019) A mi-croRNA-24-to-Secretagogin Regulatory Pathway Mediates Cholesterol-Induced Inhibition of Insulin Secretion. Interna-tional Journal of Molecular Medicine, 44, 608-616. [Google Scholar] [CrossRef] [PubMed]
[33] Hasegawa, K., Wakino, S., Kimoto, M., et al. (2013) The Hydrolase DDAH2 Enhances Pancreatic Insulin Secretion by Transcriptional Regulation of Secretagogin through a Sirt1-Dependent Mechanism in Mice. The FASEB Journal, 27, 2301-2315. [Google Scholar] [CrossRef] [PubMed]
[34] Malenczyk, K., Girach, F., Szodorai, E., et al. (2017) A TRPV 1-to-Secretagogin Regulatory Axis Controls Pancreatic β-Cell Survival by Modulating Protein Turnover. The EMBO Journal, 36, 2107-2125. [Google Scholar] [CrossRef] [PubMed]
[35] Sharma, A.K., Khandelwal, R., Kumar, M.J.M., et al. (2019) Se-cretagogin Regulates Insulin Signaling by Direct Insulin Binding. Iscience, 21, 736-753. [Google Scholar] [CrossRef] [PubMed]