中药防治抑郁症的研究进展
Research Progress of Depression Prevention and Treatment with Chinese Medicine
DOI: 10.12677/ACM.2023.134975, PDF,    国家自然科学基金支持
作者: 朱 晗, 段学清, 朱 晨, 田维毅*：贵州中医药大学基础医学院，贵州 贵阳
关键词: 抑郁症；中药；机制；Depression； Traditional Chinese Medicine； Mechanism
摘要: 抑郁症是一种常见且严重的精神疾病，临床表现为情绪低落、思维迟缓、意志活动、减退嗜睡、食欲减退、疲劳乏力、性欲减退、失眠等，甚者自杀。其患者的功能残疾程度高于糖尿病、高血压、冠状动脉疾病或关节炎等慢性疾病患者。预计到2030年抑郁症成为世界第二大疾病。目前抑郁症的发病机制尚未定论。临床以西药为主的抗抑郁药，出现时效长，疗效差，副作用明显等问题。而中药在中医辨证与整体的指导思路下，因多靶点、多途径、整体调节且不良反应小的特点，医生和患者逐渐接受中医药治疗。本文主要探讨抑郁症在常用中药的组方、单药和中药提取化合物的治疗方面的研究进展，为未来对其进行深入研究可为抗抑郁治疗提供新思路。
Abstract: Depression is a common and serious mental disease, with clinical manifestations such as depressed mood, slow thinking, willpower activity, decreased drowsiness, decreased appetite, fatigue, de-creased libido, insomnia, and even suicide. Their patients had a higher degree of functional disabil-ity than those with chronic conditions such as diabetes, hypertension, coronary artery disease or arthritis. Depression is expected to become the world’s second largest disease by 2030. At present, the pathogenesis of depression has not yet been determined. Antidepressants, which are mainly western medicine in clinic, have such problems as long time effect, poor curative effect, obvious side effects, etc. Under the guidance of TCM syndrome differentiation and holism, doctors and patients of traditional Chinese medicine (TCM) are gradually receiving TCM treatment due to the characteris-tics of multiple targets, multiple pathways, overall regulation and small adverse reactions. This pa-per mainly discusses the research progress of depression in the treatment of commonly used tradi-tional Chinese medicine (TCM) formula, single drug and Chinese medicine extract compounds, to provide new ideas for further research and antidepressant treatment in the future.
文章引用：朱晗, 段学清, 朱晨, 田维毅. 中药防治抑郁症的研究进展[J]. 临床医学进展, 2023, 13(4): 6960-6975. https://doi.org/10.12677/ACM.2023.134975

参考文献

[1] Stöckl, T. and Hillemacher, T. (2021) Verdacht auf Depression [Depression in Young Woman]. MMW-Fortschritte der Medizin, 63, 40-41. (In German) [Google Scholar] [CrossRef] [PubMed]
[2] Lu, J., Xu, X., Huang, Y., Li, T., Ma, C., Xu, G., Yin, H., Xu, X., Ma, Y., Wang, L., Huang, Z., Yan, Y., Wang, B., Xiao, S., Zhou, L., Li, L., Zhang, Y., Chen, H., Zhang, T., Yan, J., Ding, H., Yu, Y., Kou, C., Shen, Z., Jiang, L., Wang, Z., Sun, X., Xu, Y., He, Y., Guo, W., Jiang, L., Li, S., Pan, W., Wu, Y., Li, G., Jia, F., Shi, J., Shen, Z. and Zhang, N. (2021) Prevalence of Depressive Dis-orders and Treatment in China: A Cross-Sectional Epidemiological Study. Lancet Psychiatry, 8, 981-990. [Google Scholar] [CrossRef] 
[3] Kang, C. and Yang, J. (2022) Prevalence of Mental Disor-ders in China. Lancet Psychiatry, 9, 13. [Google Scholar] [CrossRef] 
[4] Lim, G. (2021) Perinatal Depression. Current Opinion in Anaesthesiology, 34, 233-237. [Google Scholar] [CrossRef] 
[5] Swetlitz, N. (2021) Depression’s Problem with Men. AMA Journal of Ethics, 23, 586-589. [Google Scholar] [CrossRef] [PubMed]
[6] Leichsenring, F., Luyten, P., Abbass, A., Rabung, S. and Steinert, C. (2021) Treatment of Depression in Children and Adolescents. Lancet Psychiatry, 8, 96-97. [Google Scholar] [CrossRef] 
[7] van den Berg, K.S., Wiersema, C., Hegeman, J.M., van den Brink, R.H.S., Rhebergen, D., Marijnissen, R.M. and Oude Voshaar, R.C. (2021) Clinical Characteristics of Late-Life Depression Predicting Mortality. Aging & Mental Health, 25, 476-483. [Google Scholar] [CrossRef] [PubMed]
[8] Lopez, R., Barateau, L., Evangelista, E. and Dauvilliers, Y. (2017) Depression and Hypersomnia: A Complex Association. Sleep Medicine Clinics, 12, 395-405. [Google Scholar] [CrossRef] [PubMed]
[9] Kubon, J., Sokolov, A.N., Popp, R., Fallgatter, A.J. and Pavlova, M.A. (2021) Face Tuning in Depression. Cerebral Cortex, 31, 2574-2585. [Google Scholar] [CrossRef] [PubMed]
[10] Bhatt, S., Devadoss, T., Manjula, S.N. and Rajangam, J. (2021) 5-HT3 Receptor Antagonism: A Potential Therapeutic Approach for the Treatment of Depression and Other Disorders. Current Neuropharmacology, 19, 1545-1559. [Google Scholar] [CrossRef] 
[11] Spellman, T. and Liston, C. (2020) Toward Circuit Mechanisms of Pathophysiology in Depression. American Journal of Psychiatry, 177, 381-390. [Google Scholar] [CrossRef] [PubMed]
[12] Jesulola, E., Micalos, P. and Baguley, I.J. (2018) Under-standing the Pathophysiology of Depression: From Monoamines to the Neurogenesis Hypothesis Model—Are We There Yet? Behavioural Brain Research, 341, 79-90. [Google Scholar] [CrossRef] [PubMed]
[13] Beurel, E., Toups, M. and Nemeroff, C.B. (2020) The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron, 107, 234-256. [Google Scholar] [CrossRef] [PubMed]
[14] Halaris, A. (2019) Inflammation and Depression but Where Does the Inflammation Come from? Current Opinion in Psychiatry, 32, 422-428. [Google Scholar] [CrossRef] 
[15] Jia, X., Gao, Z. and Hu, H. (2021) Microglia in Depression: Current Perspectives. Science China Life Sciences, 64, 911-925. [Google Scholar] [CrossRef] [PubMed]
[16] Deng, S.-L., Chen, J.-G. and Wang, F. (2020) Microglia: A Cen-tral Player in Depression. Current Medical Science, 40, 391-400. [Google Scholar] [CrossRef] [PubMed]
[17] Peirce, J.M. and Alviña, K. (2019) The Role of Inflammation and the Gut Microbiome in Depression and Anxiety. Journal of Neuroscience Research, 97, 1223-1241. [Google Scholar] [CrossRef] [PubMed]
[18] Trzeciak, P. and Herbet, M. (2021) Role of the Intestinal Microbiome, Intes-tinal Barrier and Psychobiotics in Depression. Nutrients, 13, Article No. 927. [Google Scholar] [CrossRef] [PubMed]
[19] Simpson, C.A., Diaz-Arteche, C., Eliby, D., Schwartz, O.S., Simmons, J.G. and Cowan, C.S.M. (2021) The Gut Microbiota in Anxiety and Depression—A Systematic Review. Clinical Psy-chology Review, 83, Article ID: 101943. [Google Scholar] [CrossRef] [PubMed]
[20] Cruz-Pereira, J.S., Rea, K., Nolan, Y.M., O’Leary, O.F., Dinan, T.G. and Cryan, J.F. (2020) Depression’s Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. Annual Review of Psychology, 71, 49-78. [Google Scholar] [CrossRef] [PubMed]
[21] Castrén, E. and Monteggia, L.M. (2021) Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action. Biological Psychiatry, 90, 128-136. [Google Scholar] [CrossRef] [PubMed]
[22] Rahmani, M., Rahmani, F. and Rezaei, N. (2020) The Brain-Derived Neurotrophic Factor: Missing Link between Sleep Deprivation, Insomnia, and Depression. Neuro-chemical Research, 45, 221-231. [Google Scholar] [CrossRef] [PubMed]
[23] Meng, F., Liu, J., Dai, J., Wu, M., Wang, W., Liu, C., Zhao, D., Wang, H., Zhang, J., Li, M. and Li, C. (2020) Brain-Derived Neurotrophic Factor in 5-HT Neurons Regulates Suscepti-bility to Depression-Related Behaviors Induced by Subchronic Unpredictable Stress. Journal of Psychiatric Research, 126, 55-66. [Google Scholar] [CrossRef] [PubMed]
[24] Malhi, G.S. and Mann, J.J. (2018) Depression. Lancet, 392, 2299-2312. [Google Scholar] [CrossRef] 
[25] Ferrari, F. and Villa, R.F. (2017) The Neurobiology of De-pression: an Integrated Overview from Biological Theories to Clinical Evidence. Molecular Neurobiology, 54, 4847-4865. [Google Scholar] [CrossRef] [PubMed]
[26] Bingham, K.S., Mulsant, B.H., Dawson, D.R., Banerjee, S. and Flint, A.J. (2021) Relationship of Hair Cortisol with History of Psychosis, Neuropsychological Performance and Func-tioning in Remitted Later-Life Major Depression. Neuropsychobiology, 80, 313-320. [Google Scholar] [CrossRef] [PubMed]
[27] Kinlein, S.A., Phillips, D.J., Keller, C.R. and Karatsoreos, I.N. (2019) Role of Corticosterone in Altered Neurobehavioral Responses to Acute Stress in a Model of Compromised Hypothalam-ic-Pituitary-Adrenal Axis Function. Psychoneuroendocrinology, 102, 248-255. [Google Scholar] [CrossRef] [PubMed]
[28] Juruena, M.F., Gadelrab, R., Cleare, A.J. and Young, A.H. (2021) Epigenetics: A Missing Link between Early Life Stress and Depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 109, Article ID: 110231. [Google Scholar] [CrossRef] [PubMed]
[29] Lin, E. and Tsai, S.-J. (2019) Epigenetics and Depression: An Update. Psychiatry Investigation, 16, 654-661. [Google Scholar] [CrossRef] [PubMed]
[30] Park, C., Rosenblat, J.D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A. and McIntyre, R.S. (2019) Stress, Epigenetics and Depression: A Systematic Review. Neuroscience & Biobehavioral Reviews, 102, 139-152. [Google Scholar] [CrossRef] [PubMed]
[31] Kverno, K.S. and Mangano, E. (2021) Treatment-Resistant Depression: Approaches to Treatment. Journal of Psychosocial Nursing and Mental Health Services, 59, 7-11. [Google Scholar] [CrossRef] [PubMed]
[32] Marom, A. and Rosca, P. (2021) [Esketamine for Treatment Resistant Depression: Research and Risk Management]. Harefuah, 160, 372-376.( In Hebrew)
[33] Sabella, D. (2018) Antidepressant Medications. American Journal of Nursing, 118, 52-59. [Google Scholar] [CrossRef] 
[34] Hebel, T., Schecklmann, M. and Langguth, B. (2020) Transcranial Magnetic Stimulation in the Treatment of Depression during Pregnancy: A Review. Archives of Women’s Mental Health, 23, 469-478. [Google Scholar] [CrossRef] [PubMed]
[35] Zorn, A., Linn, S., Jenkinson, M., Neher, J.O., Safranek, S. and Kelsberg, G. (2021) Is Ketamine Effective and Safe for Treatment-Resistant Depression? The Journal of Family Practice, 70, E1-E3. [Google Scholar] [CrossRef] [PubMed]
[36] 袁霞红, 刘林. 肠道菌群调节抑郁症机制及中医药防治研究进展[J]. 中华中医药学刊, 2022, 40(9): 167-170. http://kns.cnki.net/kcms/detail/21.1546.R.20220304.1252.018.html
[37] 宁婕, 王新, 马柯. 经典名方治疗抑郁症的临床研究现状与规律[J]. 中华中医药学刊, 2022, 40(8): 108-111. http://kns.cnki.net/kcms/detail/21.1546.R.20220106.1754.004.html
[38] 亓新庆, 亓雪梅, 刘甜梦, 粟栗. 从虚论治抑郁症方药研究进展[J]. 中国实验方剂学杂志, 2021, 27(17): 217-226. [Google Scholar] [CrossRef] 
[39] Ren, L. and Chen, G. (2017) Rapid Antidepressant Effects of Yueju: A New Look at the Function and Mechanism of an Old Herbal Medicine. Journal of Ethnopharmacology, 203, 226-232. [Google Scholar] [CrossRef] [PubMed]
[40] Zhang, Y., Fang, Y.-C., Cui, L.-X., Jiang, Y.-T., Luo, Y.-S., Zhang, W., Yu, D.-X., Wen, J. and Zhou, T.-T. (2022) Zhi-Zi-Chi Decoction Reverses Depressive Behaviors in CUMS Rats by Reducing Oxidative Stress Injury Via Regulating GSH/GSSG Pathway. Frontiers in Pharmacology, 13, Article 887890. [Google Scholar] [CrossRef] [PubMed]
[41] Qu, S., Liu, M., Cao, C., Wei, C., Meng, X.-E., Lou, Q., Wang, B., Li, X., She, Y., Wang, Q., Song, Z., Han, Z., Zhu, Y., Huang, F. and Duan, J.-A. (2021) Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-Like Mice and Reduces the Expres-sions of Inflammatory Factors via Inhibiting TLR4/ IKK/NF-κB Pathways on BV2 Cells. Frontiers in Pharmacology, 12, Article 626949. [Google Scholar] [CrossRef] [PubMed]
[42] Zhang, S., Lu, Y., Chen, W., Shi, W., Zhao, Q., Zhao, J. and Li, L. (2021) Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway Is Involved in the Antide-pressive Roles of Chaihu Shugan San. Drug Design, Development and Therapy, 15, 3425-3441. [Google Scholar] [CrossRef] 
[43] Chen, G., Feng, P., Wang, S., Ding, X., Xiong, J., Wu, J., Wang, L., Chen, W., Chen, G., Han, M., Zou, T., Li, L. and Du, H. (2020) An Herbal Formulation of Jiawei Xiaoyao for the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Placebo-Controlled, Clinical Trial. Clinical and Trans-lational Gastroenterology, 11, e00241. [Google Scholar] [CrossRef] [PubMed]
[44] Wang, M., Huang, W., Gao, T., Zhao, X. and Lv, Z. (2018) Effects of Xiao Yao San on Interferon-α-Induced Depression in Mice. Brain Research Bulletin, 139, 197-202. [Google Scholar] [CrossRef] [PubMed]
[45] Zhu, H.-Z., Liang, Y.-D., Ma, Q.-Y., Hao, W.-Z., Li, X.-J., Wu, M.-S., Deng, L.-J., Li, Y.-M. and Chen, J.-X. (2019) Xiaoyaosan Improves Depressive-Like Behavior in Rats with Chronic Immobilization Stress through Modulation of the Gut Microbiota. Biomedicine & Pharmacotherapy, 112, Article ID: 108621. [Google Scholar] [CrossRef] [PubMed]
[46] Lv, M., Wang, Y., Qu, P., Li, S., Yu, Z., Qin, X. and Liu, X. (2021) A Combination of Cecum Microbiome and Metabolome in CUMS Depressed Rats Reveals the Antidepressant Mechanism of Traditional Chinese Medicines: A Case Study of Xiaoyaosan. Journal of Ethnopharmacology, 276, Arti-cle ID: 114167. [Google Scholar] [CrossRef] [PubMed]
[47] Xia, Z., Zhang, C., Du, Y., Huang, W., Xing, Z., Cao, H., Nie, K., Wang, Y., Xiong, X. and Yang, B. (2019) The Effect of Traditional Chinese Medicine Zhike-Houpu Herbal Pair on De-pressive Behaviors and Hippocampal Serotonin 1A Receptors in Rats after Chronic Unpredictable Mild Stress. Psycho-somatic Medicine, 81, 100-109. [Google Scholar] [CrossRef] 
[48] 赵洪庆, 刘检, 孟盼, 杨蕙, 蔺晓源, 龙红萍, 余曦明, 王宇红. 百合地黄汤对焦虑性抑郁症模型大鼠海马突触可塑性的影响[J]. 中国中药杂志, 2021, 46(5): 1205-1210. [Google Scholar] [CrossRef] [PubMed]
[49] Xue, X., Pan, J., Zhang, H., Lu, Y., Mao, Q. and Ma, K. (2022) Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) Decoction Attenuates Somatostatin Interneurons Deficits in Prefrontal Cortex of Depression via miRNA-144-3p Mediated GABA Synthesis and Release. Journal of Ethnopharmacology, 292, Article ID: 115218. [Google Scholar] [CrossRef] [PubMed]
[50] Zhang, L., Li, J., Chen, Q., Di, L. and Li, N. (2021) Erxian Decoc-tion, a Famous Chinese Medicine Formula, Ameliorate Depression-Like Behavior in Perimenopausal Mice. Endocrine, Metabolic & Immune Disorders-Drug Targets, 21, 2203-2212. [Google Scholar] [CrossRef] [PubMed]
[51] Jing, W., Song, S., Sun, H., Chen, Y., Zhao, Q., Zhang, Y., Dai, G. and Ju, W. (2019) Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis. Neural Plasticity, 2019, Article ID: 1571392. [Google Scholar] [CrossRef] [PubMed]
[52] Wang, X., Chen, J., Zhang, H., Huang, Z., Zou, Z., Chen, Y., Sheng, L., Xue, W., Tang, J., Wu, H., Liu, H. and Chen, G. (2019) Immediate and Persistent Antidepressant-Like Effects of Chaihu-Jia-Longgu-Muli-Tang Are Associated with Instantly Up-Regulated BDNF in the Hippocampus of Mice. Bi-oscience Reports, 39, Article ID: BSR20181539. [Google Scholar] [CrossRef] 
[53] Jiao, Z., Zhao, H., Huang, W., Liang, R., Liu, Y., Li, Z., Li, L., Xu, Y., Gao, S., Gao, S., Li, Y. and Yu, C. (2021) An Investigation of the Antidepressant-Like Effect of Jiaotaiwan in Rats by Nontargeted Metabolomics Based on Ultra-High-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry. Journal of Separation Science, 44, 645-655. [Google Scholar] [CrossRef] [PubMed]
[54] Su, Z., Ruan, J., Liu, X., Zheng, H., Ruan, J., Lu, Y., Cheng, B., Wu, F., Wu, J., Liu, X., Song, F., Chen, Z., Song, H., Liang, Y. and Guo, H. (2021) Combining 1H-NMR-Based Metabonomics and Network Pharmacology to Dissect the Mecha-nism of Antidepression Effect of Milletia speciosa Champ on Mouse with Chronic Unpredictable Mild Stress-Induced Depression. Journal of Pharmacy and Pharmacology, 73, 881-892. [Google Scholar] [CrossRef] [PubMed]
[55] Li, R., Wang, Z.-M., Wang, Y., Dong, X., Zhang, L.-H., Wang, T., Zhu, Y., Gao, X.-M., Wu, H.-H. and Xu, Y.-T. (2021) An-tidepressant Activities and Regulative Effects on Serotonin Transporter of Nardostachys jatamansi DC. Journal of Eth-nopharmacology, 268, Article ID: 113601. [Google Scholar] [CrossRef] [PubMed]
[56] Wang, X.-L., Feng, S.-T., Wang, Y.-T., Chen, N.-H., Wang, Z.-Z. and Zhang, Y. (2021) Paeoniflorin: A Neuroprotective Monoterpenoid Glycoside with Promising Anti-Depressive Properties. Phytomedicine, 90, Article ID: 153669. [Google Scholar] [CrossRef] [PubMed]
[57] Lee, S. and Rhee, D.-K. (2017) Effects of Ginseng on Stress-Related Depression, Anxiety, and the Hypothalamic-Pituitary-Adrenal Axis. Journal of Ginseng Research, 41, 589-594. [Google Scholar] [CrossRef] [PubMed]
[58] Lu, J., Li, W., Gao, T., Wang, S., Fu, C. and Wang, S. (2022) The Association Study of Chemical Compositions and Their Pharmacological Effects of Cyperi Rhizoma (Xiangfu), a Potential Traditional Chinese Medicine for Treating Depression. Journal of Ethnopharmacology, 287, Arti-cle ID: 114962. [Google Scholar] [CrossRef] [PubMed]
[59] Ito, N., Sasaki, K., Hirose, E., Nagai, T., Isoda, H. and Odaguchi, H. (2022) Preventive Effect of a Kampo Medicine, Kososan, on Recurrent Depression in a Mouse Model of Repeated Social Defeat Stress. Gene, 806, Article ID: 145920. [Google Scholar] [CrossRef] [PubMed]
[60] Li, G.G., Lu, Y., He, P., Zhang, S.Y., Cheng, Y.T., Zhang, S.D., Pei, L. and Li, G. (2021) Target Prediction and Activity Verification for the Antidepressant Action of Huangqin (Radix Scutellariae Baicalensis). Journal of Traditional Chinese Medicine, 41, 845-852. [Google Scholar] [CrossRef] [PubMed]
[61] Lin, H.-Y., Tsai, J.-C., Wu, L.-Y. and Peng, W.-H. (2020) Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach. International Journal of Molecular Sciences, 21, Article No. 1868. [Google Scholar] [CrossRef] [PubMed]
[62] Fu, X., Jiao, J., Qin, T., Yu, J., Fu, Q., Deng, X., Ma, S. and Ma, Z. (2021) A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulat-ing PGC-1α. Neurotoxicity Research, 39, 872-885. [Google Scholar] [CrossRef] [PubMed]
[63] Shen, F., Song, Z., Xie, P., Li, L., Wang, B., Peng, D. and Zhu, G. (2021) Polygonatum sibiricum Polysaccharide Prevents De-pression-Like Behaviors by Reducing Oxidative Stress, Inflammation, and Cellular and Synaptic Damage. Journal of Ethnopharmacology, 275, Article ID: 114164. [Google Scholar] [CrossRef] [PubMed]
[64] Fu, C., Shuang, Q., Liu, Y., Zeng, L. and Su, W. (2022) Baihe Extracts Reduce the Activation and Apoptosis of Microglia in the Hippocam-pus of Mice with Depression-like Behaviors by Downregulating MYC. ACS Chemical Neuroscience, 13, 587-598. [Google Scholar] [CrossRef] [PubMed]
[65] Zhang, L., Previn, R., Lu, L., Liao, R.-F., Jin, Y. and Wang, R.-K. (2018) Crocin, a Natural Product Attenuates Lipopolysaccharide-Induced Anxiety and Depressive-Like Behaviors Through Suppressing NF-κB and NLRP3 Signaling Pathway. Brain Research Bulletin, 142, 352-359. [Google Scholar] [CrossRef] [PubMed]
[66] Wang, J.-M., Pei, L.-X., Zhang, Y.-Y., Cheng, Y.-X., Niu, C.-L., Cui, Y., Feng, W.-S. and Wang, G.-F. (2018) Ethanol Extract of Rehmannia glutinosa Exerts Antidepressant-Like Effects on a Rat Chronic Unpredictable Mild Stress Model by Involving Monoamines and BDNF. Metabolic Brain Dis-ease, 33, 885-892. [Google Scholar] [CrossRef] [PubMed]
[67] Qiao, Y.-L., Zhou, J.-J., Liang, J.-H., Deng, X.-P., Zhang, Z.-J., Huang, H.-L., Li, S., Dai, S.-F., Liu, C.-Q., Luan, Z.-L., Yu, Z.-L., Sun, C.-P. and Ma, X.-C. (2021) Uncaria rhyncho-phylla Ameliorates Unpredictable Chronic Mild Stress-Induced Depression in Mice via Activating 5-HT1A Receptor: In-sights from Transcriptomics. Phytomedicine, 81, Article ID: 153436. [Google Scholar] [CrossRef] [PubMed]
[68] Tan, L., Yang, Y., Peng, J., Zhang, Y., Wu, B., He, B., Jia, Y. and Yan, T. (2022) Schisandra chinensis (Turcz.) Baill. Essential Oil Exhibits Antidepressant-Like Effects and against Brain Oxidative Stress through Nrf2/HO-1 Pathway Activation. Metabolic Brain Disease, 37, 2261-2275. [Google Scholar] [CrossRef] [PubMed]
[69] Liu, T., Zhou, N., Xu, R., Cao, Y., Zhang, Y., Liu, Z., Zheng, X. and Feng, W. (2020) A Metabolomic Study on the Anti-Depressive Effects of Two Active Components from Chrysan-themum morifolium. Artificial Cells, Nanomedicine, and Biotechnology, 48, 718-727. [Google Scholar] [CrossRef] [PubMed]
[70] Zhang, B., Li, Y., Liu, M., Duan, X.-H., Hu, K.-L., Li, L.-N., Yu, X. and Chang, H.-S. (2020) Antidepressant-Like Mechanism of Honokiol in a Rodent Model of Corti-costerone-Induced Depression. Journal of Integrative Neuroscience, 19, 459-467. [Google Scholar] [CrossRef] [PubMed]
[71] Zhang, B., Wang, P.-P., Hu, K.-L., Li, L.-N., Yu, X., Lu, Y. and Chang, H.-S. (2019) Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccha-ride (LPS) Depression Model. Molecules, 24, Article No. 2035. [Google Scholar] [CrossRef] [PubMed]
[72] Cheng, J., Chen, M., Wan, H.-Q., Chen, X.-Q., Li, C.-F., Zhu, J.-X., Liu, Q., Xu, G.-H. and Yi, L.-T. (2021) Paeoniflorin Exerts Antidepressant-Like Effects through Enhancing Neu-ronal FGF-2 by Microglial Inactivation. Journal of Ethnopharmacology, 274, Article ID: 114046. [Google Scholar] [CrossRef] [PubMed]
[73] Ruan, J., Liu, L., Shan, X., Xia, B. and Fu, Q. (2019) An-ti-Depressant Effects of Oil from Fructus Gardeniae via PKA-CREB-BDNF Signaling. Bioscience Reports, 39, Article ID: BSR20190141. [Google Scholar] [CrossRef] 
[74] Chen, Y.-Y., Liu, Q.-P., An, P., Jia, M., Luan, X., Tang, J.-Y. and Zhang, H. (2022) Ginsenoside Rd: A Promising Natural Neuroprotective Agent. Phytomedicine, 95, Article ID: 153883. [Google Scholar] [CrossRef] [PubMed]
[75] Lou, T., Huang, Q., Su, H., Zhao, D. and Li, X. (2021) Tar-geting Sirtuin 1 Signaling Pathway by Ginsenosides. Journal of Ethnopharmacology, 268, Article ID: 113657. [Google Scholar] [CrossRef] [PubMed]
[76] Lou, Y.-X., Wang, Z.-Z., Xia, C.-Y., Mou, Z., Ren, Q., Liu, D.-D., Zhang, X. and Chen, N.-H. (2020) The Protective Effect of Ginsenoside Rg1 on Depression May Benefit from the Gap Junction Function in Hippocampal Astrocytes. European Journal of Pharmacology, 882, Article ID: 173309. [Google Scholar] [CrossRef] [PubMed]
[77] Cao, L.-H., Qiao, J.-Y., Huang, H.-Y., Fang, X.-Y., Zhang, R., Miao, M.-S. and Li, X.-M. (2019) PI3K-AKT Signaling Activation and Icariin: The Potential Effects on the Perimeno-pausal Depression-Like Rat Model. Molecules, 24, Article No. 3700. [Google Scholar] [CrossRef] [PubMed]
[78] Li, Z., Xu, H., Xu, Y., Lu, G., Peng, Q., Chen, J., Bi, R., Li, J., Chen, S., Li, H., Jin, H. and Hu, B. (2021) Morinda Officinalis Oligosaccharides Alleviate Depressive-Like Behaviors in Post-Stroke Rats via Suppressing NLRP3 Inflammasome to Inhibit Hippocampal Inflammation. CNS Neuroscience & Therapeutics, 27, 1570-1586. [Google Scholar] [CrossRef] [PubMed]
[79] Yang, S.-J., Song, Z.-J., Wang, X.-C., Zhang, Z.-R., Wu, S.-B. and Zhu, G.-Q. (2019) Curculigoside Facilitates Fear Extinction and Prevents Depression-Like Behaviors in a Mouse Learned Helplessness Model through Increasing Hippocampal BDNF. Acta Pharmacologica Sinica, 40, 1269-1278. [Google Scholar] [CrossRef] [PubMed]
[80] Dong, S.-Q., Zhang, Q.-P., Zhu, J.-X., Chen, M., Li, C.-F., Liu, Q., Geng, D. and Yi, L.-T. (2018) Gypenosides Reverses Depressive Behavior via Inhibiting Hippocampal Neuroin-flammation. Biomedicine & Pharmacotherapy, 106, 1153-1160. [Google Scholar] [CrossRef] [PubMed]
[81] Chen, X.-Q., Chen, S.-J., Liang, W.-N., Wang, M., Li, C.-F., Wang, S.-S., Dong, S.-Q., Yi, L.-T. and Li, C.-D. (2018) Saikosaponin A Attenuates Perimenopausal Depression-Like Symptoms by Chronic Unpredictable Mild Stress. Neuroscience Letters, 662, 283-289. [Google Scholar] [CrossRef] [PubMed]
[82] Zhang, R., Ma, Z., Liu, K., Li, Y., Liu, D., Xu, L., Deng, X., Qu, R., Ma, Z. and Ma, S. (2019) Baicalin Exerts Antidepressant Effects through Akt/FOXG1 Pathway Promoting Neuronal Differentiation and Survival. Life Sciences, 221, 241-248. [Google Scholar] [CrossRef] [PubMed]
[83] Zhang, C.-Y.-Y., Zeng, M.-J., Zhou, L.-P., Li, Y.-Q., Zhao, F., Shang, Z.-Y., Deng, X.-Y., Ma, Z.-Q., Fu, Q., Ma, S.-P. and Qu, R. (2018) Baicalin Exerts Neuroprotective Effects via Inhibiting Activation of GSK3β/NF-κB/NLRP3 Signal Path-way in a Rat Model of Depression. International Immunopharmacology, 64, 175-182. [Google Scholar] [CrossRef] [PubMed]
[84] Lu, Y., Sun, G., Yang, F., Guan, Z., Zhang, Z., Zhao, J., Liu, Y., Chu, L. and Pei, L. (2019) Baicalin Regulates Depression Behavior in Mice Exposed to Chronic Mild Stress via the Rac/LIMK/Cofilin Pathway. Biomedicine & Pharmacotherapy, 116, Article ID: 109054. [Google Scholar] [CrossRef] [PubMed]
[85] Chen, M., Zhang, Q.-P., Zhu, J.-X., Cheng, J., Liu, Q., Xu, G.-H., Li, C.-F. and Yi, L.-T. (2020) Involvement of FGF-2 Modulation in the Antidepressant-Like Effects of Liquiritin in Mice. European Journal of Pharmacology, 881, Article ID: 173297. [Google Scholar] [CrossRef] [PubMed]
[86] Ramaholimihaso, T., Bouazzaoui, F. and Kaladjian, A. (2020) Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review. Frontiers in Psychiatry, 11, Article ID: 572533. [Google Scholar] [CrossRef] [PubMed]
[87] Chen, Z., Gu, J., Lin, S., Xu, Z., Xu, H., Zhao, J., Feng, P., Tao, Y., Chen, S. and Wang, P. (2023) Saffron Essential Oil Ameliorates CUMS-Induced Depression-Like Behavior in Mice via the MAPK-CREB1-BDNF Signaling Pathway. Journal of Ethnopharmacology, 300, 115719. [Google Scholar] [CrossRef] [PubMed]
[88] Zhang, J.-H., Yang, H.-Z., Su, H., Song, J., Bai, Y., Deng, L., Feng, C.-P., Guo, H.-X., Wang, Y., Gao, X., Gu, Y., Zhen, Z. and Lu, Y. (2021) Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats. The American Journal of Chinese Medicine, 49, 1195-1213. [Google Scholar] [CrossRef] 
[89] Wang, Q.-S., Yan, K., Li, K.-D., Gao, L.-N., Wang, X., Liu, H., Zhang, Z., Li, K. and Cui, Y.-L. (2021) Targeting Hippocampal Phospholipid and Tryptophan Metabolism for Antide-pressant-Like Effects of Albiflorin. Phytomedicine, 92, Article ID: 153735. [Google Scholar] [CrossRef] [PubMed]
[90] Lin, J., Song, Z., Chen, X., Zhao, R., Chen, J., Chen, H., Yang, X. and Wu, Z. (2019) Trans-Cinnamaldehyde Shows Anti-Depression Effect in the Forced Swimming Test and Possible Involvement of the Endocannabinoid System. Biochemical and Biophysical Research Communications, 518, 351-356. [Google Scholar] [CrossRef] [PubMed]
[91] Liu, Z., Zou, Y., He, M., Yang, P., Qu, X. and Xu, L. (2022) Hy-droxysafflor Yellow A Can Improve Depressive Behavior by Inhibiting Hippocampal Inflammation and Oxidative Stress through Regulating HPA Axis. Journal of Biosciences, 47, Article No. 7. [Google Scholar] [CrossRef] [PubMed]
[92] Xu, L., Su, J., Guo, L., Wang, S., Deng, X. and Ma, S. (2019) Modulation of LPA1 Receptor-Mediated Neuronal Apoptosis by Saikosaponin-d: A Target Involved in Depression. Neuropharmacology, 155, 150-161. [Google Scholar] [CrossRef] [PubMed]
[93] Ye, T., Meng, X., Wang, R., Zhang, C., He, S., Sun, G. and Sun, X. (2018) Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice. International Journal of Molecular Sciences, 19, Article No. 3977. [Google Scholar] [CrossRef] [PubMed]
[94] Feng, R., He, M.-C., Li, Q., Liang, X.-Q., Tang, D.-Z., Zhang, J.-L., Liu, S.-F., Lin, F.-H. and Zhang, Y. (2020) Phenol Glycosides Extract of Fructus Ligustri Lucidi Attenuated Depres-sive-Like Behaviors by Suppressing Neuroinflammation in Hypothalamus of Mice. Phytotherapy Research, 34, 3273-3286. [Google Scholar] [CrossRef] [PubMed]
[95] He, M.-C., Shi, Z., Qin, M., Sha, N.-N., Li, Y., Liao, D.-F., Lin, F.-H., Shu, B., Sun, Y.-L., Yuan, T.-F., Wang, Y.-J. and Zhang, Y. (2020) Muscone Ameliorates LPS-Induced Depres-sive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice. The American Journal of Chinese Medicine, 48, 559-577. [Google Scholar] [CrossRef] 
[96] Wang, A.-R., Mi, L.-F., Zhang, Z.-L., Hu, M.-Z., Zhao, Z.-Y., Liu, B., Li, Y.-B. and Zheng, S. (2021) Saikosaponin A Improved Depression-Like Behavior and Inhibited Hippocampal Neuronal Apoptosis after Cerebral Ischemia through P-CREB/BDNF Pathway. Behavioural Brain Research, 403, Arti-cle ID: 113138. [Google Scholar] [CrossRef] [PubMed]
[97] Zhang, J., Yi, S., Li, Y., Xiao, C., Liu, C., Jiang, W., Yang, C. and Zhou, T. (2020) The Antidepressant Effects of Asperosaponin VI Are Mediated by the Suppression of Microglial Acti-vation and Reduction of TLR4/NF-κB-Induced IDO Expression. Psychopharmacology, 237, 2531-2545. [Google Scholar] [CrossRef] [PubMed]
[98] Zhang, L., Tang, M., Xie, X., Zhao, Q., Hu, N., He, H., Liu, G., Huang, S., Peng, C., Xiao, Y. and You, Z. (2021) Ginsenoside Rb1 Induces a Pro-Neurogenic Microglial Phenotype via PPARγ Activation in Male Mice Exposed to Chronic Mild Stress. Journal of Neuroinflammation, 18, Article No. 171. [Google Scholar] [CrossRef] [PubMed]
[99] Fan, L., Peng, Y., Wang, J., Ma, P., Zhao, L. and Li, X. (2021) Total Glycosides from Stems of Cistanche tubulosa Alleviate Depression-Like Behaviors: Bidirectional Interaction of the Phytochemicals and Gut Microbiota. Phytomedicine, 83, Article ID: 153471. [Google Scholar] [CrossRef] [PubMed]

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