沙库巴曲缬沙坦对于心衰的应用研究进展
Research Progress on the Application of Sacubitril/Valsartan to Heart Failure
DOI: 10.12677/ACM.2023.1351007, PDF,   
作者: 彭 鹏*, 朱军慧#:浙江大学医学院附属邵逸夫医院心内科,浙江 杭州
关键词: 心力衰竭沙库巴曲缬沙坦研究进展Research Progress on the Application of Sacubitril/Valsartan to Heart Failure
摘要: 心力衰竭,主要是指由于心脏功能或结构的异常,导致心室射血功能受损,无法满足正常组织代谢需要的临床综合征。根据其持续时间、产生速度、严重度又分为急性和慢性心衰。急性和慢性心衰均严重影响患者的正常工作和生活质量,复发率、伤残率、病死率居高不下,严重损害患者的身心健康。因此,寻求合适的药物治疗方案以满足心衰患者临床治疗需求,对改善患者的预后具有重要意义。沙库巴曲缬沙坦是一种脑啡肽酶/血管紧张素受体抑制剂(ARNI)。大量的临床试验结果显示,沙库巴曲缬沙坦可明显改善心衰患者心功能,并降低了相关不良反应发生率,为心衰病人的治疗提供了新的希望。现就沙库巴曲缬沙坦治疗心力衰竭的研究进展进行综述。
Abstract: Heart failure mainly refers to the clinical syndrome in which ventricular ejection function is im-paired due to abnormal heart function or structure, and cannot meet the needs of normal tissue metabolism. According to its duration, production rate, and severity, it is divided into acute and chronic heart failure. Both acute and chronic heart failure seriously affect the normal work and quality of life of patients, and the recurrence rate, disability rate and mortality rate remain high, which seriously damages the physical and mental health of patients. Therefore, it is of great signifi-cance to seek appropriate drug therapy regimens to meet the clinical treatment needs of patients with heart failure to improve the prognosis of patients. Sacubitril/valsartan is an enkepha-lin/angiotensin receptor inhibitor (ARNI). A large number of clinical trial results have shown that sacubitril-valsartan can significantly improve the heart function of patients with heart failure and reduce the incidence of related adverse reactions, providing new hope for the treatment of patients with heart failure. The research progress of sacubitril-valsartan in the treatment of heart failure is reviewed.
文章引用:彭鹏, 朱军慧. 沙库巴曲缬沙坦对于心衰的应用研究进展[J]. 临床医学进展, 2023, 13(5): 7203-7211. https://doi.org/10.12677/ACM.2023.1351007

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