儿童耐药癫痫的早期手术治疗研究进展
Advances in Early Surgical Treatment of Drug-Resistant Epilepsy in Children
DOI: 10.12677/ACM.2023.1351015, PDF,   
作者: 文世行:济宁医学院临床医学院,山东 济宁;张 璇*:济宁市第一人民医院神经内科,山东 济宁
关键词: 耐药癫痫儿童手术治疗Drug-Resistant Epilepsy Children Surgery Therapy
摘要: 癫痫是一种由多病因引起的脑部慢性疾病,以神经元过度放电导致反复性、发作性和短暂性的中枢神经系统功能失常为特征。多数患者在儿童期发病,并逐渐进展为耐药性癫痫,对患儿的智力造成极大的损伤,对患儿的生存能力造成了极大的危害,极大地降低了患儿的后期生活质量。对于耐药的儿童癫痫患者的外科治疗近些年技术发展迅速,疗效优于一般的药物治疗,但早期手术治疗的患者很少。本文主要就儿童耐药癫痫的早期手术治疗方式和效果方面来进行简要综述。
Abstract: Epilepsy is a chronic brain disease caused by multiple causes, characterized by recurrent, parox-ysmal and transient central nervous system dysfunction caused by excessive discharge of neurons. Most patients develop in childhood and gradually develop into drug-resistant epilepsy, which does great harm to the quality of life of the patients. The surgical treatment of drug-resistant children with epilepsy has developed rapidly in recent years, and the curative effect is better than that of general drug treatment, but the use is still not common enough, and there are few patients with early surgical treatment. This article mainly reviews the early surgical treatment of drug-resistant epilepsy in children.
文章引用:文世行, 张璇. 儿童耐药癫痫的早期手术治疗研究进展[J]. 临床医学进展, 2023, 13(5): 7257-7262. https://doi.org/10.12677/ACM.2023.1351015

参考文献

[1] Fisher, R.S., van Emde, B.W., Blume, W., et al. (2005) Epileptic Seizures and Epilepsy: Definitions Proposed by the In-ternational League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46, 470-472. [Google Scholar] [CrossRef] [PubMed]
[2] Aaberg, K.M., Gunnes, N., Bakken, I.J., et al. (2017) Inci-dence and Prevalence of Childhood Epilepsy: A Nationwide Cohort Study. Pediatrics, 139, e20163908. [Google Scholar] [CrossRef] [PubMed]
[3] Berg, A.T., Rychlik, K., Levy, S.R., et al. (2014) Complete Remission of Childhood-Onset Epilepsy: Stability and Prediction over Two Decades. Brain, 137, 3213-3222. [Google Scholar] [CrossRef] [PubMed]
[4] Danguecan, A.N. and Smith, M.L. (2017) Academic Outcomes in Indi-viduals with Childhood-Onset Epilepsy: Mediating Effects of Working Memory. Journal of the International Neuropsy-chological Society, 23, 594-604. [Google Scholar] [CrossRef
[5] Camfield, P. and Camfield, C. (2015) Incidence, Prevalence and Aetiology of Seizures and Epilepsy in Children. Epileptic Disorders, 17, 117-123. [Google Scholar] [CrossRef] [PubMed]
[6] Kwan, P., Arzimanoglou, A., Berg, A.T., et al. (2010) Definition of Drug Resistant Epilepsy: Consensus Proposal by the Ad Hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51, 1069-1077. [Google Scholar] [CrossRef] [PubMed]
[7] Kalilani, L., Sun, X., Pelgrims, B., et al. (2018) The Epi-demiology of Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis. Epilepsia, 59, 2179-2193. [Google Scholar] [CrossRef] [PubMed]
[8] Ravindra, V.M., Sweney, M.T. and Bollo, R.J. (2017) Recent Develop-ments in the Surgical Management of Paediatric Epilepsy. Archives of Disease in Childhood, 102, 760-766. [Google Scholar] [CrossRef] [PubMed]
[9] Bello-Espinosa, L.E. and Olavarria, G. (2021) Epilepsy Surgery in Children. Pediatric Clinics of North America, 68, 845-856. [Google Scholar] [CrossRef] [PubMed]
[10] Loscher, W., Potschka, H., Sisodiya, S.M., et al. (2020) Drug Re-sistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options. Pharmacological Reviews, 72, 606-638. [Google Scholar] [CrossRef] [PubMed]
[11] Fang, M., Xi, Z.Q., Wu, Y., et al. (2011) A New Hypothesis of Drug Refractory Epilepsy: Neural Network Hypothesis. Medical Hypotheses, 76, 871-876. [Google Scholar] [CrossRef] [PubMed]
[12] Schmidt, D. and Loscher, W. (2005) Drug Resistance in Epilepsy: Putative Neurobiologic and Clinical Mechanisms. Epilepsia, 46, 858-877. [Google Scholar] [CrossRef] [PubMed]
[13] Tate, S.K., Depondt, C., Sisodiya, S.M., et al. (2005) Ge-netic Predictors of the Maximum Doses Patients Receive during Clinical Use of the Anti-Epileptic Drugs Carbamazepine and Phenytoin. Proceedings of the National Academy of Sciences of the United States of America, 102, 5507-5512. [Google Scholar] [CrossRef] [PubMed]
[14] Kobow, K., El-Osta, A. and Blumcke, I. (2013) The Methylation Hypothesis of Pharmacoresistance in Epilepsy. Epilepsia, 54, 41-47. [Google Scholar] [CrossRef] [PubMed]
[15] Engel, J.J. (2019) Evolution of Concepts in Epilepsy Surgery. Epileptic Disorders, 21, 391-409.
[16] Guerrini, R., Scerrati, M., Rubboli, G., et al. (2013) Overview of Presurgical Assessment and Surgical Treatment of Epilepsy from the Italian League against Epilepsy. Epilepsia, 54, 35-48. [Google Scholar] [CrossRef] [PubMed]
[17] Consales, A., Casciato, S., Asioli, S., et al. (2021) The Surgical Treatment of Epilepsy. Neurological Sciences, 42, 2249-2260. [Google Scholar] [CrossRef] [PubMed]
[18] Giulioni, M., Marucci, G., Pelliccia, V., et al. (2017) Epilepsy Surgery of “Low Grade Epilepsy Associated Neuroepithelial Tumors”: A Retrospective Nationwide Italian Study. Epi-lepsia, 58, 1832-1841. [Google Scholar] [CrossRef] [PubMed]
[19] Hu, W.H., Zhang, C., Zhang, K., et al. (2013) Selective Amygdalohippo-campectomy versus Anterior Temporal Lobectomy in the Management of Mesial Temporal Lobe Epilepsy: A Me-ta-Analysis of Comparative Studies. Journal of Neurosurgery, 119, 1089-1097. [Google Scholar] [CrossRef
[20] Ryvlin, P., Cross, J.H. and Rheims, S. (2014) Epilepsy Surgery in Children and Adults. The Lancet Neurology, 13, 1114-1126. [Google Scholar] [CrossRef
[21] Barba, C., Cossu, M., Guerrini, R., et al. (2021) Temporal Lobe Epilepsy Surgery in Children and Adults: A Multicenter Study. Epilepsia, 62, 128-142. [Google Scholar] [CrossRef] [PubMed]
[22] Sood, S., Marupudi, N.I., Asano, E., et al. (2015) Endoscopic Corpus Cal-losotomy and Hemispherotomy. Journal of Neurosurgery: Pediatrics, 16, 681-686. [Google Scholar] [CrossRef
[23] Villemure, J.G., Vernet, O. and Delalande, O. (2000) Hemispheric Disconnection: Callosotomy and Hemispherotomy. Advances and Technical Standards in Neurosurgery, 26, 25-78. [Google Scholar] [CrossRef] [PubMed]
[24] 秦广彪, 张培胜, 马康平, 等. 大脑半球切开术治疗儿童顽固性癫痫[J]. 临床神经外科杂志, 2016, 13(4): 285-288.
[25] Matern, T.S., DeCarlo, R., Ciliberto, M.A., et al. (2021) Palliative Epilepsy Surgery Procedures in Children. Seminars in Pediatric Neurology, 39, Article ID: 100912. [Google Scholar] [CrossRef] [PubMed]
[26] Fisher, R.S. and Velasco, A.L. (2014) Electrical Brain Stimulation for Epilepsy. Nature Reviews Neurology, 10, 261-270. [Google Scholar] [CrossRef] [PubMed]
[27] Sobstyl, M., Stapinska-Syniec, A., Iwanski, S., et al. (2021) Clinical Efficacy and Safety Profile of Anterior Thalamic Stimulation for Intractable Epilepsy. Journal of Neurological Surgery, Part A: Central European Neurosurgery, 82, 568-580. [Google Scholar] [CrossRef] [PubMed]
[28] Guglielmi, G., Eschbach, K.L. and Alexander, A.L. (2021) Smaller Knife, Fewer Seizures? Recent Advances in Minimally Invasive Techniques in Pediatric Epilepsy Surgery. Seminars in Pediatric Neurology, 39, Article ID: 100913. [Google Scholar] [CrossRef] [PubMed]
[29] Martinez-Fernandez, R., Manez-Miro, J.U., Rodriguez-Rojas, R., et al. (2020) Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease. The New England Journal of Medicine, 383, 2501-2513. [Google Scholar] [CrossRef
[30] Halpern, C.H., Santini, V., Lipsman, N., et al. (2019) Three-Year Follow-Up of Prospective Trial of Focused Ultrasound Thalamotomy for Essential Tremor. Neurology, 93, e2284-e2293. [Google Scholar] [CrossRef
[31] Davidson, B., Hamani, C., Rabin, J.S., et al. (2020) Mag-netic Resonance-Guided Focused Ultrasound Capsulotomy for Refractory Obsessive Compulsive Disorder and Major Depressive Disorder: Clinical and Imaging Results from Two Phase I Trials. Molecular Psychiatry, 25, 1946-1957. [Google Scholar] [CrossRef] [PubMed]
[32] Giammalva, G.R., Gagliardo, C., Marrone, S., et al. (2021) Fo-cused Ultrasound in Neuroscience. State of the Art and Future Perspectives. Brain Sciences, 11, 84. [Google Scholar] [CrossRef] [PubMed]
[33] Hooten, K.G., Werner, K., Mikati, M.A., et al. (2018) MRI-Guided Laser Interstitial Thermal Therapy in an Infant with Tuberous Sclerosis: Technical Case Report. Journal of Neurosurgery: Pediatrics, 23, 92-97. [Google Scholar] [CrossRef
[34] Kuo, C.H., Feroze, A.H., Poliachik, S.L., et al. (2019) Laser Abla-tion Therapy for Pediatric Patients with Intracranial Lesions in Eloquent Areas. World Neurosurgery, 121, e191-e199. [Google Scholar] [CrossRef] [PubMed]
[35] Markert, M.S. and Fisher, R.S. (2019) Neuromodula-tion—Science and Practice in Epilepsy: Vagus Nerve Stimulation, Thalamic Deep Brain Stimulation, and Responsive NeuroStimulation. Expert Review of Neurotherapeutics, 19, 17-29. [Google Scholar] [CrossRef] [PubMed]
[36] Tsai, J., Fan, P., Lee, W., et al. (2021) Vagus Nerve Stimu-lation in Pediatric Patients with Failed Epilepsy Surgery. Acta Neurologica Belgica, 121, 1305-1309. [Google Scholar] [CrossRef] [PubMed]
[37] Wang, D., Wei, P., Shan, Y., et al. (2020) Optimized Stereoelec-troencephalography-Guided Radiofrequency Thermocoagulation in the Treatment of Patients with Focal Epilepsy. Annals of Translational Medicine, 8, 15. [Google Scholar] [CrossRef] [PubMed]
[38] Catenoix, H., Bourdillon, P., Guenot, M., et al. (2018) The Combi-nation of Stereo-EEG and Radiofrequency Ablation. Epilepsy Research, 142, 117-120. [Google Scholar] [CrossRef] [PubMed]
[39] Rennert, R.C., Tringale, K., Steinberg, J.A., et al. (2020) Surgical Management of Spontaneous Intracerebral Hemorrhage: Insights from Randomized Controlled Trials. Neuro-surgical Review, 43, 999-1006. [Google Scholar] [CrossRef] [PubMed]
[40] Abel, T.J., Losito, E., Ibrahim, G.M., et al. (2018) Multimodal Localization and Surgery for Epileptic Spasms of Focal Origin: A Review. Neurosurgical Focus, 45, E4. [Google Scholar] [CrossRef
[41] Centeno, R.S., Yacubian, E.M., Sakamoto, A.C., et al. (2006) Pre-Surgical Evaluation and Surgical Treatment in Children with Extratemporal Epilepsy. Child’s Nervous System, 22, 945-959. [Google Scholar] [CrossRef] [PubMed]
[42] Ueda, R., Kaga, Y., Kita, Y., et al. (2021) Postoperative Im-provement of Executive Function and Adaptive Behavior in Children with Intractable Epilepsy. Brain and Development, 43, 280-287. [Google Scholar] [CrossRef] [PubMed]
[43] Asranna, A., Babu Pasangulapati, S., Menon, R., et al. (2021) Trends in Pediatric Epilepsy Surgery: A Lower-Middle-Income Country Perspective. Acta Neurologica Scandinavica, 143, 521-529. [Google Scholar] [CrossRef] [PubMed]