冠心病患者静息态脑网络改变

Changes of Resting-State Brain Network in Patients with Coronary Heart Disease

摘要: 目的：利用静息态功能磁共振成像结合图论分析方法探究冠心病患者脑网络拓扑属性变化。方法：纳入我院50例冠心病患者与50例性别、年龄、受教育年限相匹配的健康对照者，分别进行静息态功能磁共振扫描，图像预处理后计算相关系数构建功能连接网络，并用图论方法分析其拓扑属性(包括小世界属性、局部效率、全局效率)。某一脑区介数中心性超过平均节点中心性2个标准差，则被认为是核心节点。采用双样本T检验比较两组之间的网络拓扑属性差异。结果：冠心病组与对照组在局部效率、全局效率和小世界属性方面差异并不显著(P > 0.05)。冠心病组核心节点主要有：右侧补充运动区和双侧楔前叶。然而，对照组核心节点包括：右侧额上回，右侧补充运动区，左侧楔前叶和左侧颞中回。结论：冠心病组脑网络拓扑属性已发生明显改变，提示静息态功能磁共振为探究心脑轴提供新角度。

Abstract: Objective: It is unclear that how the brain functional network of coronary heart disease (CHD) pa-tients changes. To explore the alternation of brain network attributes in patients with CHD by rest-ing-state functional magnetic resonance imaging. Material: 3T-resting-state functional magnetic resonance scanning was performed on 50 patients with CHD and 50 healthy controls (HCs) matched by gender, age and years of education from our hospital, the correlation coefficient was calculated after image preprocessing to construct a functional connection network, and the topological proper-ties (small-worldness, local efficiency, global efficiency) were analyzed by graph theory. A node was set a hub if its betweenness centrality was more than two standard deviations comparing with the mean nodal centrality. Two-sample t-test was used to compare the differences in network topologies between the two groups. Results: No significant difference can be seen in terms of local efficiency, global efficiency, and small-world between the CHD and HCs (P > 0.05). The hub nodes of the pa-tients with CHD were right supplementary motor area and bilateral precuneus, whereas those for the HCs were right superior frontal gyrus, right supplementary motor area, left precuneus and mid-dle temporal gyrus. Conclusion: The topological properties of the brain network CHD patients have changed significantly, and resting functional magnetic resonance provides a new insight for explor-ing the cardio-brain axis.