细菌性阴道病和阴道菌群的最新研究进展
The Latest Research Progress of Bacterial Vaginal Disease and Vaginal Flora
DOI: 10.12677/ACM.2023.1351066, PDF,    科研立项经费支持
作者: 王 雨*, 李志英#:三峡大学附属仁和医院妇产科,湖北 宜昌;周永芹:三峡大学感染与炎症损伤研究所,湖北 宜昌
关键词: 阴道微环境细菌性阴道病乳酸杆菌Vaginal Microenvironment Bacterial Vaginal Disease Lactic Acid Bacteria
摘要: 阴道微生物群是一个复杂而动态的微生态系统,在女性月经周期和整个生命周期中不断发生波动。一个健康的阴道微生物群主要由乳酸杆菌组成,它能产生各种抗菌化合物。细菌性阴道病(Bacterial Vaginosis, BV)是一种阴道微生物菌群失调所致的一种阴道炎性疾病,是全球育龄妇女中高度流行的下生殖道疾病,BV的发生受多种因素影响。本文通过细菌性阴道病状态下阴道微生物群的不同变化及其影响因素的相关研究,综合性叙述了细菌性阴道病和阴道菌群的相关性。
Abstract: The vaginal microbiota is a complex and dynamic micro-ecosystem that continuously fluctuates during the female menstrual cycle and throughout the life cycle. A healthy vaginal microbiome con-sists primarily of Lactobacillus, which produces a variety of antimicrobial compounds. Bacterial vaginosis (BV) is a vaginal inflammatory disease caused by the imbalance of vaginal microbial flora. It is a highly prevalent lower genital tract disease among women of childbearing age worldwide. This article comprehensively describes the correlation between bacterial vaginosis and vaginal flo-ra through the study of the different changes of vaginal microbiota and its influencing factors in the state of bacterial vaginosis.
文章引用:王雨, 李志英, 周永芹. 细菌性阴道病和阴道菌群的最新研究进展[J]. 临床医学进展, 2023, 13(5): 7630-7636. https://doi.org/10.12677/ACM.2023.1351066

参考文献

[1] Javed, A., Parvaiz, F. and Manzoor, S. (2019) Bacterial Vaginosis: An Insight into the Prevalence, Alternative Treat-ments Regimen and It’s Associated Resistance Patterns. Microbial Pathogenesis, 127, 21-30. [Google Scholar] [CrossRef] [PubMed]
[2] Peebles, K., et al. (2019) High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis. Sexually Transmitted Diseases, 46, 304-311. [Google Scholar] [CrossRef
[3] 杨海燕. 育龄妇女细菌性阴道病的流行病调查分析[J]. 世界最新医学信息文摘, 2017, 17(13): 52.
[4] Saraf, V.S., et al. (2021) Vaginal Microbiome: Normalcy vs Dysbiosis. Archives of Microbiology, 203, 3793-3802. [Google Scholar] [CrossRef] [PubMed]
[5] Mulu, W., Yimer, M., Zenebe, Y. and Abera, B. (2015) Com-mon Causes of Vaginal Infections and Antibiotic Susceptibility of Aerobic Bacterial Isolates in Women of Reproductive Age Attending at Felegehiwot Referral Hospital, Ethiopia: A Cross Sectional Study. BMC Women’s Health, 15, Article No. 42. [Google Scholar] [CrossRef] [PubMed]
[6] Chen, C., et al. (2017) The Microbiota Continuum along the Fe-male Reproductive Tract and Its Relation to Uterine-Related Diseases. Nature Communications, 8, Article No. 875. [Google Scholar] [CrossRef] [PubMed]
[7] Ravel, J., et al. (2011) Vaginal Microbiome of Reproductive-Age Women. Proceedings of the National Academy of Sciences of the United States of America, 108, 4680-4687. [Google Scholar] [CrossRef] [PubMed]
[8] Jiang, L., et al. (2019) The Role of the miR1976/CD105/Integrin Alphavbeta6 Axis in Vaginitis Induced by Escherichia coli Infection in Mice. Scientific Reports, 9, Article No. 14456. [Google Scholar] [CrossRef] [PubMed]
[9] Smith, S.B. and Ravel, J. (2017) The Vaginal Microbiota, Host Defence and Reproductive Physiology. The Journal of Physiology, 595, 451-463. [Google Scholar] [CrossRef
[10] Mitra, A., et al. (2016) The Vaginal Microbiota, Human Papillomavirus In-fection and Cervical Intraepithelial Neoplasia: What Do We Know and Where Are We Going Next? Microbiome, 4, Arti-cle No. 58. [Google Scholar] [CrossRef] [PubMed]
[11] Chen, X., Lu, Y., Chen, T. and Li, R.G. (2021) The Female Vag-inal Microbiome in Health and Bacterial Vaginosis. Frontiers in Cellular and Infection Microbiology, 11, Article ID: 631972. [Google Scholar] [CrossRef] [PubMed]
[12] Coudray, M.S. and Madhivanan, P. (2020) Bacterial Vaginosis—A Brief Synopsis of the Literature. The European Journal of Obstetrics & Gynecology and Reproductive Bi-ology, 245, 143-148. [Google Scholar] [CrossRef] [PubMed]
[13] Kenyon, C., Colebunders, R. and Crucitti, T. (2013) The Global Epidemiology of Bacterial Vaginosis: A Systematic Review. American Journal of Obstetrics & Gynecology, 209, 505-523. [Google Scholar] [CrossRef] [PubMed]
[14] Huang, B., et al. (2014) The Changing Landscape of the Vaginal Microbiome. Clinics in Laboratory Medicine, 34, 747-761. [Google Scholar] [CrossRef] [PubMed]
[15] 冯彩红, 等. 细菌性阴道病合并人乳头瘤病毒感染的影响因素[J]. 中国微生态学杂志, 2019, 31(5): 560-563.
[16] Reid, G. (2018) Is Bacterial Vaginosis a Disease? Applied Microbiology and Biotechnology, 102, 553-558. [Google Scholar] [CrossRef] [PubMed]
[17] Francis, S.C., et al. (2020) The Vaginal Microbiota among Ado-lescent Girls in Tanzania around the Time of Sexual Debut. Frontiers in Cellular and Infection Microbiology, 10, Article No. 305. [Google Scholar] [CrossRef] [PubMed]
[18] Francis, S.C., et al. (2019) Results from a Cross-Sectional Sexual and Reproductive Health Study among School Girls in Tanzania: High Prevalence of Bacterial Vaginosis. Sexually Transmitted Infections, 95, 219-227. [Google Scholar] [CrossRef] [PubMed]
[19] Vodstrcil, L.A., et al. (2019) Combined Oral Contraceptive Pill-Exposure Alone Does Not Reduce the Risk of Bacterial Vaginosis Recurrence in a Pilot Randomised Controlled Trial. Scientific Reports, 9, Article No. 3555. [Google Scholar] [CrossRef] [PubMed]
[20] Ratten, L.K., et al. (2021) Sex Is Associated with the Persistence of Non-Optimal Vaginal Microbiota Following Treatment for Bacterial Vaginosis: A Prospective Cohort Study. BJOG, 128, 756-767. [Google Scholar] [CrossRef] [PubMed]
[21] Brotman, R.M., et al. (2014) Association between Cigarette Smok-ing and the Vaginal Microbiota: A Pilot Study. BMC Infectious Diseases, 14, Article No. 471. [Google Scholar] [CrossRef] [PubMed]
[22] Nelson, T.M., et al. (2018) Cigarette Smoking Is Associated with an Altered Vaginal Tract Metabolomic Profile. Scientific Reports, 8, Article No. 852. [Google Scholar] [CrossRef] [PubMed]
[23] Zhu, D., et al. (2018) Relationships between Intensity, Duration, Cumulative Dose, and Timing of Smoking with Age at Menopause: A Pooled Analysis of Individual Data from 17 Ob-servational Studies. PLoS Medicine, 15, e1002704. [Google Scholar] [CrossRef] [PubMed]
[24] Amsel, R., et al. (1983) Nonspecific Vaginitis. Diagnostic Cri-teria and Microbial and Epidemiologic Associations. The American Journal of Medicine, 74, 14-22. [Google Scholar] [CrossRef] [PubMed]
[25] Nugent, R.P., Krohn, M.A. and Hillier, S.L. (1991) Reliability of Diagnosing Bacterial Vaginosis Is Improved by a Standardized Method of Gram Stain Interpretation. Journal of Clin-ical Microbiology, 29, 297-301. [Google Scholar] [CrossRef] [PubMed]
[26] Nasioudis, D., Linhares, I.M., Ledger, W.J. and Witkin, S.S. (2017) Bacterial Vaginosis: A Critical Analysis of Current Knowledge. BJOG, 124, 61-69. [Google Scholar] [CrossRef] [PubMed]
[27] 李婷, 刘朝晖. 2020年美国妇产科医师学会《非妊娠期阴道炎》管理指南解读[J]. 中国实用妇科与产科杂志, 2021, 37(2): 205-207.
[28] Breding, K., et al. (2020) Diagnosis of Bacterial Vaginosis Using a Novel Molecular Real-Time PCR Test. Journal of Women’s Health and Gynecology, 7, Ar-ticle No. 102.
[29] Coleman, J.S. and Gaydos, C.A. (2018) Molecular Diagnosis of Bacterial Vaginosis: An Update. Journal of Clinical Microbiology, 43, 1304-1308. [Google Scholar] [CrossRef
[30] van der Veer, C., van Houdt, R., van Dam, A., de Vries, H. and Bruisten, S. (2018) Accuracy of a Commercial Multiplex PCR for the Di-agnosis of Bacterial Vaginosis. Journal of Medical Microbiology, 67, 1265-1270. [Google Scholar] [CrossRef] [PubMed]
[31] Paavonen, J.A. and Brunham, R.C. (2020) Vaginitis in Nonpregnant Patients: ACOG Practice Bulletin Number 215. Obstetrics & Gynecology, 135, 1229-1230. [Google Scholar] [CrossRef
[32] Armstrong, E., et al. (2022) Metronidazole Treatment Rap-idly Reduces Genital Inflammation through Effects on Bacterial Vaginosis-Associated Bacteria Rather than Lactobacilli. Journal of Clinical Investigation, 132, e152930. [Google Scholar] [CrossRef
[33] Sobel, J.D., et al. (2019) Prognostic Indicators of Recurrence of Bacterial Vaginosis. Journal of Clinical Microbiology, 57, e00227-19. [Google Scholar] [CrossRef
[34] 段红波, 等. 中药治疗阴道病研究进展[J]. 中国实验方剂学杂志, 2017, 23(19): 227-234.
[35] Wang, X.Q., et al. (2020) Rheology and in Vitro Release Properties of Thermosensitive in Situ Gel of Yihuang Decoction and Its Common Gel for Vaginal Use. China Journal of Chinese Materia Medica, 45, 539-547.
[36] Zhao, H., Zhao, L.J., Wu, F. and Shen, L. (2021) Clinical Research on Traditional Chinese Medicine Treatment for Bacterial Vaginosis. Phytotherapy Research, 35, 4943-4956. [Google Scholar] [CrossRef] [PubMed]
[37] Izzo, A.A., Hoon-Kim, S., Radhakrishnan, R. and Williamson, E.M. (2016) A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Reme-dies. Phytotherapy Research, 30, 691-700. [Google Scholar] [CrossRef] [PubMed]
[38] Jeng, H.S., Yan, T.R. and Chen, J.Y. (2020) Treating Vaginitis with Probiot-ics in Non-Pregnant Females: A Systematic Review and Meta-Analysis. Experimental and Therapeutic Medicine, 20, 3749-3765. [Google Scholar] [CrossRef] [PubMed]
[39] Pino, A., et al. (2021) A Clinical Pilot Study on the Effect of the Probi-otic Lacticaseibacillus rhamnosus TOM 22.8 Strain in Women with Vaginal Dysbiosis. Scientific Reports, 11, Article No. 2592. [Google Scholar] [CrossRef] [PubMed]
[40] Chen, T., et al. (2021) Dysbiosis of the Rat Vagina Is Efficiently Rescued by Vaginal Microbiota Transplantation or Probiotic Combination. International Journal of Antimicrobial Agents, 57, Article ID: 106277. [Google Scholar] [CrossRef] [PubMed]