高脂饮食与抑郁症的相关性及机制研究进展
Research Progress in the Correlation and Mechanism between High-Fat Diet and Depression
DOI: 10.12677/ACM.2023.1351083, PDF,  被引量    国家自然科学基金支持
作者: 李晓娜*, 张梦婷, 王玉婕, 赵彦鑫：黑龙江中医药大学研究生学院，黑龙江 哈尔滨；任 蓁#：黑龙江中医药大学附属第一医院护理部，黑龙江 哈尔滨
关键词: 高脂饮食；抑郁症；色氨酸；氧化应激；High-Fat Diet； Depression； Tryptophan； Oxidative Stress
摘要: 抑郁症是严重精神疾病之一，因其患病率高、复发率高以及自杀致残率高的特点给社会带来极大负担。如今快节奏生活导致人们承受更大的心理压力，更有甚者会导致抑郁症、焦虑症以及躁郁症等精神疾病的发生。已有确凿证据，饮食习惯与抑郁的关系紧密相关，不当饮食是抑郁症的危险因素，健康饮食对抑郁症具有积极正面的影响。同时，抑郁症患者常出现营养问题，如肥胖和代谢综合征等。随着人们生活水平的提高，饮食多元化的发展，高脂饮食在饮食结构中所占比例越来越大，而高脂饮食可导致动物出现焦虑抑郁的情绪已得到广泛证实，但高脂饮食对抑郁症的影响机制尚不明确。本文基于过往文献资料综述梳理了高脂饮食与抑郁症之间的关联性，及高脂饮食诱导抑郁症的发病机制。
Abstract: Depression is one of the serious mental illnesses, which brings a great burden to the society because of its high prevalence, high relapse rate and high disability rate of suicide. Today’s fast- paced life leads to greater psychological stress, which can even lead to depression, anxiety and bipolar disor-der. It has been conclusively proven that dietary habits are closely related to depression, that im-proper diet is a risk factor for depression, and that a healthy diet has a positive impact on depres-sion. Also, depressed patients often have nutritional problems, such as obesity and metabolic syn-drome. With the improvement of people’s living standards and the development of diversified diets, high-fat diets are taking up an increasing proportion of the dietary structure, and it has been widely confirmed that high-fat diets can lead to anxiety and depression in animals, but the mechanism of the effect of high-fat diets on depression is unclear. This paper compares the association between high-fat diet and depression and the pathogenesis of high-fat diet-induced depression based on a review of previous literature.
文章引用：李晓娜, 张梦婷, 王玉婕, 赵彦鑫, 任蓁. 高脂饮食与抑郁症的相关性及机制研究进展[J]. 临床医学进展, 2023, 13(5): 7754-7760. https://doi.org/10.12677/ACM.2023.1351083

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