绝经前2型糖尿病患者的维生素D状况研究

Vitamin D Status Study in Premenopausal Type 2 Diabetic Patients

摘要: 目的：分析和探讨住院绝经前2型糖尿病患者中血清25羟维生素D的水平并分析其与糖代谢指标之间的相关性。方法：本研究为回顾性分析，收集2019年1月~2021年8月在西安市中心医院内分泌科住院的65例绝经前2型糖尿病患者的临床资料，选取同时间段健康体检中心445例作为对照，根据25羟维生素D的水平分为维生素D缺乏(<20 ng/mL)、不足(≥20 ng/mL)两组。测定糖代谢指标包括糖化血红蛋白、空腹血糖。结果：绝经前2型糖尿病患者与健康体检人群两组间比较差异有统计学意义(P < 0.05)。绝经前2型糖尿病患者中25羟维生素D缺乏组、不足组分别占的比例为81.5%、18.5%。糖代谢指标在两组间差异无统计学意义。Pearson及Spearman相关性分析提示25羟维生素D与空腹血糖、糖化血红蛋白、BMI、年龄及初潮年龄均无相关性。结论：绝经前2型糖尿病患者普遍存在维生素D非充足状态，与健康人群相比其更加缺乏维生素D。绝经前2型糖尿病患者25羟维生素D与空腹血糖、糖化血红蛋白、BMI、年龄及初潮年龄水平无关。

Abstract: Objective: To analyze and investigate the serum 25 hydroxyvitamin D levels in hospitalized premenopausal type 2 diabetic patients and analyze the correlation between them and glucose metabolism indexes. Methods: This study was a retrospective analysis, and the clinical data of 65 premenopausal type 2 diabetic patients hospitalized in the Department of Endocrinology of Xi’an Central Hospital from January 2019 to August 2021 were collected, and 445 cases from the health check-up center in the same time period were selected as controls and divided into two groups ac-cording to the level of 25 hydroxyvitamin D as vitamin D deficiency (<20 ng/mL) and deficiency (≥20 ng/mL). Glucose metabolism indexes including glycated hemoglobin and fasting glucose were measured. Results: There was a statistically significant difference between the two groups of premenopausal type 2 diabetic patients and healthy physical examination population (P < 0.05). The proportion of premenopausal type 2 diabetic patients in the 25-hydroxyvitamin D deficiency group and the deficiency group were 81.5% and 18.5%, respectively. Pearson and Spearman corre-lation analyses showed no correlation between 25 hydroxyvitamin D and fasting glucose, glycated hemoglobin, BMI, age and age at menarche. Conclusion: Premenopausal patients with type 2 diabe-tes are generally non-sufficient in vitamin D and are more deficient in vitamin D than the healthy population. 25 hydroxyvitamin D in premenopausal patients with type 2 diabetes is not associated with fasting glucose, glycosylated hemoglobin, BMI, age and age at menarche.