肠上皮细胞的微生物调节与炎症性肠病

Microbial Regulation of Intestinal Epithelial Cells and Inflammatory Bowel Disease

摘要: 小肠是机体消化和吸收的重要场所，通过肠上皮细胞(IEC)吸收营养物质，肠上皮细胞(IEC)是肠道内外环境的媒介，也是机体免疫屏障的重要组成部分，它的存在使肠道内部处于一种稳态。炎症性肠病(inflammatory bowel disease, IBD)是一种慢性非特异性肠道炎症，由于IBD的病因尚未阐述清楚，发病机制复杂多样，使其传统治疗效果有限、副作用较多、且难以根治，使病人的生活质量下降，给患者和其家属及社会带来了巨大的负担，如今主流观点认为由于肠道微环境和免疫失衡有关，本综述旨在概述肠上皮细胞的微生物调节在IBD中发挥的作用。

Abstract: The small intestine is an important site of digestion and absorption for the body, receiving nutrients through the intestinal epithelium (IEC), which mediates the internal and external environment of the intestine and is an important component of the immune barrier of the body, and its presence keeps the interior of the intestine in a homeostatic state. Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the intestinal tract. Because the etiology of IBD has not been clearly elucidated and the pathogenesis is complex and diverse, the effectiveness of traditional treatment is limited, with many side effects, and it is difficult to be cured, which decreases the qual-ity of life of patients and brings a great burden to patients, their families and the society. The pre-vailing view is that it is related to the intestinal microenvironment and immune imbalance, and this review aims to provide an overview of the role played by microbial regulation of the intestinal epi-thelium in IBD.