MicroRNA表达与糖尿病肾病临床意义的研究进展
Research Progress on MicroRNA Expression and Clinical Significance of Diabetic Nephropathy
DOI: 10.12677/ACM.2023.1351109, PDF,    科研立项经费支持
作者: 李彤彤：西安医学院研究生院，陕西 西安；西安医学院第一附属医院内分泌科，陕西 西安 ；李 亚*：西安医学院第一附属医院内分泌科，陕西 西安
关键词: MicroRNA；糖尿病肾病；作用机制；MicroRNA； Diabetic Nephropathy； Pathogenesis
摘要: 糖尿病肾病(Diabetic Nephropathy, DN)是引起终末期肾病的最主要原因之一，但其发病机制尚未完全明确，且患者预后欠佳。MicroRNAs是近年来新发现的有重要的临床意义的非编码单链RNA分子，许多MicroRNA被证实在DN患者中表达异常且与其发病机制相关。本文综述探讨了MicroRNA表达在糖尿病肾病中的作用机制，为糖尿病肾病的治疗提供参考。
Abstract: Diabetic nephropathy (DN) is one of the most leading causes of end-stage renal disease, but its pathogenesis is not fully defined, and the prognosis of clinical patients is poor. MicroRNAs are newly identified non-coding single-stranded RNA molecules of great clinical significance in recent years, and many MicroRNAs were confirmed to be aberrantly expressed in DN patients and associated with their pathogenesis. In this paper, the mechanism of MicroRNA expression in diabetic nephropathy is reviewed, which provides a reference for the treatment of diabetic nephropathy.
文章引用：李彤彤, 李亚. MicroRNA表达与糖尿病肾病临床意义的研究进展[J]. 临床医学进展, 2023, 13(5): 7928-7933. https://doi.org/10.12677/ACM.2023.1351109

参考文献

[1] Xue, R., Gui, D., Zheng, L., et al. (2017) Mechanistic Insight and Management of Diabetic Nephropathy: Recent Pro-gress and Future Perspective. Journal of Diabetes Research, 2017, Article ID: 1839809. [Google Scholar] [CrossRef] [PubMed]
[2] 柯昌荣, 赵树勇, 玄美燕, 等. 中国1990-2019年慢性肾病疾病负担及变化趋势分析[J]. 中国预防医学杂志, 2021, 22(10): 757-761.
[3] 熊思, 彭辉勇, 柳迎昭. MicroRNAs在糖尿病肾病中的研究进展[J]. 中国现代医学杂志, 2019, 29(1): 60-66.
[4] 田莎莎, 杨晓鹏, 郭珲. 微小RNA在糖尿病肾病中的研究进展[J]. 中国医药导报, 2020, 17(27): 58-61.
[5] 王瑞鹏, 陈震, 张培松. 糖尿病肾病患者血清中miR-21表达及作用机制[J]. 黑龙江医药科学, 2022, 45(5): 36-38.
[6] 陈月英, 罗晓星, 谢咏梅, 等. 糖尿病肾病患者尿液miR-192的表达及临床意义[J]. 检验医学与临床, 2018, 15(18): 2711-2714.
[7] 晏强, 邹耀霜, 眭维国, 等. MicroRNA在肾脏疾病和生理中的研究进展[J]. 医学综述, 2018, 24(3): 428-433.
[8] 毛玉熠, 李格菲, 韩睿. MicroRNAs调控糖尿病肾病发展的研究进展[J]. 中华临床医师杂志(电子版), 2021, 15(2): 133-138.
[9] 韩琦, 朱伟, 王晓慧, 等. miR-638在糖尿病肾病中的研究进展[J]. 华南国防医学杂志, 2020, 34(8): 591-593.
[10] Cabral, A., Da, S.C.D., Monteiro, S.M., et al. (2019) Differential MicroRNA Profile in Operational Tol-erance: A Potential Role in Favoring Cell Survival. Frontiers in Immunology, 10, Article 740. [Google Scholar] [CrossRef] [PubMed]
[11] Loboda, A., Sobczak, M., Jozkowicz, A. and Dulak, J. (2016) TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation. Mediators of Inflammation, 2016, Article ID: 8319283. [Google Scholar] [CrossRef] [PubMed]
[12] 林森, 周枫林, 胡亚哲. 不同强度运动对糖尿病造模大鼠的血清IL-6、β2-MG及肾脏TGF-β1蛋白表达的影响[J]. 华南国防医学杂志, 2019, 33(5): 295-299.
[13] Xia, Y., Wu, Y., Liu, B., Wang, P.L. and Chen,Y.J. (2014) Downregulation of miR-638 Promotes Invasion and Proliferation by Regulat-ing SOX2 and Induces EMT in NSCLC. FEBS Letters, 588, 2238-2245. [Google Scholar] [CrossRef] [PubMed]
[14] Hu, P., Guan, K., Feng, Y., et al. (2017) miR-638 Inhibits Im-mature Sertoli Cell Growth by Indirectly Inactivating PI3K/AKT Pathway via SPAG1 Gene. Cell Cycle, 16, 2290-2300. [Google Scholar] [CrossRef] [PubMed]
[15] Wang, J., Bai, X., Song, Q., et al. (2015) miR-223 Inhibits Lipid Deposition and Inflammation by Suppressing Toll-Like Receptor 4 Signaling in Macrophages. International Jour-nal of Molecular Sciences, 16, 24965-24982. [Google Scholar] [CrossRef] [PubMed]
[16] Zhuang, G., Meng, C., Guo, X., et al. (2012) A Novel Regulator of Macrophage Activation: miR-223 in Obesity-Associated Adipose Tissue Inflammation. Circulation, 125, 2892-2903. [Google Scholar] [CrossRef] 
[17] You, Z.P., Zhang, Y.L., Li, B.Y., Zhu, X.G. and Shi, K. (2018) Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy. Investigative Ophthalmology & Vis-ual Science, 59, 5558-5563. [Google Scholar] [CrossRef] [PubMed]
[18] Li, Y., Deng, S., Peng, J., et al. (2019) MicroRNA-223 Is Essential for Maintaining Functional β-Cell Mass during Diabetes through Inhibiting Both FOXO1 and SOX6 Pathways. Journal of Biological Chemistry, 294, 10438-10448. [Google Scholar] [CrossRef] 
[19] Wang, L.P., Gao, Y.Z., Song, B., et al. (2019) MicroRNAs in the Progress of Diabetic Nephropathy: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Al-ternative Medicine, 2019, Article ID: 3513179. [Google Scholar] [CrossRef] [PubMed]
[20] 陈娟, 陈拉斯, 陈丽, 等. miR-223-3p/SOX6轴调控糖尿病肾病炎症反应与肾间质纤维化的机制研究[J]. 徐州医科大学学报, 2021, 41(12): 873-880.
[21] Khordadmehr, M., Shahbazi, R., Sadreddini, S. and Baradaran, B. (2019) miR-193: A New Weapon against Cancer. Journal of Cellular Physiology, 234, 16861-16872. [Google Scholar] [CrossRef] [PubMed]
[22] Zhu, Y.N., Ao, Y., Li, B., et al. (2018) De-velopmental Disorder of Podocytes and the Related Renal Diseases. Hereditas, 40, 116-125.
[23] Wan, J., Hou, X., Zhou, Z., et al. (2017) WT1 Ameliorates Podocyte Injury via Repression of EZH2/β-Catenin Pathway in Diabetic Nephropathy. Free Radical Biology and Medicine, 108, 280-299. [Google Scholar] [CrossRef] [PubMed]
[24] Li, J., Chen, Y., Shen, L.L. and Deng, Y.Y. (2019) Im-provement of Membranous Nephropathy by Inhibition of miR-193a to Affect Podocytosis via Targeting WT1. Journal of Cellular Biochemistry, 120, 3438-3446. [Google Scholar] [CrossRef] [PubMed]
[25] Wu, C., Wang, S., Xu, C., et al. (2015) WT1 Enhances Proliferation and Impedes Apoptosis in KRAS Mutant NSCLC via Targeting cMyc. Cellular Physiology and Biochemistry, 35, 647-662. [Google Scholar] [CrossRef] [PubMed]
[26] 高飞, 张欣欣, 杨冰, 等. 微小RNA-193a调控Wilms瘤基因1促进小鼠糖尿病肾病足细胞凋亡[J]. 解剖学报, 2021, 52(5): 728-736.
[27] 白小岗, 王晶, 白婷, 等. miR-9、miR-214在糖尿病肾病中的表达及临床意义[J]. 临床肾脏病杂志, 2021, 21(12): 981-985.
[28] Xiao, Y., Guo, S., Zhang, Y., et al. (2017) Diabetic Nephropathy: Serum miR-9 Confers a Poor Prognosis in and Is Associated with Level Changes of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor. Biotechnology Letters, 39, 1583-1590. [Google Scholar] [CrossRef] [PubMed]
[29] Yue, P.J., Jing, L.J., Zhao, X.Y., Zhu, H.C. and Teng, J.F. (2019) Down-Regulation of Taurine-up-Regulated Gene 1 Attenuates Inflammation by Sponging miR-9-5p via Targeting NF-κB1/p50 in Multiple Sclerosis. Life Sciences, 233, Article ID: 116731. [Google Scholar] [CrossRef] [PubMed]
[30] Shi, Y., Sun, C.F., Ge, W.H., Du, Y.P. and Hu, N.B. (2020) Circu-lar RNA VMA21 Ameliorates Sepsis-Associated Acute Kidney Injury by Regulating miR-9-3p/SMG1/Inflammation Axis and Oxidative Stress. Journal of Cellular and Molecular Medicine, 24, 11397-11408. [Google Scholar] [CrossRef] [PubMed]
[31] Ma, Z., Li, L., Livingston, M.J., et al. (2020) p53/MicroRNA-214/ULK1 Axis Impairs Renal Tubular Autophagy in Diabetic Kidney Disease. Journal of Clinical Investigation, 130, 5011-5026. [Google Scholar] [CrossRef] 
[32] Eissa, S., Matboli, M. and Bekhet, M.M. (2016) Clinical Verification of a Novel Urinary MicroRNA Panal: 133b, -342 and -30 as Biomarkers for Diabetic Nephropathy Identified by Bioinfor-matics Analysis. Biomedicine & Pharmacotherapy, 83, 92-99. [Google Scholar] [CrossRef] [PubMed]

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