自身免疫性脑炎相关痫性发作研究进展
Research Progress in Epileptic Seizures Associated with Autoimmune Encephalitis
DOI: 10.12677/ACM.2023.1351111, PDF,   
作者: 崔绿芳：青海大学研究生院，青海 西宁；王兰桂*：青海大学附属医院神经内科，青海 西宁
关键词: 自身免疫性脑炎；痫性发作；发病机制；临床特征；Autoimmune Encephalitis； Epileptic Seizure； Pathogenesis； Clinical Features
摘要: 癫痫的发病原因复杂，包括遗传、中毒、代谢、感染、以及结构的改变，其中自身免疫性是最常见的原因之一。近年来随着对自身免疫性脑炎认识的加深，临床上越来越多的患者被明确诊断。通常伴有严重的癫痫发作和癫痫持续状态。本文就抗NMDAR、LGI1和GABABR脑炎等临床常见的自身免疫性脑炎相关痫性发作的发病机制和临床特征研究进展进行综述，提高对自身免疫性脑炎相关痫性发作疾病的认识，为临床医生诊断和治疗提供参考价值。
Abstract: The causes of epilepsy are complex, including genetics, poisoning, metabolism, infection, and struc-tural changes, among which autoimmune is one of the most common causes. In recent years, with the deepening of the understanding of autoimmune encephalitis, more and more patients have been diagnosed clinically. It is usually accompanied by severe seizures and continued seizures. This article reviews the progress in the pathogenesis and clinical features of anti-epileptic seizures asso-ciated with autoimmune encephalitis, such as NMDAR, LGI1and GABABR encephalitis, to improve the understanding of epileptic seizures associated with autoimmune encephalitis and provide ref-erence for the diagnosis and treatment of clinicians.
文章引用：崔绿芳, 王兰桂. 自身免疫性脑炎相关痫性发作研究进展[J]. 临床医学进展, 2023, 13(5): 7939-7944. https://doi.org/10.12677/ACM.2023.1351111

参考文献

[1] Moscato, E.H., Peng, X., Jain, A., et al. (2014) Acute Mechanisms Underlying Antibody Effects in An-ti-N-methyl-D-aspartate Receptor Encephalitis. Annals of Neurology, 76, 108-119. [Google Scholar] [CrossRef] [PubMed]
[2] Hughes, E.G., Peng, X., Gleichman, A.J., et al. (2010) Cellular and Synap-tic Mechanisms of Anti-NMDA Receptor Encephalitis. Journal of Neuroscience, 30, 5866-5875. [Google Scholar] [CrossRef] 
[3] Cull-Candy, S., Brickley, S. and Farrant, M. (2001) NMDA Receptor Subunits: Diversity, Development and Disease. Current Opinion in Neurobiology, 11, 327-335. [Google Scholar] [CrossRef] 
[4] Wei, F., Yan, L.M., Su, T., et al. (2017) Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy. Neuroscience Bulletin, 33, 455-477. [Google Scholar] [CrossRef] [PubMed]
[5] Patel, K.H., Chowdhury, Y., Shetty, M., et al. (2020) Anti-N-methyl-d-aspartate Receptor Encephalitis Related Sinus Node Dysfunction and the Lock-Step Phenomenon. American Journal of Medical Case Reports, 8, 503-507. [Google Scholar] [CrossRef] [PubMed]
[6] Dutra, L.A., Abrantes, F., Toso, F.F., et al. (2018) Autoimmune En-cephalitis: A Review of Diagnosis and Treatment. Arquivos de Neuro-Psiquiatria, 76, 41-49. [Google Scholar] [CrossRef] [PubMed]
[7] Dalmau, J., Geis, C. and Graus, F. (2017) Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physi-ological Reviews, 97, 839-887. [Google Scholar] [CrossRef] [PubMed]
[8] Titulaer, M.J., Mccracken, L., Gabilondo, I., et al. (2013) Treat-ment and Prognostic Factors for Long-Term Outcome in Patients with Anti-NMDA Receptor Encephalitis: An Observa-tional Cohort Study. The Lancet Neurology, 12, 157-165. [Google Scholar] [CrossRef] 
[9] Chen, T.S., Lai, M.C., Huang, H.I., et al. (2022) Immunity, Ion Channels and Epilepsy. International Journal of Molecular Sciences, 23, Article No. 6446. [Google Scholar] [CrossRef] [PubMed]
[10] Britton, J. (2016) Chapter 13-Autoimmune Epilepsy. In: Pittock, S.J. and Vincent, A., Eds., Handbook of Clinical Neurology, Vol. 133, 219-245. [Google Scholar] [CrossRef] 
[11] Britton, J. (2016) Autoimmune Epilepsy. In: Hand-book of Clinical Neurology, Vol. 133, Elsevier, Amsterdam, 219-245. [Google Scholar] [CrossRef] 
[12] Van Sonderen, A., Petit-Pedrol, M., Dalmau, J., et al. (2017) The Value of LGI1, Caspr2 and Voltage-Gated Potassium Channel Antibodies in Encephalitis. Nature Reviews Neurology, 13, 290-301. [Google Scholar] [CrossRef] [PubMed]
[13] Wang, Y., Yu, Y., Hu, Y., et al. (2020) Clinical and Electroencephalographic Features of the Seizures in Neuronal Surface Antibody-Associated Autoimmune Encephalitis. Frontiers in Neurology, 11, Article No. 280. [Google Scholar] [CrossRef] [PubMed]
[14] Sagane, K., Ishihama, Y. and Sugimoto, H. (2008) LGI1 and LGI4 Bind to ADAM22, ADAM23 and ADAM11. International Journal of Biological Sciences, 4, 387-396. [Google Scholar] [CrossRef] [PubMed]
[15] Lancaster, E., Huijbers, M.G., Bar, V., et al. (2011) Investigations of caspr2, an Autoantigen of Encephalitis and Neuromyotonia. Annals of Neurology, 69, 303-311. [Google Scholar] [CrossRef] [PubMed]
[16] Fukata, Y., Lovero, K.L., Iwanaga, T., et al. (2010) Disruption of LGI1-Linked Synaptic Complex Causes Abnormal Synaptic Transmission and Epilepsy. Proceedings of the National Academy of Sciences of the United States of America, 107, 3799-3804. [Google Scholar] [CrossRef] [PubMed]
[17] Gaspard, N. (2016) Autoimmune Epilepsy. Continuum (Minneap Minn), 22, 227-245. [Google Scholar] [CrossRef] 
[18] Zhou, Y.D., Lee, S., Jin, Z., et al. (2009) Arrested Matura-tion of Excitatory Synapses in Autosomal Dominant Lateral Temporal Lobe Epilepsy. Nature Medicine, 15, 1208-1214. [Google Scholar] [CrossRef] [PubMed]
[19] Ohkawa, T., Fukata, Y., Yamasaki, M., et al. (2013) Autoantibodies to Epi-lepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Recep-tors. Journal of Neuroscience, 33, 18161-1874. [Google Scholar] [CrossRef] 
[20] Seagar, M., Russier, M., Caillard, O., et al. (2017) LGI1 Tunes Intrinsic Excitability by Regulating the Density of Axonal Kv1 Channels. Proceedings of the National Academy of Sciences of the United States of America, 114, 7719-7724. [Google Scholar] [CrossRef] [PubMed]
[21] Lancaster, E. and Dalmau, J. (2012) Neuronal Autoantigens—Pathogenesis, Associated Disorders and Antibody Testing. Nature Reviews Neurology, 8, 380-390. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, M., Cao, X., Liu, Q., et al. (2017) Clinical Features of Limbic Encephalitis with LGI1 Antibody. Neuropsychiatric Disease and Treatment, 13, 1589-1596. [Google Scholar] [CrossRef] 
[23] Irani, S.R., Michell, A.W., Lang, B., et al. (2011) Faci-obrachial Dystonic Seizures Precede LGI1 Antibody Limbic Encephalitis. Annals of Neurology, 69, 892-900. [Google Scholar] [CrossRef] [PubMed]
[24] Irani, S.R., Stagg, C.J., Schott, J.M., et al. (2013) Faciobrachial Dystonic Seizures: The Influence of Immunotherapy on Seizure Control and Prevention of Cognitive Impairment in a Broadening Phenotype. Brain, 136, 3151-3162. [Google Scholar] [CrossRef] [PubMed]
[25] Van Sonderen, A., Thijs, R.D., Coenders, E.C., et al. (2016) Anti-LGI1 Encephalitis: Clinical Syndrome and Long-Term Follow-Up. Neurology, 87, 1449-1456. [Google Scholar] [CrossRef] 
[26] Benarroch, E.E. (2012) GABAB Receptors: Structure, Functions, and Clinical Implications. Neurology, 78, 578-584. [Google Scholar] [CrossRef] 
[27] Brown, J.T., Davies, C.H. and Randall, A.D. (2007) Syn-aptic Activation of GABA(B) Receptors Regulates Neuronal Network Activity and Entrainment. European Journal of Neuroscience, 25, 2982-2990. [Google Scholar] [CrossRef] [PubMed]
[28] Beghi, E., Giussani, G. and Sander, J.W. (2015) The Natu-ral History and Prognosis of Epilepsy. Epileptic Disorders, 17, 243-253. [Google Scholar] [CrossRef] [PubMed]
[29] Mckay, J.H., Dimberg, E.L. and Lopez Chiriboga, A.S. (2019) A Sys-tematic Review of Gamma-Aminobutyric Acid Receptor Type B Autoimmunity. Neurologia i Neurochirurgia Polska, 53, 1-7. [Google Scholar] [CrossRef] 
[30] Hoftberger, R., Titulaer, M.J., Sabater, L., et al. (2013) Encephali-tis and GABAB Receptor Antibodies: Novel Findings in a New Case Series of 20 Patients. Neurology, 81, 1500-1506. [Google Scholar] [CrossRef] 
[31] Lancaster, E., Lai, M., Peng, X., et al. (2010) Antibodies to the GABA(B) Receptor in Limbic Encephalitis with Seizures: Case Series and Characterisation of the Antigen. The Lan-cet Neurology, 9, 67-76. [Google Scholar] [CrossRef] 
[32] Bettler, B., Kaupmann, K., Mosbacher, J. and Gassmann, M. (2004) Molecular Structure and Physiological Functions of GABAB Receptors. Physiological Reviews, 84, 835-867. [Google Scholar] [CrossRef] [PubMed]

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