消化道恶性肿瘤相关性静脉血栓栓塞的形成机制与影响因素
Formation Mechanism and Influencing Factors of Venous Thromboembolism Associated with Gastrointestinal Cancer
DOI: 10.12677/ACM.2023.1351124, PDF,   
作者: 刘旭丽*：青海大学继续教育学院，青海 西宁；李 燕：青海大学附属医院肿瘤内科，青海 西宁
关键词: 消化道恶性肿瘤；静脉血栓栓塞；形成机制；影响因素；Gastrointestinal Cancer； Venous Thromboembolism； Formation Mechanism； Influencing Factors
摘要: 消化道恶性肿瘤(Gastrointestinal cancer)在我国的发生率及死亡率均居于世界癌种的前十位，应引起人们的高度重视，目前静脉血栓栓塞症(venous thromboembolism, VTE)是恶性肿瘤常见的并发症，已经成为恶性肿瘤患者死亡的第二大病因，直接影响恶性肿瘤患者生活质量和长期预后，本文主要分析消化道恶性肿瘤合并静脉血栓栓塞的发病机制及相关影响因素，临床上对消化道恶性肿瘤患者VTE的发生做出早发现、早诊断、早治疗，以期降低患者的死亡率。
Abstract: Gastrointestinal cancer is covering the top 10 cancers in our country, and its incidence and death rate should arouse people’s close attention. At present, venous thromboembolism is a common complication of all malignancies. It has become the second major cause of death in patients with malignant tumors, which directly affects the quality of life and long-term prognosis of patients with malignant tumors. This paper mainly analyzes the pathogenesis and related influencing factors of digestive tract malignant tumors complicated with venous thromboembolism, so as to make early detection, diagnosis and treatment for the occurrence of VTE in patients with digestive tract malig-nant tumors in clinical practice, in order to reduce the mortality of patients.
文章引用：刘旭丽, 李燕. 消化道恶性肿瘤相关性静脉血栓栓塞的形成机制与影响因素[J]. 临床医学进展, 2023, 13(5): 8026-8033. https://doi.org/10.12677/ACM.2023.1351124

参考文献

[1] 曹毛毛, 陈万青. GLOBOCAN 2020全球癌症统计数据解读[J]. 中国医学前沿杂志(电子版), 2021, 13(3): 63-69.
[2] Ikushima, S., Ono, R., Fukuda, K., Sakayori, M., Awano, N. and Kondo, K. (2016) Trousseau’s Syndrome: Cancer-Associated Thrombosis. Japanese Journal of Clinical Oncology, 46, 204-208. [Google Scholar] [CrossRef] [PubMed]
[3] Heit, J.A., Silverstein, M.D., Mohr, D.N., Petterson, T.M., O’Fallon, W.M. and Melton, L.J. (2000) Risk Factors for Deep Vein Thrombosis and Pulmonary Embolism: A Population-Based Case-Control Study. Archives of Internal Medicine, 160, 809-815. [Google Scholar] [CrossRef] [PubMed]
[4] Levitan, N., Dowlati, A., Remick, S.C., Tahsildar, H.I., Sivinski, L.D., Beyth, R. and Rimm, A.A. (1999) Rates of Initial and Recurrent Thromboembolic Disease among Patients with Malignancy versus Those Without Malignancy. Risk Analysis Using Medicare Claims Data. Medicine (Baltimore), 78, 285-291. [Google Scholar] [CrossRef] [PubMed]
[5] 顾毅. 肿瘤与静脉血栓形成的关系研究进展[J]. 中国癌症杂志, 2002(1): 87-90.
[6] Lip, G.Y., Chin, B.S. and Blann, A.D. (2002) Cancer and the Prothrombotic State. The Lancet Oncology, 3, 27-34. [Google Scholar] [CrossRef] 
[7] Gordon, S.G. and Benson, B. (1989) Analysis of Serum Cancer Procoagulant Activity and Its Possible Use as a Tumor Marker. Thrombosis Research, 56, 431-440. [Google Scholar] [CrossRef] [PubMed]
[8] Dolan, S. and Fitch, M. (2007) The Management of Venous Thromboembolism in Cancer Patients. British Journal of Nursing, 16, 1308-1312. [Google Scholar] [CrossRef] [PubMed]
[9] Zwicker, J.I., Furie, B.C. and Furie, B. (2007) Can-cer-Associated Thrombosis. Critical Reviews in Oncology/Hematology, 62, 126-136. [Google Scholar] [CrossRef] [PubMed]
[10] Noble, S.I., Shelley, M.D., Coles, B., Williams, S.M., Wil-cock, A., Johnson, M.J. and Association for Palliative Medicine for Great Britain and Ireland (2008) Management of Venous Thromboembolism in Patients with Advanced Cancer: A Systematic Review and Meta-Analysis. The Lancet Oncology, 9, 577-584. [Google Scholar] [CrossRef] 
[11] Tawil, N., Bassawon, R. and Rak, J. (2019) Oncogenes and Clotting Factors: The Emerging Role of Tumor Cell Genome and Epigenome in Cancer-Associated Thrombosis. Semi-nars in Thrombosis and Hemostasis, 45, 373-384. [Google Scholar] [CrossRef] [PubMed]
[12] 王昊, 袁建松. 消化道恶性肿瘤并发静脉血栓栓塞的分子机制与风险评估[J]. 中国分子心脏病学杂志, 2021, 21(6): 4380-4383. [Google Scholar] [CrossRef] 
[13] Nash, G.F., Turner, L.F., Scully, M.F. and Kakkar, A.K. (2002) Platelets and Cancer. The Lancet Oncology, 3, 425-430. [Google Scholar] [CrossRef] 
[14] Jain, S., Zuka, M., Liu, J., Russell, S., Dent, J., Guerrero, J., Forsyth, J., Maruszak, B., Gartner, T.K., Felding-Habermann, B. and Ware, J. (2007) Platelet Glycoprotein Ib Alpha Supports Experimental Lung Metastasis. Proceedings of the National Academy of Sciences of the United States of Amer-ica, 104, 9024-9028. [Google Scholar] [CrossRef] [PubMed]
[15] 雷静, 张珲娉, 韩伟, 谭姣, 马永红, 刘莉, 吴志新. 消化道恶性肿瘤高通量基因测序的生物统计分析[J]. 现代肿瘤医学, 2021, 29(23): 4118-4121.
[16] Ades, S., Kumar, S., Alam, M., Goodwin, A., Weckstein, D., Dugan, M., Ashikaga, T., Evans, M., Verschraegen, C. and Holmes, C.E. (2015) Tumor Oncogene (KRAS) Status and Risk of Venous Thrombosis in Patients with Metastatic Colorectal Cancer. Journal of Thrombosis and Haemostasis, 13, 998-1003. [Google Scholar] [CrossRef] [PubMed]
[17] Dunbar, A., Bolton, K.L., Devlin, S.M., Sanchez-Vega, F., Gao, J., Mones, J.V., et al. (2021) Genomic Profiling Identifies Somatic Mutations Predicting Thromboembolic Risk in Patients with Solid Tumors. Blood, 137, 2103-2113. [Google Scholar] [CrossRef] [PubMed]
[18] 邱天, 郭曙光, 方伟, 苏宏斌, 陈匡荣, 张铠. 下肢深静脉血栓发病的高危因素[J]. 中华医学杂志, 2013, 93(29): 2279-2282.
[19] 王辉. 消化系统恶性肿瘤并发静脉血栓栓塞症危险因素分析[D]: [硕士学位论文]. 长春: 吉林大学, 2020.[CrossRef] 
[20] Königsbrügge, O., Lötsch, F., Zielinski, C., Pabinger, I. and Ay, C. (2014) Chronic Kidney Disease in Patients with Cancer and Its Association with Occurrence of Venous Thromboembolism and Mortality. Thrombosis Research, 134, 44-49. [Google Scholar] [CrossRef] [PubMed]
[21] 鲜枫, 谢忠. 恶性肿瘤相关性血栓栓塞研究进展[J]. 中华实用诊断与治疗杂志, 2016, 30(5): 432-434. [Google Scholar] [CrossRef] 
[22] 雷亚飞. 以静脉血栓形成为早期临床表现的消化道恶性肿瘤的临床特点研究[J]. 疾病监测与控制, 2019, 13(6): 436-437+440.
[23] Walker, A.J., Card, T.R., West, J., Crooks, C. and Grainge, M.J. (2013) Incidence of Venous Thromboembolism in Patients with Cancer—A Cohort Study Using Linked United Kingdom Databases. European Journal of Cancer, 49, 1404-1413. [Google Scholar] [CrossRef] [PubMed]
[24] Ferroni, P., Riondino, S., Guadagni, F. and Roselli, M. (2013) Im-pact of Chemotherapy on Venous Thromboembolism: Comment to: Regional Lymph Node Metastases Are a Strong Risk Factor for Venous Thromboembolism: Results from the Vienna Cancer and Thrombosis Study. Haematologica, 98, e153-e154. [Google Scholar] [CrossRef] [PubMed]
[25] Ahlbrecht, J., Dickmann, B., Ay, C., Dunkler, D., et al. (2012) Tumor Grade Is Associated with Venous Thromboembolism in Patients with Cancer: Results from the Vienna Cancer and Thrombosis Study. Journal of Clinical Oncology, 30, 3870-3875. [Google Scholar] [CrossRef] 
[26] Faiz, A.S., Khan, I., Beckman, M.G., Bockenstedt, P., Heit, J.A., et al. (2015) Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism. Thrombosis Research, 136, 535-541. [Google Scholar] [CrossRef] [PubMed]
[27] Khorana, A.A., Kuderer, N.M., Culakova, E., Lyman, G.H. and Francis, C.W. (2008) Development and Validation of a Predictive Model for Chemotherapy-Associated Thrombosis. Blood, 111, 4902-4907. [Google Scholar] [CrossRef] [PubMed]
[28] 张倩倩. 恶性肿瘤合并静脉血栓栓塞的危险因素分析[D]: [硕士学位论文]. 新乡: 新乡医学院, 2020.[CrossRef] 
[29] Ay, C., Vormittag, R., Dunkler, D., Simanek, R., Chiriac, A.L., Drach, J., et al. (2009) D-Dimer and Prothrombin Fragment 1 + 2 Predict Venous Thromboembolism in Patients with Cancer: Results from the Vienna Cancer and Thrombosis Study. Journal of Clinical Oncology, 27, 4124-4129. [Google Scholar] [CrossRef] 
[30] Masuda, T., Hayashi, N., Iguchi, T., Ito, S., Eguchi, H. and Mi-mori, K. (2016) Clinical and Biological Significance of Circulating Tumor Cells in Cancer. Molecular Oncology, 10, 408-417. [Google Scholar] [CrossRef] [PubMed]
[31] Bettegowda, C., Sausen, M., Leary, R.J., et al. (2014) Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies. Science Translational Medicine, 6, 224ra24.
[32] Hoshino, A., Costa-Silva, B., Shen, T.L., et al. (2015) Tumour Exosome Integrins Determine Organo-tropic Metastasis. Nature, 527, 329-335.
[33] Allard, W.J., Matera, J., Miller, M.C., Repollet, M., Connelly, M.C., Rao, C., Tibbe, A.G., Uhr, J.W. and Terstappen, L.W. (2004) Tumor Cells Circulate in the Peripheral Blood of All Major Car-cinomas but Not in Healthy Subjects or Patients with Nonmalignant Diseases. Clinical Cancer Research, 10, 6897-6904. [Google Scholar] [CrossRef] 
[34] Ignatiadis, M., Riethdorf, S., Bidard, F.C., et al. (2014) In-ternational Study on Inter-Reader Variability for Circulating Tumor Cells in Breast Cancer. Breast Cancer Research, 16, R43.
[35] 欧洋. 胃癌患者外周血循环肿瘤细胞检测及临床意义的研究[D]: [硕士学位论文]. 济南: 济南大学, 2019.
[36] Hiraiwa, K., Takeuchi, H., Hasegawa, H., et al. (2008) Clinical Significance of Circulating Tumor Cells in Blood from Patients with Gastrointestinal Cancers. Annals of Surgical Oncology, 15, 3092-3100. [Google Scholar] [CrossRef] [PubMed]
[37] Okabe, H., Tsunoda, S., Hosogi, H., Hisamori, S., Tanaka, E., Tanaka, S. and Sakai, Y. (2015) Circulating Tumor Cells as an Independent Predictor of Survival in Advanced Gastric Cancer. Annals of Surgical Oncology, 22, 3954-3961. [Google Scholar] [CrossRef] [PubMed]
[38] Lee, A.M., Tormoen, G.W., Kanso, E., et al. (2012) Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow. Frontiers in Oncology, 2, Article No. 108. [Google Scholar] [CrossRef] [PubMed]
[39] Kasthuri, R.S., Taubman, M.B., Mackman, N., et al. (2009) Role of Tissue Factor in Cancer. Journal of Clinical Oncology, 27, 4834-4838. [Google Scholar] [CrossRef] 
[40] Malik, G., Knowles, L.M., Dhir, R., et al. (2010) Plasma Fibron-ectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion. Cancer Research, 70, 4327-4334. [Google Scholar] [CrossRef] 
[41] 王晓康, 袁锦权. 肺癌患者术后血液高凝状态与外周血循环肿瘤细胞的相关性分析[J]. 中国当代医药, 2021, 28(29): 13-16.
[42] 汤雨. 老年前列腺癌患者外周血循环肿瘤细胞与临床特征的相关性研究[D]: [硕士学位论文]. 苏州: 苏州大学, 2017.

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