预测阿尔茨海默症的新方法：人格特征角色
A New Method for Predicting Alzheimer’s Disease: Personality Traits and Roles
DOI: 10.12677/ACM.2023.1351170, PDF,   
作者: 孙婷婷：金华高等研究院中医康复研究所，浙江 金华
关键词: 阿尔茨海默症；人格特征；疾病预防；Alzheimer’s Disease； Personality Characteristics； Disease Prevention
摘要: 阿尔兹海默症(Alzheimer’s Disease)是一种持续存在的中枢退行性疾病。随着病情发展，患者最终会失去吞咽等基本的生活能力，走向死亡。目前全球范围内没有有效的治疗方法，所以良好的预防很重要。多项研究显示，影响阿尔茨海默症的危险因素分为遗传和环境两个方面，关于阿尔茨海默症的进程如何受到人格、心理和其他社会因素的影响一直是研究的重点。本文将通过论述阿尔茨海默症与人格特征之间的关系，为阿尔茨海默症的防病治病提供参考。
Abstract: Alzheimer’s Disease (AD) is a persistent degenerative disease of the central nervous system. With the development of the disease, AD patients will eventually lose the basic living ability such as swallowing, leading to death. Currently, there is no effective treatment worldwide, so good preven-tion is very important. Many studies have shown that risk factors affecting AD can be divided into genetic and environmental aspects, and how social factors such as personality and psychology affect AD has always been the focus of research. By discussing the relationship between AD and personal-ity characteristics, this paper will provide references for disease prevention and treatment of Alz-heimer’s disease.
文章引用：孙婷婷. 预测阿尔茨海默症的新方法：人格特征角色[J]. 临床医学进展, 2023, 13(5): 8367-8372. https://doi.org/10.12677/ACM.2023.1351170

参考文献

[1] Scheltens, P., De Strooper, B., Kivipelto, M., et al. (2021) Alzheimer’s Disease. The Lancet, 397, 1577-1590. [Google Scholar] [CrossRef] 
[2] 那龙. 老年痴呆与C型人格特征关系研究[J]. 山西职工医学院学报, 2018, 28(2): 64-66.
[3] 石素琴, 石琼. 阿尔茨海默症的危险因素概述[J]. 环境卫生学杂志, 2019, 9(1): 85-91.
[4] 田金洲, 时晶, 张学凯, 等. 2011年美国阿尔茨海默病最新诊断标准解读[J]. 中国医学前沿杂志(电子版), 2011, 3(4): 91-100.
[5] Xu, H., Ye, Y., Zhang, X., et al. (2016) Military Experience Helps Setting Rea-sonable Personality Characteristics but Does Not Alter the Criminal Behavior-Related Impression of Negative Parental Experience and Alcoholism in a Chinese Population. Psychiatry Research, 244, 130-138. [Google Scholar] [CrossRef] [PubMed]
[6] Alacreu-Crespo, A., Olie, E., Seneque, M., et al. (2019) Deci-sion-Making Skills Moderate the Relationship between Psychological and Physical Pain with Suicidal Behavior in De-pressed Patients. Psychotherapy Psychosomatics, 88, 190-191. [Google Scholar] [CrossRef] [PubMed]
[7] Mendez, M.F. (2017) Early-Onset Alzheimer Disease. Neurologic Clinics, 35, 263-281. [Google Scholar] [CrossRef] [PubMed]
[8] Alzheimer’s Association (2015) 2015 Alzheimer’s Disease Facts and Figures. Alzheimer’s & Dementia, 11, 332-384. [Google Scholar] [CrossRef] [PubMed]
[9] Blennow, K., de Leon, M.J. and Zetterberg, H. (2006) Alzheimer’s Disease. The Lancet, 368, 387-403. [Google Scholar] [CrossRef] 
[10] Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D. and Jones, E. (2011) Alzheimer’s Disease. The Lancet, 377, 1019-1031. [Google Scholar] [CrossRef] 
[11] Bartzokis, G. (2011) Alzheimer’s Disease as Homeostatic Responses to Age-Related Myelin Breakdown. Neurobiology of Aging, 32, 1341-1371. [Google Scholar] [CrossRef] [PubMed]
[12] 秦俊法. 微量元素与阿尔茨海默病(1) [J]. 广东微量元素科学, 2015, 22(5): 1-17.
[13] Cardoso, B.R., Cominetti, C. and Cozzolino, S.M.F. (2013) Importance and Man-agement of Micronutrient Deficiencies in Patients with Alzheimer’s Disease. Clinical Interventions in Aging, 8, 531-542. [Google Scholar] [CrossRef] 
[14] 侯焕喜, 王训. 阿尔茨海默病与微量元素及氧化应激的关系[J]. 中西医结合心脑血管病杂志, 2014, 12(8): 983-985.
[15] Masoud, A.M., Bihaqi, S.W., Machan, J.T., et al. (2016) Ear-ly-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer’s Disease. Journal of Alzheimer’s Disease, 51, 1257-1264. [Google Scholar] [CrossRef] 
[16] 崔增伟, 陈继彬. 阿尔茨海默病流行病学特征及危险因素研究进展[J]. 慢性病学杂志, 2014, 15(1): 52-57.
[17] 贾建平. 痴呆与轻度认知障碍的流行病学、发病机制和诊治应用研究——2013年度国家科学技术进步二等奖[J]. 首都医科大学学报, 2014, 35(1): 1-5.
[18] Wang, W., Wu, Y.X. and Peng, Z.G. (2000) Test of Sensation Seeking in Chinese Sample. Personality and Individual Differences, 28, 169-179. [Google Scholar] [CrossRef] 
[19] 黄国平, 张亚林. 创伤后应激障碍与单胺类神经递质[J]. 中国行为医学科学, 2006, 15(3): 286-288.
[20] Herrmann, M.J., Sonnek, G., Weijers, H.G., et al. (2002) Electro-physiological Indication for a Link between Serotonergic Neurotransmission and Personality in Alcoholism. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 26, 157-161. [Google Scholar] [CrossRef] 
[21] Reuter, M., Netter, P., Toll, C. and Hennig, J. (2002) Do-pamine Agonist and Antagonist Responders as Related to Types of Nicotine Craving and Facets of Extraversion. Pro-gress in Neuro-Psychopharmacology & Biological Psychiatry, 26, 845-853. [Google Scholar] [CrossRef] 
[22] Garpenstrand, H., Longato-Stadler, E., af Klinteberg, B., et al. (2002) Low Platelet Monoamine Oxidase Activity in Swedish Imprisoned Criminal Offenders. European Neuropsycho-pharmacology, 12, 135-140. [Google Scholar] [CrossRef] 
[23] Zuckerman, M. (1984) Sensation Seeking: A Comparative Approach to a Human Trait. The Behavioral and Brain Sciences, 12, 413-417. [Google Scholar] [CrossRef] 
[24] Ebstein, R.P., Novick, O. and Umansky, R. (1996) Dopamine D4 Receptor (D4DR) Exon III Polymorphism Associated with the Human Personality Trait of Novelty-Seeking. Nature Genetics, 12, 78-80. [Google Scholar] [CrossRef] [PubMed]
[25] Livesley, W. (2005) Behavioral and Molecular Genetic Contributions to a Dimensional Classification of Personality Disorder. Journal of Personality Disorders, 19, 131-155. [Google Scholar] [CrossRef] [PubMed]
[26] 彭立威. 试论生态化人格及推进人格生态化的意义[J]. 中国人口∙资源与环境, 2017, 22(3): 170-174.
[27] 任廷格, 张帆. 任应秋讲黄帝内经(素问) [M]. 北京: 全国中医药出版社, 2014: 706.
[28] 刘晓雯, 吕学玉, 汪卫东. 中医学整体思维对人格系统发展理论的影响(连载一)——人格系统与遗传、环境系统[J]. 世界中医药, 2019, 14(3): 758-760.
[29] Olson, D.H., Russell, C.S. and Sprenkle, D.H. (1983) Circumplex Model of Marital and Family Systems: VI. Theoretical Update. Family Process, 22, 69-83. [Google Scholar] [CrossRef] [PubMed]
[30] 黄诗雅, 周海山, 张超宇, 牟劲松, 梁鸿迪, 张彩霞. 家庭亲密度和适应性与学龄前儿童饮食行为的关联[J]. 中山大学学报(医学科学版): 1-7.
[31] 汪燕妮, 薛红丽, 陈倩. 家庭亲密度和适应性对学龄前儿童行为问题的影响[J]. 中国当代儿科杂志, 2016, 18(5): 421-425.
[32] Crea, T.M., Chan, K. and Barth, R.P. (2014) Family Environment and Attention-Deficit/Hyperactivity Disorder in Adopted Children: Associations with Family Cohesion and Adaptability. Child: Care, Health and Development, 40, 853-862. [Google Scholar] [CrossRef] [PubMed]
[33] 张小琴, 张罡. 家庭亲密度和适应性对学龄期哮喘儿童行为问题的影响[J]. 中国健康心理学杂志, 2018, 26(8): 1139-1143.
[34] Strikwerda-Brown, C. (2022) Chicken or Egg? Untangling the Associations between Personality Traits and Alzheimer’s Disease Pathology. Biological Psychiatry, 91, E17-E19. [Google Scholar] [CrossRef] [PubMed]

为你推荐