胞内自组装纳米材料及其生物医学应用
Intracellularly Self-Assembled Nanomaterials and Their Biomedical Applications
摘要: 近年来，通过模仿自然界中生物大分子基元的自组装行为，科学家将人造基元送入细胞内部并原位构筑出一系列胞内自组装纳米材料。这类材料不易被细胞外排，可在细胞内长时保留，在靶向治疗、细胞成像及传感等生物医学领域具有广阔的应用前景。本文分类概述了目前常见胞内自组装纳米材料的基元类型、设计方法、组装机制及生物医学应用，并对这类材料未来的发展方向进行了展望。
Abstract: Inspired by natural self-assembly of biomacromolecules, a range of synthetic building units have been developed in recent years, with the goal of constructing non-natural assemblies inside living cells. These materials are not easy to be exocytosed by the cells, and thus have long intracel-lular retention time, holding great potential for various biomedical applications such as targeted therapy and cell imaging. This review summarizes common intracellularly self-assembled nano-materials, introduces their biomedical applications, and prospects their development in future.
文章引用：侯德隆, 徐勇, 陈意, 范浩军. 胞内自组装纳米材料及其生物医学应用[J]. 材料科学, 2023, 13(5): 379-386. https://doi.org/10.12677/MS.2023.135042

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