儿童发热门诊患者血清淀粉样蛋白A对NLR影响的研究

Study on the Effect of Serum Amyloid Protein A on NLR in Children from Fever Outpatients

摘要: 目的：探讨儿童发热门诊患者不同性别及年龄组的血清淀粉样蛋白A (SAA)对中性粒细胞与淋巴细胞比值(NLR)结果的影响。方法：回顾性分析济宁医学院附属医院儿童发热门诊399例患者资料，并收集SAA及NLR测定数据，对所有结果进行统计学分析。结果：不同浓度的SAA对NLR具有显著不同的影响(P < 0.05)，和低浓度SAA组(36.48 ± 15.59)相比较，中浓度组SAA (78.68 ± 10.58)中NLR增加1.23 (P < 0.05)，而高浓度组SAA (128.22 ± 23.41)和低浓度SAA组相比较NLR增加2.69 (P < 0.05)。性别对NLR无影响(P > 0.05)。和低年龄组比较，中年龄组NLR增加1.72 (P < 0.05)，而高年龄组NLR则增加2.54 (P < 0.05)。NLR和SAA存在正相关(r = 0.487)，NLR随着SAA的增加而增加。结论：儿童发热门诊患者SAA与NLR增高存在一定的正相关关系，并受不同年龄及不同浓度的SAA的影响。

Abstract: Objective: To investigate the effect of serum amyloid A (SAA) levels on neutrophil to lymphocyte ra-tio (NLR) in different gender and age groups of pediatric fever outpatient patients. Method: A ret-rospective analysis was conducted on the data of 399 patients from the Children’s Fever Clinic of Af-filiated Hospital of Jining Medical University, and SAA and NLR data were collected for statistical analysis. The results showed that different concentrations of SAA had significantly different effects on NLR (P < 0.05). Compared with the low concentration SAA group (36.48 ± 15.59), the NLR in the medium concentration group (78.68 ± 10.58) increased by 1.23 (P < 0.05), while the NLR in the high concentration group (128.22 ± 23.41) increased by 2.69 (P < 0.05). Gender had no effect on NLR (P > 0.05). Compared with the low age group, the NLR of the middle age group increased by 1.72 (P < 0.05), while the NLR of the high age group increased by 2.54 (P < 0.05). There is a positive correlation between NLR and SAA (r = 0.487), and NLR increases with the increase of SAA. Conclu-sion: There is a certain positive correlation between SAA and increased NLR in pediatric fever out-patient patients, and it is influenced by different ages and concentrations of SAA.