痛风性关节炎动物模型研究进展

Research Progress of Animal Models of Gouty Arthritis

摘要: 痛风，一种晶体沉积性慢性疾病，是由机体内持续升高的血清尿酸浓度(尿酸在人体内的饱和阈值为6.8 mg/dL)引起单钠尿酸盐结晶沉积在关节和非关节结构中。随着经济快速发展和人群生活方式的变化，痛风的发病率在全球范围内逐年提高，给人们的生活健康带来极大的影响，增加了许多国家的疾病负担。因此，关于痛风的深入研究和相关药物的开发受到广泛的关注。基于动物模型进行体内研究痛风性关节炎的病理生理过程和药物筛选则是新药研发前的重要环节。本文将归纳总结目前研究中采用的各种痛风性关节炎动物模型，分析讨论各种造模方法的特点，为今后该疾病的进一步研究提供模型参考。

Abstract: Gout, a crystal-depositing chronic disease, is caused by the deposition of monosodium urate crystals in joint and non-joint structures caused by continuously elevated serum uric acid concentration in the body (the saturation threshold of uric acid in the human body is 6.8 mg/dL). With the rapid economic development and changes in people’s lifestyles, the incidence of gout is increasing year by year worldwide, which has had a great impact on people’s lives and health and increased the burden of disease in many countries. Therefore, indepth research on gout and the development of related drugs have received extensive attention. In vivo research on the pathophysiological process of gouty arthritis based on animal models and drug screening are important steps before new drug development. This article will summarize the various animal models of gouty arthritis used in the current research, analyze and discuss the characteristics of various modeling methods, and provide model reference for further research on this disease in the future.