ENPP6在乳腺癌中的表达特征和临床意义

The Expression Characteristics and Clinical Significance of ENPP6 in Breast Cancer

摘要: 目的：探究ENPP6在乳腺癌中的表达情况和预后意义。方法：我们使用TIMER数据库计算ENPP6在泛癌中的表达情况和每种乳腺癌亚型中ENPP6表达与多种免疫细胞浸润之间的关系。根据ENPP6表达将所有乳腺癌患者分成高表达组和低表达组，比较二者的总体生存上的差异。绘制1年、3年和5年预后的ROC曲线。结果：ENPP6在多种癌症中下调表达。K-M分析显示ENPP6高表达组预后比低表达组较好。免疫浸润分析显示ENPP6对basal和luminal乳腺癌中多种免疫细胞浸润水平呈正相关。ROC曲线下面积大小(AUC)分别为0.61 (1年)、0.60 (3年)和0.60 (5年)。结论：ENPP6表达水平与乳腺癌的发生、预后和免疫浸润水平相关，表明它可以用作乳腺癌的生物标志物。

Abstract: Objective: To investigate the expression and prognostic significance of ENPP6 in breast cancer. Methods: We used the TIMER database to calculate the expression of ENPP6 in pan-cancer and the relationship between ENPP6 expression and multiple immune cell infiltration in each breast cancer subtype. All breast cancer patients were divided into high and low expression groups according to ENPP6 expression, and the differences in overall survival between the two were compared. ROC curves were plotted for 1-, 3-, and 5-year prognoses. Results: ENPP6 was down-regulated in a varie-ty of cancers. K-M analysis showed that the ENPP6 high expression group had a better prognosis than the low expression group. Immune infiltration analysis showed a positive correlation between ENPP6 on the level of multiple immune cell infiltration in basal and luminal breast cancers. The ar-ea under the ROC curve size (AUC) was 0.61 (1 year), 0.60 (3 years) and 0.60 (5 years), respectively. Conclusion: ENPP6 expression levels correlated with breast cancer development, prognosis and immune infiltration levels, indicating that it can be used as a biomarker for breast cancer.