脓毒症相关性急性肺损伤的发病机制及研究进展
Pathogenesis and Research Progress of Acute Lung Injury Associated with Sepsis
DOI: 10.12677/ACM.2023.1351210, PDF,  被引量   
作者: 王 稳:青海大学研究生院,青海 西宁;吕荣华:青海大学附属医院急诊内科,青海 西宁
关键词: 脓毒症急性肺损伤发病机制Sepsis Acute Lung Injury Pathogenesis
摘要: 脓毒症是导致患者入住重症监护病房(ICU)的主要病因之一。虽然脓毒症及脓毒性休克的诊疗已取得了一定的进展,但其病死率仍然居高不下。急性肺损伤是多种因素引起的肺毛细血管内皮细胞及肺泡上皮细胞损伤造成的非心源性肺水肿,临床主要表现为难治性的低氧血症和呼吸窘迫等特征。在脓毒症中,肺脏是最易受累的靶器官,因此脓毒症患者极易发生急性肺损伤,其预后较差。脓毒症相关肺损伤的发病机制复杂,目前尚无研究明确其发病机制,本文就近年来脓毒症急性肺损伤的发病机制进行综述,旨在为其临床治疗提供理论支持。
Abstract: Sepsis is one of the main causes of admission to intensive care units (ICU). Although progress has been made in the diagnosis and treatment of sepsis and septic shock, the fatality rate is still high. Acute lung injury is non-cardiogenic pulmonary edema caused by injury of pulmonary capillary endothelial cells and alveolar epithelial cells caused by various factors. The clinical manifestations are mainly refractory hypoxemia and respiratory distress. Lung is the most easily affected target organ in sepsis, so patients with sepsis are prone to acute lung injury and have a poor prognosis. The pathogenesis of sepsis related lung injury is complex, and there is no clear research on its pathogenesis. This paper reviews the pathogenesis of sepsis acute lung injury in recent years, aim-ing to provide theoretical support for its clinical treatment.
文章引用:王稳, 吕荣华. 脓毒症相关性急性肺损伤的发病机制及研究进展[J]. 临床医学进展, 2023, 13(5): 8657-8663. https://doi.org/10.12677/ACM.2023.1351210

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