维持性血液透析患者血清25(OH)D与难治性高血压的相关分析
Correlation Analysis between Serum 25(OH)D and Refractory Hypertension in Maintenance Hemodialysis Patients
摘要: 难治性高血压在维持性血液透析患者中非常常见,严重威胁患者的预后和生活质量。其发病机制复杂,研究发现血清25(OH)D与难治性高血压相关,维生素D通过抑制肾素基因表达、调节微炎症状态等与血液透析患者难治性高血压相关,为难治性高血压的治疗提供了新思路。
Abstract: Refractory hypertension is very common in maintenance hemodialysis patients and seriously threatens their prognosis and quality of life. Its pathogenesis is complex, and studies have found that serum 25(OH)D is related to refractory hypertension. Vitamin D is related to refractory hyper-tension by inhibiting renin gene expression and regulating the microinflammatory state of hemodi-alysis patients, which provides a new idea for the treatment of refractory hypertension.
文章引用:张英儿, 巴应贵. 维持性血液透析患者血清25(OH)D与难治性高血压的相关分析[J]. 临床医学进展, 2023, 13(5): 8790-8794. https://doi.org/10.12677/ACM.2023.1351228

参考文献

[1] 中国高血压防治指南修订委员会. 中国高血压防治指南(2018) [J]. 中国心血管杂志, 2019, 24(1): 24-56.
[2] 王聪水, 余振球. 难治性高血压诊断更新与治疗进展[J]. 医学研究杂志, 2017, 46(6): 189-192.
[3] Calhoun, D.A., Jones, D., Textor, S., et al. (2008) Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Re-search. Circulation, 117, 510-526. [Google Scholar] [CrossRef
[4] Siddiqui, M. and Calhoun, D.A. (2016) Refractory versus Resistant Hypertension. Current Opinion in Nephrology and Hypertension, 26, 14-19. [Google Scholar] [CrossRef
[5] Kumar, N., Calhoun, D.A. and Dudenbostel, T. (2013) Management of Patients with Resistant Hypertension: Current Treatment Options. Integrated Blood Pressure Control, 6, 139-151. [Google Scholar] [CrossRef
[6] Carmine, Z. and Francesca, M. (1979) Does a Vitamin D Boost Help in Resistant Hypertension Control? Hypertension, 63, 672-674. [Google Scholar] [CrossRef
[7] 周岩芬, 杜玉花. 难治性高血压左心室肥厚与交感神经兴奋性关系的临床研究[J]. 国际心血管病杂志, 2017, 44(1): 53-55.
[8] Tanaka, S., Ninomiya, T., Hiya-muta, H., et al. (2019) Apparent Treatment Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study. Scientific Reports, 9, Article No. 1043. [Google Scholar] [CrossRef] [PubMed]
[9] 甘林望, 李乾程, 温向琼, 等. 维持性血液透析合并高血压患者难治性高血压的影响因素分析[J]. 中国现代医学杂志, 2016, 26(5): 105-109.
[10] Kantauskaite, M., Vonend, O., Yakoub, M., Heilmann, P., Maifeld, A., Minko, P., Schimmöller, L., Antoch, G., Müller, D.N., Schmidt, C., Duvnjak, B., Zierhut, U., Potthoff, S.A., Rump, L.C., Fischer, J.C. and Stegbauer, J. (2023) The Effect of Renal Dener-vation on T Cells in Patients with Resistant Hypertension. International Journal of Molecular Sciences, 24, 2493. [Google Scholar] [CrossRef] [PubMed]
[11] 庞博, 佟雪, 孙林, 杨波. 维持性血液透析合并难治性高血压的治疗进展[J]. 医学综述, 2021, 27(12): 2371-2376.
[12] 夏运风, 甘华. 尿毒症难治性高血压的发生机制[J]. 山西医科大学学报, 2002, 33(5): 479-481.
[13] Reiss, A.B., Voloshyna, I., De Leon, J., Miyawaki, N. and Mattana, J. (2015) Cholesterol Metabolism in CKD. American Journal of Kidney Diseases, 66, 1071-1082. [Google Scholar] [CrossRef] [PubMed]
[14] Choi, H.Y., Park, H.C. and Ha, S.K. (2014) How Do We Manage Coronary Artery Disease in Patients with CKD and ESRD? Electrolyte Blood Press, 12, 41-54. [Google Scholar] [CrossRef
[15] Stojanovic, V., Doronjski, A., Milak, G. and Barisic, N. (2013) Id-iopathic Arterial Calcification of Infancy—Peritoneal Dialysis for Treatment of Hypertension. Fetal and Pediatric Pa-thology, 32, 443-447. [Google Scholar] [CrossRef] [PubMed]
[16] Masuo, K., Lambert, G.W., Esler, M.D., et al. (2010) The Role of Sympathetic Nervous Activity in Renal Injury and Endstage Renal Disease. Hypertension Research, 33, 521-528. [Google Scholar] [CrossRef] [PubMed]
[17] Koomans, H.A., Blankestijn, P.J. and Joles, J.A. (2004) Sympathetic Hy-peractivity in Chronic Renal Failure: A Wake-Up Call. Journal of the American Society of Nephrology, 15, 524-537. [Google Scholar] [CrossRef
[18] Zilch, O., Vos, P.F., Oey, P.L., et al. (2007) Sympa-thetic Hyperactivity in Haemodialysis Patients Is Reduced by Short Daily Haemodialysis. Journal of Hypertension, 25, 1285-1289. [Google Scholar] [CrossRef
[19] Agarwal, R., Flynn, J., Pogue, V., et al. (2014) Assessment and Management of Hypertension in Patients on Dialysis. Journal of the American Society of Nephrology, 25, 1630-1646. [Google Scholar] [CrossRef
[20] Shafi, T.1., Waheed, S. and Zager, P.G. (2014) Hypertension in Hemodialysis Patients: An Opinion-Based Update. Seminars in Dialysis, 27, 146-153. [Google Scholar] [CrossRef] [PubMed]
[21] Kheiri, B., Abdalla, A., Osman, M., et al. (2018) Vitamin D deficiency and Risk of Cardiovascular Diseases: A Narrative Review. Clinical Hypertension, 24, Article No. 9. [Google Scholar] [CrossRef] [PubMed]
[22] Banerjee, S., Basu, S., Akhtar, S., et al. (2019) Free Vitamin D Levels in Steroid-Sensitive Nephrotic Syndrome and Healthy Controls. Pediatric Nephrology, 35, 447-454 [Google Scholar] [CrossRef] [PubMed]
[23] Lavie, C.J., Lee, J.H. and Milani, R.V. (2011) Vitamin D and Cardiovas-Cular Disease Will It Live up to Its Hype? Journal of the American College of Cardiology, 58, 1547-1556. [Google Scholar] [CrossRef] [PubMed]
[24] 陈秀炎, 张坤英, 赵军, 孔超. 1,25(OH)2D3减轻维持性血液透析患者微炎症状态的作用机制研究进展[J]. 中国血液净化, 2021, 20(9): 617-620.
[25] Lee, J.H., O’Keefe, J.H., Bell, D., Hensrud, D.D. and Holick, M.F. (2008) Vitamin D Deficiency an Important, Common, and Easily Treatable Cardiovascular Risk Factor? Journal of the American College of Cardiology, 52, 1949-1956. [Google Scholar] [CrossRef] [PubMed]
[26] 陈红艳, 黄柏勇. 120例维持性血液透析患者维生素D水平及相关因素分析[J]. 实用医药杂志, 2015, 32(10): 912-913. [Google Scholar] [CrossRef
[27] Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H.F., Lieben, L., Mathieu, C. and Demay, M. (2008) Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice. Endocrine Reviews, 29, 726-776. [Google Scholar] [CrossRef] [PubMed]
[28] Xiang, W., Kong, J., Chen, S., et al. (2005) Cardiac Hypertrophy in Vitamin D Receptor Knockout Mice: Role of the Systemic and Cardiac Renin-Angiotensin Systems. American Journal of Physiology-Endocrinology and Metabolism, 288, E125-E132. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, Z., Chen, F., Li, J., et al. (2018) 1,25(OH)2D3 Suppresses Proinflammatory Responses by Inhibiting Th1 Cell Differentiation and Cytokine Production through the JAK/STAT Pathway. American Journal of Translational Research, 10, 2737-2746.
[30] Jiang, S., Huang, L., Zhang, W. and Zhang, H. (2021) Vitamin D/VDR in Acute Kidney Injury: A Potential Therapeutic Target. Current Medicinal Chemistry, 28, 3865-3876. [Google Scholar] [CrossRef] [PubMed]
[31] 刘宏超, 尹忠诚. 维持性血液透析并发25-羟维生素D缺乏及预后不良的危险因素[J]. 山东医药, 2022, 62(6): 66-68.
[32] 李小艳, 丁洁, 王学晶, 等. 嘌呤霉素氨基核苷大鼠肾病模型与阿霉素大鼠肾病模型的比较[J]. 中华肾脏病杂志, 2013, 29(2): 137-141.