脂质代谢在Th17细胞分化中的参与和调节作用
The Role and Regulation of Lipid Metabolism in Th17 Cell Differentiation
DOI: 10.12677/PI.2023.123031, PDF,   
作者: 徐丹蕾, 戴 岳*：中国药科大学中药学院，江苏 南京
关键词: 脂质代谢；Th17细胞；分化；自身免疫性疾病；Lipid Metabolism； Th17 Cells； Differentiation； Autoimmune Diseases
摘要: 脂质，如脂肪酸、胆固醇、磷脂和甘油三酯等，在生物体内扮演着至关重要的角色，是细胞膜的重要构成成分，同时参与信号传导和能量供给。脂质代谢是Th17细胞的重要代谢方式之一，脂质合成有利于Th17细胞分化，而调控脂质代谢可控制Th17细胞的命运与功能。通过靶向脂质代谢抑制Th17细胞分化具有改善多种自身免疫性疾病的潜力。本文综述脂肪酸、胆固醇、磷脂和甘油三酯代谢在调节Th17细胞分化中的参与和重要性。
Abstract: Lipids, including fatty acids, cholesterol, phospholipid and triglycerides, play a vital role in living organisms, which are not only important components of cell membranes, but also participate in signal transduction and energy supply. Lipid metabolism is one of the important metabolic modes of Th17 cells, lipid synthesis is conducive to Th17 cell differentiation, and regulation of lipid metabolism can control the fate and function of Th17 cells. Inhibition of Th17 cell differentiation by targeting lipid metabolism has the potential to ameliorate several autoimmune diseases. This paper summarizes the role and importance of fatty acid, cholesterol, phospholipid and triglyceride metabolism in regulating Th17 cell differentiation.
文章引用：徐丹蕾, 戴岳. 脂质代谢在Th17细胞分化中的参与和调节作用[J]. 药物资讯, 2023, 12(3): 248-254. https://doi.org/10.12677/PI.2023.123031

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