短链脂肪酸对类风湿性关节炎的改善作用及中药的调控

Ameliorative Effect of Short Chain Fatty Acids on Rheumatoid Arthritis and Regulation of Traditional Chinese Medicines

摘要: 类风湿性关节炎是一种有“不死的癌症”之称的慢性全身性免疫疾病，是临床多发且难治的关节运动性疾病之一。短链脂肪酸是肠道菌群的重要代谢产物，具有抑制炎症和调节免疫等生物活性，对类风湿性关节炎具有改善作用。此外，许多中药可通过调控肠道菌群促进短链脂肪酸产生，呈现抗关节炎效应。本文从短链脂肪酸在类风湿性关节炎疾病状态下的变化，对疾病的改善作用和机制，中药调控短链脂肪酸治疗类风湿性关节炎以及短链脂肪酸的应用等方面进行综述，为认识类风湿性关节炎的病机、促进相关药物的研发及阐明中药的作用机制提供参考。

Abstract: Rheumatoid arthritis (RA) is a chronic systemic immune disease known as “cancer that never dies”. It is one of the most common and refractory joint motor diseases in clinic. Short-chain fatty acids are important metabolites of intestinal flora, which have biological activities such as inhibiting inflammation and regulating immunity, and can improve rheumatoid arthritis. In addition, many traditional Chinese medicines can promote the production of short-chain fatty acids by regulating intestinal flora, showing anti-arthritis effect. In this paper, the changes of short-chain fatty acids in the disease state of rheumatoid arthritis, the improvement effect and mechanism of the disease, the regulation of short-chain fatty acids by Chinese medicines in the treatment of rheumatoid arthritis and the application of short-chain fatty acids were reviewed, so as to provide reference for elucidat-ing the pathogenesis of rheumatoid arthritis, promoting the research and development of related drugs and clarifying the mechanism of action of Chinese medicines.