干细胞巢内的干细胞组成使得十二经脉成为经络系统的主干——十二经脉是决定人体骨骼和骨骼肌进化产生的灵枢

The Twelve Meridians Become the Backbone of the Meridian System Based on the Composition of Stem Cells in Stem Cell Niches—The Twelve Meridians Are the Pivot to Determine the Evolution of Human Skeleton and Skeletal Muscles

摘要: 腧穴是构成经络的基本结构功能单位，彼此离散地分布在细胞组织中。干细胞巢就是腧穴，《黄帝内经》中阐述的人体重要穴位，一般是由众多干细胞巢依一定规律排列组合形成的群落。只有运用干细胞示踪和单细胞测序等足够先进的科学技术，才能逐步验证中医经络学说。《黄帝内经》深刻地揭示了经络是由十二经脉、奇经八脉、十二经别、十二皮部、十二经水和十二经筋、十五络脉以及难以计数的孙络、浮络构成的复杂巨系统。真气(为全能细胞Embryonic stem cell，ES胚胎干细胞表示为 )和元气(为Embryonic germ cell，EG胚胎干细胞划分为七种，表示为 )通常主要在十二经脉和奇经八脉中周流不休，并且敷布全身经络，通过 和 两条胚胎干细胞分化链不断重塑有机体中的各种干细胞巢，使得经络系统具有较强的自我修复和自我进化能力。根据骨骼划分为软骨和硬骨、骨骼肌划分为红肌和白肌等已知的科学事实，本文通过分析十二经脉、十二经筋和十五络脉等中 成体干细胞巢内主要的干细胞成分，指出十二经脉是决定人体骨骼和骨骼肌进化产生的灵枢，初步阐释了十二经脉气血子午流注规律，以及十二经脉与奇经八脉中的六脉(任督二脉除外)有着最为直接的内在联系，使得十二经脉和奇经八脉成为经络系统的主干，有机体中大多数 、 和 多能干细胞巢群落镶嵌在其上。

Abstract: Acupoints are the basic structural and functional units that constitute meridians and are dis-cretely distributed in cellular tissue. Stem cell niches are considered to be acupoints. As de-scribed in the Inner Canon of Yellow Emperor, the important acupoints in the human body are generally acupoint communities formed by numerous stem cell niches that arrange in a certain pattern. The TCM meridian theory can be progressively validated only by using sufficiently ad-vanced scientific techniques, such as stem cell tracing and single cell sequencing. The Inner Ca-non of Yellow Emperor profoundly reveals that the meridians are a complex giant system con-sisting of the twelve meridians, eight extra meridians, branches of the twelve regular meridians, twelve skin areas, waterflow of the twelve meridians, twelve meridian musculatures, fifteen main collaterals and uncountable tertiary collaterals and superficial collaterals. Genuine qi (embryonic stem cells, conventionally expressed as ) and Original qi (embryonic germ cells that can be divided into seven types and expressed as ) usually flow around the twelve meri-dians and the eight extra meridians and are spread throughout the body. They continuously re-shape various stem cell niches in the organism through two embryonic stem cell differentiation chains, and , giving the meridian system a strong capacity for self-healing and self-evolution. Bones are divided into cartilage and skeletal bones and skeletal muscles are divided into red and white muscles. Therefore, we ana-lyze the main stem cell components in adult stem cell niches in the twelve meridians, twelve meridian musculatures, and fifteen main collaterals and propose that the twelve meri-dians are the miraculous pivot that determines the evolution of human bones and skeletal mus-cles. In this paper, the midnight-noon ebb-flow theory in the twelve meridians is preliminarily explained and the twelve meridians has the most direct intrinsic association with the eight extra meridians (except for the Conception and Governor vessels), making the twelve meridians and the eight extra meridians the backbone of the meridian system, on which the majority of pluri-potent stem cell niche communities , and in the organism are embedded.