细胞因子在药物性肝损伤中作用的研究进展

Research Progress on the Role of Cytokines in Drug-Induced Liver Injury

摘要: 药物性肝损伤属于排除性诊断，需要排除病毒、酒精、自身免疫等致病因素的影响。它是最常见的肝损伤形式之一，占所有肝衰竭的一半以上。这也是药品退出市场的最常见原因之一。DILI的诊断存在诸多挑战，迫切需要更好的生物标志物。每种疾病都可能涉及多种细胞因子水平的改变，其中循环细胞因子和趋化因子被认为是组织损伤的可能生物标志物，包括药物性肝损伤(DILI)。促炎细胞因子和抗炎细胞因子的平衡被认为在决定肝损伤恶化或再生的整体平衡中起重要作用，特别是对于具有特殊性质的DILI，细胞因子有望成为诊断药物–肝损伤的生物标志物。故本文对近年来细胞因子在药物性肝损伤中的研究进展进行综述和总结。

Abstract: Drug-induced liver injury is an exclusionary diagnosis, which requires the exclusion of virus, alcohol, autoimmune and other pathogenic factors. It is one of the most common forms of liver damage, ac-counting for more than half of all liver failures. It is also one of the most common reasons drugs are withdrawn from the market. There are many challenges in the diagnosis of DILI, and better bi-omarkers are urgently needed. Each disease may involve changes in the levels of multiple cytokines, of which circulating cytokines and chemokines are considered possible biomarkers of tissue dam-age, including drug-induced liver injury (DILI). The balance of pro-inflammatory cytokines and an-ti-inflammatory cytokines is believed to play an important role in determining the overall balance of deterioration or regeneration of liver injury. Especially for DILI with special properties, cytokines are expected to be biomarkers for the diagnosis of drug-induced liver injury. Therefore, this paper reviews and summaries the research progress of cytokines in drug-induced liver injury in recent years.