非小细胞肺癌中miRNAs的表达水平及作用机制研究进展
The Expression Level and Mechanism of miRNAs in Non-Small Cell Lung Cancer
DOI: 10.12677/ACM.2023.1361254, PDF,    国家自然科学基金支持
作者: 王梅燕*, 吴其繁, 陈国敏：天津商业大学，生物技术与食品科学学院，天津
关键词: miR-34a；miR-106a；miR-130；miR-224；miR-335；非小细胞肺癌；miR-34a； miR-106a； miR-130； miR-224； miR-335； NSCLC
摘要: 如今肺癌在世界范围内的患病率与死亡率增长迅速，对全世界人类的健康造成了严重影响。约有80%的肺癌发病者属于非小细胞肺癌(non-small cell lung cancer, NSCLC)，通常检查出患有NSCLC时已经发展至中期或晚期，这是因为目前NSCLC诊断方式的精确度有待提高以及缺少相关诊断标志物，致使治疗康复难度大大提高，预后复发率高。MicroRNA是一类内源性存在的非编码RNA，长约22个核苷酸，在细胞中可以参与基因转录后调控，其在包括肺癌在内的众多恶性肿瘤中发挥了重要作用。本文选取一些具有代表性的microRNAs，就其在NSCLC中发挥的作用和相关机制以及其在临床应用中的前景展开论述。
Abstract: The morbidity and mortality of lung cancer are increasing rapidly in the world, which has caused a serious impact on human health all over the world. About 80% of lung cancer patients belong to non-small cell lung cancer (NSCLC), and usually diagnosed NSCLC has developed to the middle or late stage, which is because the accuracy of current NSCLC diagnosis needs to be improved and due to the lack of relevant diagnostic markers, resulting in greatly increased difficulty in treatment and rehabilitation, high prognosis and recurrence rate. MicroRNAs are a class of endogenous non- cod-ing RNAs, about 22 nt, which can participate in the regulation of post-transcriptional gene expres-sion in cells and play an important role in many malignant cancers including NSCLC. Some repre-sentative microRNAs are selected to discuss their role and related mechanism in NSCLC and the prospect in clinical application.
文章引用：王梅燕, 吴其繁, 陈国敏. 非小细胞肺癌中miRNAs的表达水平及作用机制研究进展[J]. 临床医学进展, 2023, 13(6): 8959-8965. https://doi.org/10.12677/ACM.2023.1361254

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