脂联素及其基因多态性与糖尿病并发症之间的相关性研究
Study on the Correlation between Adiponectin and Its Gene Polymorphism and Diabetic Complications
DOI: 10.12677/ACM.2023.1361296, PDF,   
作者: 焦怡锋, 巴应贵*:青海大学附属医院肾病科,青海 西宁
关键词: 脂联素糖尿病单核苷酸多态性(SNPs)并发症Adiponectin Diabetes SNPs Complication
摘要: 脂联素(adiponectin)由脂肪细胞分泌,在糖脂代谢、能量代谢、以及心血管系统的生理调节和病理生理中都起着一定作用,与糖尿病、高血压和代谢综合征等疾病密切相关。脂联素在不同种族、年龄、性别的群体中的表达有差异。脂联素具有保护心血管的作用,可预示糖尿病大血管严重程度。本文就脂联素的受体、单核苷酸多态性,脂联素与糖尿病各种并发症的相关性进行了综述。
Abstract: Adiponectin is secreted by adipocytes and plays a role in glycolipid metabolism, energy metabolism, physiological regulation and pathophysiology of the cardiovascular system. It is closely related to diabetes, hypertension and metabolic syndrome. The expression of adiponectin in different ethnic, age and gender groups is different. Adiponectin has a cardiovascular protection effect, which can predict the severity of large vessels in diabetes. This article reviews the receptor of adiponectin, single nucleotide polymorphism, and the correlation between adiponectin and various complica-tions of diabetes.
文章引用:焦怡锋, 巴应贵. 脂联素及其基因多态性与糖尿病并发症之间的相关性研究[J]. 临床医学进展, 2023, 13(6): 9247-9256. https://doi.org/10.12677/ACM.2023.1361296

参考文献

[1] 侯清涛, 李芸, 李舍予. 全球糖尿病疾病负担现状[J]. 中国糖尿病杂志, 2016, 24(1): 92-96.
[2] American Dia-betes A. (2021) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care, 44, S15-S33. [Google Scholar] [CrossRef
[3] Okamoto, Y., Kihara, S., Ouchi, N., et al. (2002) Adi-ponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice. Circulation, 106, 2767-2770. [Google Scholar] [CrossRef
[4] Yamauchi, T., Kamon, J., Waki, H., et al. (2001) The Fat-Derived Hormone Adiponectin Reverses Insulin Resistance Associated with Both Lipoatrophy and Obesity. Nature Medicine, 7, 941-946. [Google Scholar] [CrossRef] [PubMed]
[5] Matsuda, M., Shimomura, I., Sata, M., et al. (2002) Role of Adiponectin in Preventing Vascular Stenosis. The Missing Link of Adipo-Vascular Axis. Journal of Biological Chemistry, 277, 37487-37491. [Google Scholar] [CrossRef
[6] Tanimura, D., Shibata, R., Izawa, H., et al. (2011) Relation of a Common Variant of the Adiponectin Gene to Serum Adiponectin Concentration Andmetabolic Traits in an Aged Japa-nese Population. European Journal of Human Genetics, 19, 262-269. [Google Scholar] [CrossRef] [PubMed]
[7] Schäffler, A., Barth, N., Palitzsch, K.D., et al. (2000) Mutation Analy-sis of the Human Adipocytes Pecicapm-1gene. EurClinInvest, 30, 879-887. [Google Scholar] [CrossRef] [PubMed]
[8] Ceriello, A. (2003) New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy. Diabetes Care, 26, 1589-1596. [Google Scholar] [CrossRef] [PubMed]
[9] 徐丽英, 钟萍, 曹烨民. 脂联素与糖尿病及其并发症的关系研究[J]. 中国医药导报, 2018, 15(28): 29-32.
[10] Kacso, I., Lenghel, A., Bondor, C.L., et al. (2012) Low Plasma Adiponectin Levels Predict Increased Urinary Albumin/Creatinine Ratio in Type 2 Diabetes Patients. International Urol-ogy and Nephrology, 44, 1151-1157. [Google Scholar] [CrossRef] [PubMed]
[11] Saraheimo, M., Forsblom, C., Fagerud, J., et al. (2005) Serum Adiponectin Is Increased in Type 1 Diabetic Patients with Nephropathy. Diabetes Care, 28, 1410-1414. [Google Scholar] [CrossRef] [PubMed]
[12] Kacso, L.I.M., Bondor, C.L. and Kacso, G. (2012) Plasma Adi-ponectin Is Related to the Progression of Kidney Disease in Type 2 Diabetes Patients. Scandinavian Journal of Clinical and Laboratory Investigation, 72, 333-339. [Google Scholar] [CrossRef] [PubMed]
[13] Saraheimo, M., Fosblom, C., Thorn, L., et al. (2008) Serum Adiponectin and Progression of Diabetic Nephropathy in Patients with Type 1 Diabetes. Diabetes Care, 31, 1165-1169. [Google Scholar] [CrossRef] [PubMed]
[14] Prior, S.L., Tang, T.S., Gill, G.V., et al. (2011) Adiponectin, Total Antiox-idantstatus and Urine Albumin Excretion in the Low-Risk “Golden Years” Type 1 Diabetes Mellitus Cohort. Metabolism: Clinical and Experimental, 60, 173-179. [Google Scholar] [CrossRef] [PubMed]
[15] lwal, N., et al. (2004) Genetic Analysis of 22 Candidate Genes for Hypertension in the Japanese Population. Journal of Hypertension, 2, 1119-1126. [Google Scholar] [CrossRef] [PubMed]
[16] Zadal, F., Al-Yahyae, S., Hassan, M.O., Albarwani, S. and Bayoumil, R.A. (2013) Association of Adiponectin Promoter Variants with Traits and Clusters of Metabolic Syn-drome in Arabs: Family-Based Study. Gene, 527, 663-669. [Google Scholar] [CrossRef] [PubMed]
[17] Kishore, S.P., Salam, A., Rodgers, A., et al. (2018) Fixed-Dose Combinations for Hypertension. The Lancet, 392, 819-820. [Google Scholar] [CrossRef
[18] Iacoviello, M., Forleo, C., Sorrentino, S., et al. (2006) α- and β-Adrenergic Receptor Polymorphisms in Hypertensive and Normotensive Offspring. Journal of Cardiovascular Medi-cine, 7, 316-321. [Google Scholar] [CrossRef
[19] Zhang, B., et al. (2011) Association between Single Nucleotide Polymormphisms (SNPs) at the Promoter of Adiponectin Gene and Essential Hypertension in Chinese Kore-an and Han of Yanbian Region. Hereditas (Yi Chuan), 33, 54-59. (In Chinese) [Google Scholar] [CrossRef
[20] Machado, J.S., et al. (2014) Polymorphisms of the Adiponectin Gene in Gestational Hypertension and Pre-Eclampsia. Journal of Human Hypertension, 28, 128-132. [Google Scholar] [CrossRef] [PubMed]
[21] Jiang, B., et al. (2014) Association of Four Insulin Resistance Genes with Type 2 Diabetes Melltus and Hypertension in the Chinese Han Population. Molecular Bioloary Reports, 41, 925-933. [Google Scholar] [CrossRef] [PubMed]
[22] Avery, P.J., Patel, S.K., lbrahim, I.M., Walker, M. and Keavney, B.D. (2011) Common Variation in the Adiponectin Gene Has an Effect on Systolic Blood Pressure. Journal of Hunan Hypertension, 25, 719-724. [Google Scholar] [CrossRef] [PubMed]
[23] Ong, K.L., et al. (2010) Association of Genetic Variants in the Adi-ponectin Gene with Adiponectin Level and Hypertension in Hong Kong Chinese. European Journal of Endocrinolo-gy/European Federation of Endocrine Societies, 163, 251-257. [Google Scholar] [CrossRef
[24] Hara, K., et al. (2002) Genetic Variation in the Gene Encoding Adiponectin Is Associated with an Increased Risk of Type 2 Diabe-tes in the Japanese Population. Diabetes, 51, 536-540. [Google Scholar] [CrossRef] [PubMed]
[25] Bai, Y., et al. (2010) Relationships among Adiponectin Gene Polymorphisms, Proteinuria and Increased Blood Pressure in the Context of Placental Diseases. Hypertension Research, 33, 106-1070. [Google Scholar] [CrossRef] [PubMed]
[26] Weyer, C., Funabashi, T., Tanaka, S., et al. (2001) Hypocdiponeetinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia. The Journal of Clini-cal Endocrinology & Metabolism, 86, 1930-1935. [Google Scholar] [CrossRef] [PubMed]
[27] 郭燕, 蔡艳, 白云霞, 等. 血清脂联素、胰岛素抵抗与代谢综合征的相关性研究[J]. 中国实用医药, 2016, 11(29): 8-10.
[28] Ford, E.S. Giles, W.H. and Dietz, W.H. (2002) Prevalence of the Metabolic Syndrome among US Adults: Findings from the Third National Health and Nutrition Examination Survey. The Journal of the American Medical Association, 287, 356-359. [Google Scholar] [CrossRef] [PubMed]
[29] Reaven, G.M. (2005) The Insulin Resistance Syndrome: Definition and Dietary Approaches to Treatment. Annual Review of Nutrition, 25, 391-406. [Google Scholar] [CrossRef] [PubMed]
[30] Galassi, A., Reynolds, K. and He, J. (2006) Metabolic Syndrome and Risk of Cardiovascular Disease: A Meta-Analysis. The American Journal of Medicine, 119, 812-819. [Google Scholar] [CrossRef] [PubMed]
[31] Gami, A.S., Witt, B.J., Howard, D.E., Erwin, P.J., Gami, L.A., Somers, V.K. and Montori, V.M. (2007) Metabolic Syndrome and Risk of Incident Cardio-Vascular Events and Death: A Systematic Review and Meta-Analysis of Longitudinal Studies. Journal of the American College of Cardiology, 49, 403-414. [Google Scholar] [CrossRef] [PubMed]
[32] Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. and Lodish, H.F. (1995) A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes. Journal of Biological Chemis-try, 270, 26746-26749. [Google Scholar] [CrossRef] [PubMed]
[33] Hu, E., Liang, P. and Spiegelman, B.M. (1996) AdipoQ Is a Novel Adipose-Specific Gene Dysregulated in Obesity. Journal of Biological Chemistry, 271, 10697-10703. [Google Scholar] [CrossRef] [PubMed]
[34] Spranger, J., Kroke, A., Mohlig, M., Bergmann, M.M., Ristow, M., Boeing, H. and Pfeiffer, A.F. (2003) Adiponectin and Prolection against Type 2 Diabetes Mellitus. The Lancet, 361, 226-228. [Google Scholar] [CrossRef
[35] Laughlin, G.A., Barett-Connor, E., May, S. and Langenberg, C. (2007) Association of Acliponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study. Ameri-can Journal of Epidemiology, 165, 164-174. [Google Scholar] [CrossRef] [PubMed]
[36] Iwwashima, Y., Katsuya, T., Ishikawa, K., Ouchi, N., Ohishi, M., Sugimoto, K., Fu, Y., Motone, M., Yamamoto, K., Matsuo, A., Ohashi, K., Kihara, S., Funahashi, T., Rakugi, H., Matsuzawa, Y. and Ogihara, T. (2004) Hypoadiponectinemia Is an Independent Risk Factor for Hypertension. Hyperten-sion, 43, 1318-1323. [Google Scholar] [CrossRef
[37] Hong, S.J., Park, C.G., Seo, H.S., Oh, D. and Ro, Y.M. (2004) Associations among Plasma Adiponectin, Hypertension, Left Ventricular Diastolic Function and Left Ven-tricular Mass Index. Blood Pressure, 13, 236-242. [Google Scholar] [CrossRef] [PubMed]
[38] Zoccali, C., Mallamaci, F., Tripepi, G., Benedetto, F.A., Cutrupi, S., Parlongo, S., Malatino, L.S., Bonanno, G., Seminara, G., Rapisarda, F., Fatuzzo, P., Buemi, M., Nicocia, G., Tanaka, S., Ouchi, N., Kihara, S., Funahashi, T. and Matsuzawa, Y. (2002) Adiponectin, Metabolic Risk Factors and Cardiovas-cular Events among Patients with End-Stage Renaldisease. Journal of the American Society of Nephrology, 13, 134-141. [Google Scholar] [CrossRef
[39] Pischon, T., Girman, C.I., Hotamisligil, G.S., Rifai, N., Hu, F.B. and Rimm, E.B. (2004) Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men. JAMA, 291, 1730-1737. [Google Scholar] [CrossRef] [PubMed]
[40] Golledge, J., Leicht, A., Crowther, R.G., Clancy, P., Spinks, W.L. and Quigley, F. (2007) Association of Obesity and Metabolic Syndrome with the Severity and Outcome of Intermittent Claudication. Journal of Vascular Surgery, 45, 40-46. [Google Scholar] [CrossRef] [PubMed]
[41] Iwashima, Y., Horio, T., Suzuki, Y., Kihara, S., Rakugi, H., Kangawa, K. Funahashi, T., Ogihara, T. and Kawano, Y. (2006) Adi-ponectin and Inflammatory Markers in Peripheral Arterial Occlusive Disease. Atherosclerosis, 188, 384-390. [Google Scholar] [CrossRef] [PubMed]
[42] Robinson, K., Prins, J. and Venkatesh, B. (2011) Clini-cal Review: Adiponectin Biology and Its Role in Inflammation and Critical Illness. Critical Care, 15, Article No. 221. [Google Scholar] [CrossRef] [PubMed]
[43] Yamauchi, T., Kamon, J., Minokoshi, Y., lto, Y., Waki, H., Uchidas, Y.S., Noca, M., Kita, S., Ueki, K., Eto, K., Akanuma, Y., Froguel, P., Foufelle, F., Fere, P., Carling, D., Kimura, S., Nagai, R., Kahn, B.B. and Kadowaki, T. (2002) Adiponectin Stimulates Glucose Utilization and Fatty-Acid Oxidation by Activating AMP-Activated Protein Kinase. Nature Medicine, 8, 1288-1295. [Google Scholar] [CrossRef] [PubMed]
[44] Joshi, M.B., Philippova, M., Ivanov, D., Allenspach, R., Erne, P. and Resink, T.J. (2005) T-Cadherin Protects Endothelial Cells from Oxidative Stress-Induced Apoptosis. FASEB Journal, 19, 1737-1749. [Google Scholar] [CrossRef] [PubMed]
[45] Arita, Y., Kihara, S., Ouchi, N., Maeda, K., Kuriyama, H., Okamoto, Y., Kumada, M., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., Shimomura, I, Muraguchi, M., Ohmoto, Y., Fu-nahashiapos, T. and Matsuzawa, Y. (2002) Adipocyte-Derived Plasma Protein Adiponectinacts as a Platelet-Derived Growth Factor-BB-Binding Protein Andregulates Growth Factor-Induced Common Postreceptor Signal Invascular Smooth Muscle Cell. Circulation, 105, 2893-2898. [Google Scholar] [CrossRef
[46] Trayhurn, P. and Wood, S. (2004) Adipokines: In-flammation and the Pleiotropic Role of White Adipose Tissue. British Journal of Nutrition, 92, 347-355. [Google Scholar] [CrossRef
[47] Lenz, A. and Diamond Jr., F.B. (2008) Obesity: The Hormonal Milieu. Current Opinion in Endocrinology, Diabetes and Obesity, 15, 9-20. [Google Scholar] [CrossRef
[48] Tian, F., Luo, R., Zhao, Z., Wu, Y. and Ban, D.J. (2010) Blockade of the RAS Increases Plasma Adiponectin in Subjects with Metabolic Syndrome and Enhances Differentiation and Adiponectin Expression of Human Preadipocytes. Experimental and Clinical Endocrinology & Diabetes, 118, 258-265. [Google Scholar] [CrossRef] [PubMed]
[49] Chandran, M., Phillips, S.A., Ciaraldi, T. and Henry, R.R. (2003) Adiponectin: More than Just another Fat Cell Hormone? Diabetes Care, 26, 2442-2450. [Google Scholar] [CrossRef] [PubMed]
[50] Díez, J. and Igllesias, P. (2003) The Role of the Novel Adipo-cyte-Dlerived Hormone Adiponectin in Human Disease. European Journal of Endocrinology, 148, 293-300. [Google Scholar] [CrossRef] [PubMed]
[51] Tiikkainen, M., H äkkinen, A.-M., Korsheninnikova, E., Nyman, T., Mäkimattila, S. and Yki-Järvinen, H. (2004) Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insu-lin Resistance, Insulin Clearance, and Gene Expression Inadipose Tissuc in Patients with Type 2 Diabetes. Diabetes, 53, 2169-2176. [Google Scholar] [CrossRef] [PubMed]
[52] Miyazaki, Y., Mahankali, A., Wajcberg, E., Bajaj, M., Mandarino, L.J. and DeFronzo, R.A. (2004) Effect of Pioglitazone on Circulating Adipocytokine Levels and Insulin Sensitivity in Type 2 Diabetic Patients. The Journal of Clinical Endocrinology & Metabolism, 89, 4312-4319. [Google Scholar] [CrossRef] [PubMed]
[53] Shinmura, K., Tamaki, K., Saito, K., Nakano, Y., Tobe, T. and Bolli, R. (2007) Cardioprotective Effects of Shor-Term Caloric Restriction Are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase. Circulation, 116, 2809-2817. [Google Scholar] [CrossRef
[54] Gómez-Arbeláez, D. Lahera, V., Oubiña, P., Valero-Muñoz, M., de Las Heras, N., Rodriguez, Y., García, R.G., Camacho, P.A. and López-Jaramillo, P. (2013) Aged Garlic Extract Improves Adiponectinlevels in Subjects with Metabolic Syndrome: A Double-Blind, Placebo-Controlled, Randomized, Crossover Study. Mediators of Inflammation, 2013, Article ID: 285795. [Google Scholar] [CrossRef] [PubMed]
[55] Decleves, A.E., Mathew, A.V., Cunard, R., et al. (2011) AMPK Medi-ates the Initiation of Kidney Disease Induced by a High-Fat Diet. Journal of the American Society of Nephrology: JASN, 22, 1846-1855. [Google Scholar] [CrossRef
[56] Shibata, R., Ouch, N. and Murohara, T. (2009) Adiponectin and Cardiovascular Disease. Circulation Journal, 73, 618-614. [Google Scholar] [CrossRef
[57] Mallamaci, F., Zoccali, C., Cuzzola, F., et al. (2002) Adiponectin in Essential Hypertension. Journal of Nephrology, 15, 507-511.
[58] Adamczak, M., Czerwienska, B., Chudek, J. and Wiecek, A. (2007) Renal Extraction of Circulating Adi-ponectin in Patients with Renovascular Hypertension. Acta Physiologica Hungarica, 94, 143-148. [Google Scholar] [CrossRef
[59] Lwashima, Y., Horio, T., Kumada, M., et al. (2006) Adi-ponectin and Renal Function and Implication as a Risk of Cardiovascular Disease. The American Journal of Cardiology, 98, 1603-1608. [Google Scholar] [CrossRef] [PubMed]
[60] Ignacy, W., Chudiek, J., Adamczak, M., et al. (2005) Recipro-cal Association of Plasma Adiponectin and Serum C-Reactive Protein Concentration in Haemodialysis Patients with End-Stage Kidney Disease: A Follow-Up Study. Nephron Clinical Practice, 101, c18-c24. [Google Scholar] [CrossRef] [PubMed]
[61] Marchlewska, A., Stenvinkel, P., Lindholm, B., et al. (2004) Reduced Gene Expression of Adiponectin in Fat Tissue from Patients with End-Stage Renal Disease. Kidney International, 66, 46-50. [Google Scholar] [CrossRef] [PubMed]
[62] Shen, Y.Y., Charlesworth, J.A., Kelly, J.J., Loi, K.W. and Peake, P.W. (2007) Up-Regulation of Adiponectin, Its Isoforms and Receptors in End-Stage Kidney Disease. Nephrolo-gy, Dialysis, Transplantation, 22, 171-178. [Google Scholar] [CrossRef] [PubMed]
[63] Tsigalou, C., Chalikias, C., Kantartzi, K., et al. (2013) Differential Effect of Baseline Adiponectin on All-Cause Mortality in Hemodialysis Patients Depending on Initial Body Mass Index. Long-Term Follow-Up Data of 4.5 Years. Journal of Renal Nutrition, 23, 45-56. [Google Scholar] [CrossRef] [PubMed]
[64] Ldorn, T., Hormum, M., Bjere, M., et al. (2012) Plasma Adiponectin before and after Kidney Transplantation. Transplant International, 25, 1194-1203. [Google Scholar] [CrossRef] [PubMed]