脓毒症心肌病发病危险因素Meta分析
Meta-Analysis of Risk Factors for Septic Cardiomyopathy
DOI: 10.12677/ACM.2023.1361305, PDF,    科研立项经费支持
作者: 刘松伍*：青岛大学第十一临床学院，山东 青岛；临沂市人民医院心血管内科，山东 临沂；刘瑞金, 侯建同, 郭德群, 魏延津#：临沂市人民医院心血管内科，山东 临沂
关键词: 脓毒症心肌病；危险因素；病例对照；Meta分析；Septic Cardiomyopathy； Risk Factors； Case-Control； Meta-Analysis
摘要: 目的：系统评价导致脓毒症心肌病的危险因素为其预防提供理论依据。方法：计算机检索中国知网、维普、万方、CBM、Pubmed、Embase、Web of Science、Cochrane Library等数据库，经文献筛选、质量评价和效应量提取后采用Stata14.0软件对数据进行分析。结果：最终纳入21篇文献(2022年8月之前)累积脓毒症患者5258例，发生脓毒症心肌病1960例，Meta分析结果显示NT-proBNP [OR = 2.48, 95% CI (1.71, 3.56)]、PCT [OR = 1.17, 95% CI (1.09, 1.26)]、APACHEII评分[OR = 1.89, 95% CI (1.44, 1.48)]、糖尿病[OR = 2.0, 95% CI (1.61, 2.48)]、年龄[OR = 1.05, 95% CI (1.03, 1.08)]、低MAP [OR = 0.5, 95% CI (0.41, 0.61)]、SOFA评分[OR = 1.46, 95% CI (1.17, 2.21)]、肌钙蛋白I [OR = 1.04, 95% CI (1.02, 1.06)]与脓毒症相关心肌病发病相关。结论：NT-proBNP、APACHEII评分、PCT、糖尿病、年龄、CK-MB、SOFA评分、肌钙蛋白I、低MAP是脓毒症相关心肌病发病的危险因素。
Abstract: Objective: A systematic review of risk factors leading to septic cardiomyopathy provides a theoreti-cal basis for its prevention. Methods: CNKI, VIP, Wanfang, CBM, Pubmed, Embase, Web of Science, Cochrane Library and other databases were searched by computer. After literature screening, qual-ity evaluation and effect size extraction, the data were analyzed using Stata14.0 software. Results: 21 literatures (Before August 2022) were finally included, with a total of 5258 cases of sepsis pa-tients and 1960 cases of septic cardiomyopathy. Meta-analysis showed that NT-proBNP [OR = 2.48, 95% CI (1.71, 3.56)] , PCT [OR = 1.17, 95% CI (1.09, 1.26)], APACHEII score [OR = 1.89, 95% CI (1.44, 1.48)], diabetes [OR = 2.0, 95% CI (1.61, 2.48)], Age [OR = 1.05, 95% CI (1.03, 1.08)], low mean ar-terial pressure [OR = 0.5, 95% CI (0.41, 0.61)], SOFA score [OR = 1.46, 95% CI (1.17, 2.21)], tro-ponin I [OR= 1.04, 95% CI (1.02, 1.06)] were associated with the pathogenesis of septic cardiomyo-pathy. Conclusion: NT-proBNP, APACHEII score, PCT, diabetes mellitus, age, CK-MB, SOFA score, tro-ponin I, lower MAP are risk factors for septic cardiomyopathy.
文章引用：刘松伍, 刘瑞金, 侯建同, 郭德群, 魏延津. 脓毒症心肌病发病危险因素Meta分析[J]. 临床医学进展, 2023, 13(6): 9325-9335. https://doi.org/10.12677/ACM.2023.1361305

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