LncRNA H19在子宫内膜异位症中的研究进展
Research Progress of LncRNA H19 in Endometriosis
DOI: 10.12677/ACM.2023.1361308, PDF,   
作者: 曾晓艳, 万晓慧*：新疆医科大学第一附属医院，新疆 乌鲁木齐
关键词: LncRNA H19；子宫内膜异位症；发病机制；IncRNA H19； Endometriosis； Pathogenesis
摘要: 子宫内膜异位症(EMs)是一种慢性疾病，其特点是激素反应性是子宫内膜样组织存在子宫体以外的部位。子宫内膜组织的增殖和新生血管形成是子宫内膜异位症发生发展的重要因素。长非编码RNA (Long Non Coding RNAs, LncRNAs)是一组含有200多个核苷酸的非编码单链RNA，参与细胞增殖、分化、染色体重塑、表观遗传调控、转录和转录后修饰等生物学过程。印迹长非编码RNA H19 (LncRNA H19)可能通过调节细胞增殖和凋亡、侵袭、迁移等参与子宫内膜异位症的发病，LncRNA H19表观遗传异常在其发病机制中起着重要作用。本研究旨在探讨LncRNA H19基因的表达及H19-DMR调控区差异甲基化区域(DMR)的表观遗传学改变及LncRNA H19基因与胰岛素样生长因子1 (IGF1)、α-平滑肌肌动蛋白(ACTA2)等在子宫内膜异位症的信号通路调节作用，主要包括遗传表观学、细胞的增殖、凋亡、侵袭、迁移、复发等内容，为临床治疗子宫内膜异位症提供进一步的理论支持。
Abstract: Endometriosis, as chronic estrogen-dependent disease, is defined by the presence of endometri-al-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are critical factors in development of endometriosis. Long non coding RNAs (LncRNAs) are a group of non cod-ing single-stranded RNAs with more than 200 nucleotides that participate in biological processes, including cell proliferation, differentiation, chromosome remodeling, epigenetic regulation, tran-scription, and posttranscriptional modification. Imprinted long non coding RNA H19 (LncRNA H19) may be involved in the pathogenesis of endometriosis by regulating cell proliferation and apoptosis, invasion, and migration, and epigenetic abnormalities in LncRNA H19 play an important role in its pathogenesis. The aim of this study was to investigate the expression of LncRNA H19 gene and epi-genetic alterations in the differentially methylated region (DMR) of the H19-DMR regulatory region and the role of LncRNA H19 gene and insulin-like growth factor 1 (IGF1) and actin alpha 2 (ACTA2) in the regulation of signaling pathways in endometriosis, mainly including genetic epigenetics, cell proliferation, apoptosis, invasion, migration, and recurrence, in order to provide further theoretical support for the clinical treatment of endometriosis.
文章引用：曾晓艳, 万晓慧. LncRNA H19在子宫内膜异位症中的研究进展[J]. 临床医学进展, 2023, 13(6): 9350-9355. https://doi.org/10.12677/ACM.2023.1361308

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