基于“肾藏精”理论探讨外泌体与阿尔茨海默症的相关性
On the Exploration of the Relationship between Exosomes and Alzheimer’s Disease Based on the Theory of “Kidney Stores the Essence”
DOI: 10.12677/TCM.2023.126187, PDF,    国家自然科学基金支持
作者: 张丽敏, 苏 进, 李 文*：贵州中医药大学基础医学院，贵州 贵阳
关键词: 肾藏精；外泌体；阿尔茨海默症；补肾益精；Kidney Stores the Essence； Exosomes； Alzheimer’s Disease； Reinforcing Kidney for Supplementing Essence
摘要: 阿尔茨海默症(Alzheimer’s disease, AD)是一种神经退行性疾病，常伴有认知、记忆、语言等障碍，是老年人常见的痴呆形式。外泌体是一种纳米级的细胞外囊泡，广泛存在于血液、唾液、尿液、脑脊液等体液中，有独特的生物学特性，可以穿过血脑屏障，帮助诊断和治疗包括AD在内的神经系统疾病。AD主要病位在脑，因肾精亏虚，不能充养脑髓，髓海渐空，进而元神失养所致，临床中用补肾益精法治疗，肾精充足则脑髓得充，元神有所养，进而能有效缓解临床症状。故本文对“肾藏精”理论、外泌体、阿尔茨海默症，以及三者之间的关系进行了阐述，以期找到治疗AD新的思路与方向。
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease often associated with cognitive, memory, and language impairments, and is a common form of dementia in the elderly. Exosomes are nano-sized extracellular vesicles that exist widely in blood, saliva, urine, cerebrospinal fluid and other body fluids. They have unique biological characteristics and can cross the blood-brain barrier, help diagnose and treat neurological disorder, including AD. The main location of AD is in the brain. Due to the deficiency of kidney essence, the brain marrow cannot be nourished, and the marrow sea becomes gradually empty, resulting in the loss of vitality. In clinic, the method of tonifying the kidney and replenishing the essence is used to treat AD. The brain and marrow are replenished when the kidney essence is sufficient, and then the nourishment of the spirit can effectively alleviate the clinical symptoms. Therefore, this article expounds the theory of “Kidney stores the essence”, exosomes, Alzheimer’s disease and the relationship among them, in order to find a new idea and direction for the treatment of AD.
文章引用：张丽敏, 苏进, 李文. 基于“肾藏精”理论探讨外泌体与阿尔茨海默症的相关性[J]. 中医学, 2023, 12(6): 1249-1257. https://doi.org/10.12677/TCM.2023.126187

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