脂肪因子与妇科疾病相关性
The Correlation between Adipokines and Gynecological Diseases
DOI: 10.12677/ACM.2023.1361317, PDF,   
作者: 祁 璘：青海大学研究生院，青海 西宁 ；迪 吉*：青海大学附属医院肿瘤内科，青海 西宁
关键词: 脂肪因子；妇科领域；Adipokine； Gynecological Field
摘要: 人体内的脂肪组织是一个内分泌器官，它即可以储存能量，也可以分泌多种炎症介质和细胞因子。脂肪组织分泌的细胞因子包括：肿瘤坏死因子-α (TNF-α)、白介素-6 (IL-6)、网膜素(Omentin)、瘦素(Leptin)、内脂素(Visfatin)等。各种研究表明脂肪细胞因子与肥胖、恶性肿瘤、糖尿病、心脑血管疾病、多囊卵巢综合征、炎症性疾病等多种疾病的发生发展及预后有关。所以本文就脂肪因子在妇科领域中的研究进展作一综述。
Abstract: Adipose tissue in the human body is an endocrine organ that can store energy and secrete various inflammatory mediators and cytokines. The cytokines secreted by adipose tissue include tumor ne-crosis factor-α (TNF-α), Interleukin-6 (IL-6), omentin, leptin, visfatin, etc. Various studies have shown that adipocytokines are related to the occurrence, development and prognosis of obesity, malignant tumors, diabetes, cardiovascular and cerebrovascular diseases, polycystic ovary syn-drome, inflammatory diseases and other diseases. So this article reviews the research progress of adipokines in the field of gynecology.
文章引用：祁璘, 迪吉. 脂肪因子与妇科疾病相关性[J]. 临床医学进展, 2023, 13(6): 9410-9416. https://doi.org/10.12677/ACM.2023.1361317

参考文献

[1] Yang, R.Z., et al. (2006) Identification of Omentin as a Novel Depot-Specific Adipokine in Human Adipose Tissue: Possible Role in Modulating Insulin Action. American Journal of Physiology. Endocrinology and Metabolism, 290, E1253-E1261. [Google Scholar] [CrossRef] [PubMed]
[2] 周吉银, 张祚, 刘远志, 李和教. 新型脂肪因子网膜素-1抗炎作用的研究进展[J]. 生理科学进展, 2018, 49(2): 149-152.
[3] de Souza Batista, C.M., et al. (2007) Omentin Plasma Levels and Gene Expression Are Decreased in Obesity. Diabetes, 56, 1655-1661. [Google Scholar] [CrossRef] [PubMed]
[4] Zhao, A., et al. (2022) Omentin-1: A Newly Discovered Warrior against Metabolic Related Diseases. Expert Opinion on Therapeutic Targets, 26, 275-289. [Google Scholar] [CrossRef] [PubMed]
[5] Watanabe, T., Watanabe-Kominato, K., Takahashi, Y., Koji-ma, M. and Watanabe, R. (2017) Adipose Tissue-Derived Omentin-1 Function and Regulation. Comprehensive Physiol-ogy, 7, 765-781. [Google Scholar] [CrossRef] [PubMed]
[6] Zhang, Y., et al. (1994) Positional Cloning of the Mouse Obese Gene and Its Human Homologue. Nature, 372, 425-432. [Google Scholar] [CrossRef] [PubMed]
[7] Angelucci, A., Clementi, L. and Alesse, E. (2020) Leptin in Tumor Micro-environment. Advances in Experimental Medicine and Biology, 1259, 89-112. [Google Scholar] [CrossRef] [PubMed]
[8] Samal, B., et al. (1994) Cloning and Characterization of the cDNA Encoding a Novel Human Pre-B-Cell Colony- Enhancing Factor. Molecular and Cellular Biology, 14, 1431-1437. [Google Scholar] [CrossRef] [PubMed]
[9] Rongvaux, A., et al. (2002) Pre-B-Cell Colony-Enhancing Factor, Whose Expression Is Up-Regulated in Activated Lymphocytes, Is a Nicotinamide Phosphoribosyltransferase, a Cytosolic Enzyme Involved in NAD Biosynthesis. European Journal of Immunology, 32, 3225-3234. [Google Scholar] [CrossRef] 
[10] Fukuhara, A., et al. (2005) Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin. Science (New York, N.Y.), 307, 426-430. [Google Scholar] [CrossRef] [PubMed]
[11] Luk, T., Malam, Z. and Marshall, J.C. (2008) Pre-B Cell Colony-Enhancing Factor (PBEF)/Visfatin: A Novel Mediator of Innate Immunity. Journal of Leukocyte Biology, 83, 804-816. [Google Scholar] [CrossRef] [PubMed]
[12] Sun, B.L., et al. (2020) Role of Secreted Extracellular Nicotina-mide Phosphoribosyltransferase (eNAMPT) in Prostate Cancer Progression: Novel Biomarker and Therapeutic Target. EBioMedicine, 61, Article ID: 103059. [Google Scholar] [CrossRef] [PubMed]
[13] Revollo, J.R., et al. (2007) Nampt/PBEF/Visfatin Regulates In-sulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme. Cell Metabolism, 6, 363-375. [Google Scholar] [CrossRef] [PubMed]
[14] Kralisch, S., et al. (2005) Interleukin-6 Is a Negative Regulator of Visfatin Gene Expression in 3T3-L1 Adipocytes. American Journal of Physiology. Endocrinology and Metabolism, 289, E586-E590. [Google Scholar] [CrossRef] [PubMed]
[15] Zhai, Y. and Pang, Y. (2022) Systemic and Ovarian Inflammation in Women with Polycystic Ovary Syndrome. Journal of Reproductive Immunology, 151, Article ID: 103628. [Google Scholar] [CrossRef] [PubMed]
[16] 刘聪, 李丽玮, 韩研, 董丽霞, 殷秀荣. 脂肪因子omentin-1与多囊卵巢综合征的相关性[J]. 生殖医学杂志, 2018, 27(11): 1091-1095.
[17] Zheng, S.H., Du, D.F. and Li, X.L. (2017) Leptin Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and a Meta-Analysis. Reproductive Sciences (Thousand Oaks, Calif.), 24, 656-670. [Google Scholar] [CrossRef] [PubMed]
[18] Micić, D., et al. (1997) Leptin Levels and Insulin Sensitivity in Obese and Non-Obese Patients with Polycystic Ovary Syndrome. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology, 11, 315-320. [Google Scholar] [CrossRef] [PubMed]
[19] Erturk, E., et al. (2004) Serum Leptin Levels Correlate with Obesity Parameters But Not with Hyperinsulinism in Women with Polycystic Ovary Syndrome. Fertility and Sterility, 82, 1364-1368. [Google Scholar] [CrossRef] [PubMed]
[20] Pehlivanov, B. and Mitkov, M. (2009) Serum Leptin Levels Correlate with Clinical and Biochemical Indices of Insulin Resistance in Women with Polycystic Ovary Syndrome. The European Journal of Contraception and Reproductive Health Care: The Official Journal of the European Society of Contraception, 14, 153-159. [Google Scholar] [CrossRef] [PubMed]
[21] Nasrat, H., Patra, S.K., Goswami, B., Jain, A. and Raghunandan, C. (2016) Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS. Indian Journal of Clinical Biochemistry: IJCB, 31, 104-107. [Google Scholar] [CrossRef] [PubMed]
[22] Garruti, G., et al. (2014) Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome. BioMed Research Inter-national, 2014, Article ID: 980429. [Google Scholar] [CrossRef] [PubMed]
[23] Abdul-Maksoud, R.S., Zidan, H.E., Saleh, H.S. and Amer, S.A. (2020) Visfatin and SREBP-1c mRNA Expressions and Serum Levels among Egyptian Women with Polycystic Ovary Syn-drome. Genetic Testing and Molecular Biomarkers, 24, 409-419. [Google Scholar] [CrossRef] [PubMed]
[24] 刘聪, 殷秀荣, 李丽玮, 董丽霞. 血浆内脂素与多囊卵巢综合征患者糖脂代谢的相关性研究[J]. 生殖医学杂志, 2018, 27(6): 579-581.
[25] Zhang, J., Zhou, L., Tang, L. and Xu, L. (2014) Plasma Visfatin Levels and mRNA Expres-sion of Visfatin in Peripheral Blood Mononuclear Cells and Peripheral Blood Monocyte-Derived Macrophages from Normal Weight Females with Polycystic Ovary Syndrome. Experimental and Therapeutic Medicine, 7, 1215-1220. [Google Scholar] [CrossRef] [PubMed]
[26] 张力, 梁朝朝, 张礼刚, 等. 血清网膜素-1与前列腺癌的相关性研究[J]. 现代泌尿生殖肿瘤杂志, 2016, 8(3): 150-154.
[27] Olea-Flores, M., et al. (2020) New Actors Driving the Epi-thelial-Mesenchymal Transition in Cancer: The Role of Leptin. Biomolecules, 10, Article No. 1676. [Google Scholar] [CrossRef] [PubMed]
[28] Ray, A., et al. (2018) Gynaecological Cancers and Leptin: A Focus on the Endometrium and Ovary. Facts, Views and Vision in ObGyn, 10, 5-18.
[29] 白娥, 王丽, 李海军, 韩苏夏. 内脂素-Nampt轴在卵巢上皮癌进展中的作用[J]. 西安交通大学学报(医学版), 2022, 43(2): 228-233.
[30] Pan, H.Y., Guo, L. and Li, Q. (2010) Changes of Serum Omentin-1 Levels in Normal Subjects and in Patients with Impaired Glucose Regulation and with Newly Diagnosed and Untreated Type 2 Diabetes. Diabetes Research and Clinical Practice, 88, 29-33. [Google Scholar] [CrossRef] [PubMed]
[31] Herder, C., et al. (2015) Adiponectin May Mediate the Association between Omentin, Circulating Lipids and Insulin Sensitivity: Results from the KORA F4 Study. European Journal of Endocrinology, 172, 423-432. [Google Scholar] [CrossRef] 
[32] Liu, R., Wang, X. and Bu, P. (2011) Omentin-1 Is Associated with Ca-rotid Atherosclerosis in Patients with Metabolic Syndrome. Diabetes Research and Clinical Practice, 93, 21-25. [Google Scholar] [CrossRef] [PubMed]
[33] Sperling, M., et al. (2016) Concentrations of Omentin and Vaspin versus Insulin Resistance in Obese Individuals. Biomedicine and Pharmacotherapy, 83, 542-547. [Google Scholar] [CrossRef] [PubMed]
[34] Li, M., et al. (2019) Spontaneous Formation of Tumorigenic Hybrids between Human Omental Adipose-Derived Stromal Cells and Endometrial Cancer Cells Increased Motility and Heterogeneity of Cancer Cells. Cell Cycle (Georgetown, Tex.), 18, 320-332. [Google Scholar] [CrossRef] [PubMed]
[35] Fader, A.N., Arriba, L.N., Frasure, H.E. and von Gruenigen, V.E. (2009) Endometrial Cancer and Obesity: Epidemiology, Biomarkers, Prevention and Survivorship. Gynecologic Oncology, 114, 121-127. [Google Scholar] [CrossRef] [PubMed]
[36] Pavelić, J., Radaković, B. and Pavelić, K. (2007) Insulin-Like Growth Factor 2 and Its Receptors (IGF 1R and IGF 2R/Mannose 6-Phosphate) in Endometrial Adenocarcinoma. Gy-necologic Oncology, 105, 727-735. [Google Scholar] [CrossRef] [PubMed]

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