富血小板血浆局部注射治疗肱骨外上髁炎的疗效观察

Efficacy Observation of Local Injection of Platelet-Rich Plasma in the Treatment of Ex-ternal Humeral Epicondylitis

摘要: 目前国内外关于PRP治疗肱骨外上髁炎的临床研究报道较多，观点不一，大部分研究认为PRP疗法对于肱骨外上髁炎患者有效。因此此次课题任务将完成富血小板血浆局部注射治疗肱骨外上髁炎的疗效观察，通过对治疗结果的分析，探讨该方法对肱骨外上髁炎的作用机理，从而更好地指导我们对于肱骨外上髁炎的临床治疗。于治疗前、治疗后一周及治疗后1月、3月及6月对患者进行电话回访或门诊随诊。采用疼痛视觉模拟评分(visual analogue scale, VAS)、Mayo肘关节功能评分(Mayo elbow performance score, MEPS)和肩臂手残障(disabilities of the arm, shoulder and hand, DASH)评分评价临床结果。结果表明：局部注射自体PRP和糖皮质激素治疗肱骨外上髁炎早期均能缓解疼痛，改善肘关节功能，但其作用时间治疗周期较长，短期效果不如糖皮质激素治疗，而糖皮质激素治疗后期逐渐失效，PRP治疗效果逐渐提升。

Abstract: There are many clinical studies on PRP for the treatment of external humeral epicondylitis at home and abroad with different opinions, most of which concluded that PRP therapy is effective for pa-tients with external humeral epicondylitis. Therefore, this task will complete the observation of the efficacy of platelet-rich plasma local injection for the treatment of external humeral epicondylitis, and explore the mechanism of the method on external humeral epicondylitis through the analysis of the treatment results, so as to better guide our clinical treatment of external humeral epicondyli-tis. Patients were followed up by telephone before, one week after treatment, and one month, three months and six months after treatment. The visual analogue scale (VAS), the Mayo elbow perfor-mance score (MEPS) and the disability of the arm, shoulder and hand (DASH) scores were used to evaluate clinical outcomes. The clinical outcomes were evaluated. The results showed that both lo-cal injection of autologous PRP and glucocorticoids could relieve pain and improve the function of the elbow joint in the early stage of external humeral epicondylitis, but their duration of action was longer than that of glucocorticoid treatment, and the short-term effect was inferior to that of gluco-corticoid treatment, while glucocorticoid treatment gradually failed in the later stage and the effect of PRP treatment gradually improved.