间充质干细胞来源的外泌体在低氧条件下的作用与机制研究进展
Research Progress on the Role and Mechanism of Exosomes Derived from Mesenchymal Stem Cells under Hypoxic Con-ditions
摘要: 背景：外泌体无细胞结构、分子量小、免疫原性比亲本细胞小且更容易通过毛细血管及血脑屏障，用外泌体代替间充质干细胞移植越来越成为一种更加高效、安全的新型治疗手段。目的：对低氧条件下间充质干细胞来源的外泌体在疾病发生发展中的作用与机制的研究进展进行概述，为低氧相关疾病的研究和治疗提供新思路。方法：应用计算机检索自建库至2023-05 PubMed、Web of Science、中国知网和中国生物医学文献数据库发表的相关文献，检索关键词为“间充质干细胞，外泌体，低氧，心脑血管疾病，癌症，肿瘤，炎症”“mesenchymal stem cell, exosomes, hypoxia, cardiovascular and cerebrovascular diseases, cancer, tumour, inflammation”。结果与结论：处于疾病本身低氧环境中的正常间充质干细胞外泌体和经过低氧诱导的间充质干细胞外泌体通过被靶细胞摄取或直接向其传递多种调控因子实现对多种疾病的干预与治疗。
Abstract: BACKGROUND: Exosomes have no cell structure, small molecular weight, smaller immunogenicity than their parent cells and are easier to pass through the capillary and blood-brain barrier. Using exosomes instead of mesenchymal stem cells transplantation has increasingly become a more effi-cient and safe new treatment method. OBJECTIVE: To summarize the role and mechanism of exo-somes derived from mesenchymal stem cells in the occurrence and development of hypoxic diseas-es, and provide new ideas for the research and treatment of hypoxic-related diseases. METHODS: Relevant literature published by PubMed, Web of Science, CNKI and China Biomedical Literature Database from the establishment of the database to 2022-12. Search terms were “mesenchymal stem cell, exosomes, hypoxia, cardiovascular and cerebrovascular diseases, cancer, tumour, in-flammation” in English and Chinese, respectively. RESULTS AND CONCLUSION: Normal mesenchy-mal stem cell exosomes in the hypoxic environment of the disease itself and Hypoxia-induced exo-somes of mesenchymal stem cells can intervene and treat many diseases by being ingested by tar-get cells or directly transmitting a variety of regulatory factors to them.
文章引用：常森昊, 张建安, 贾云飞, 赵万花, 田雨, 李文华. 间充质干细胞来源的外泌体在低氧条件下的作用与机制研究进展[J]. 临床医学进展, 2023, 13(6): 9577-9585. https://doi.org/10.12677/ACM.2023.1361340

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