Caspase-1、Cdk5、NLRP3与特发性炎性肌病的相关性
Correlation between Caspase-1, Cdk5, NLRP3 and Idiopathic Inflammatory Myopathy
DOI: 10.12677/ACM.2023.1361343, PDF,   
作者: 刘三兄：青海大学研究生院，青海 西宁；柴克霞：青海大学附属医院 风湿免疫科，青海 西宁
关键词: Caspase-1；Cdk5；NLRP3；细胞凋亡；特发性炎性肌病 ；Caspase-1； Cdk5； NLRP3； Apoptosis； Idiopathic Inflammatory Myopathy
摘要: 特发性炎性肌病(IIM)是以骨骼肌受累为突出表现的一组自身免疫性疾病，其发病与多个细胞因子有关，目前，关于IIM的病因及发病机制尚不完全清楚，研究认为其主要发病机制由免疫机制与非免疫机制两部分共同参与。目前关于其机制的主要研究热点有固有免疫、炎性反应、基因相关、微血管病变、凋亡、自噬、焦亡等多个方面。对那些病变早期的不典型皮肌炎患者初期临床表现不严重又或者没有特异性，实验室的项目检查也没有明显异常，因此对诊断疾病和疾病的鉴别诊断都增加了不少的困难。所以，进一步探究IIM的发病机制有着非常重要的意义。Caspase-1、Cdk5、NLRP3是细胞凋亡过程中的参与因子，且与多种疾病密切相关，如自身免疫性疾病、肿瘤、病毒感染及纤维化等。本文就Caspase-1、Cdk5、NLRP3与特发性炎性肌病的关系作一综述。
Abstract: Idiopathic inflammatory myopathy (IIM) is a group of autoimmune diseases characterized by skel-etal muscle involvement, and its pathogenesis is related to many cytokines. At present, the etiology and pathogenesis of IIM are not completely clear, and it is considered that its main pathogenesis is composed of immune mechanism and non-immune mechanism. At present, the main research fo-cuses on its mechanism are innate immunity, inflammatory reaction, gene correlation, microvascu-lar disease, apoptosis, autophagy, focal death and so on. For those patients with atypical derma-tomyositis in the early stage of the disease, the initial clinical manifestations are not serious or spe-cific, and there is no obvious abnormality in laboratory examination, so it is more difficult to diag-nose diseases and differential diagnosis of diseases. Therefore, it is of great significance to further explore the pathogenesis of IIM. Caspase-1, Cdk5 and NLRP3 are involved factors in the process of apoptosis, and are closely related to many diseases, such as autoimmune diseases, tumors, viral in-fections and fibrosis. This article reviews the relationship between Caspase-1, Cdk5, NLRP3 and id-iopathic inflammatory myopathy.
文章引用：刘三兄, 柴克霞. Caspase-1、Cdk5、NLRP3与特发性炎性肌病的相关性[J]. 临床医学进展, 2023, 13(6): 9599-9604. https://doi.org/10.12677/ACM.2023.1361343

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