FGF23与脂质代谢和胰岛素抵抗的关系
The Relationship between FGF23 and Lipid Metabolism and Insulin Resistance
DOI: 10.12677/ACM.2023.1361344, PDF,    科研立项经费支持
作者: 张梓航：西安医学院研究生院，陕西 西安；李雪萍*, 李 科：西安市常见老龄疾病防治重点实验室、慢病防治研究与转化中心、基础与转化医学研究所，陕西 西安；宋 梅, 周 韵, 马建梅：西安医学院临床医学院，陕西 西安；郭 剑, 闫娜娜：陕西省人民医院，陕西 西安
关键词: 成纤维细胞生长因子23；脂质代谢；胰岛素抵抗；抵抗素；Fibroblast Growth Factor 23； Lipid Metabolism； Insulin Resistance； Resistin
摘要: 成纤维细胞生长因子23是一个具有内分泌功能的细胞因子，在钙磷代谢调节中发挥着不容忽视的作用；它来自于多种组织和器官，在糖尿病及其并发症中被发现表达明显升高，有助于糖尿病及其并发症发生、发展的进一步评估。近年来不少研究发现FGF23还与脂质代谢和胰岛素抵抗存在密切联系；被认为可以帮助我们为代谢性相关疾病提供新的治疗思路，以期降低疾病发生率。但FGF23的作用机制并未完全阐明，未来还需更多研究证明FGF23与脂质代谢及胰岛素抵抗的相关性。
Abstract: Fibroblast growth factor 23 is an endocrine cytokinine that plays an important role in the regula-tion of calcium and phosphorus metabolism. It comes from a variety of tissues and organs, and its expression has been significantly increased in diabetes and its complications, which is conducive to the further evaluation of the occurrence and development of diabetes and its complications. In re-cent years, many studies have found that FGF23 is also closely related to lipid metabolism and insu-lin resistance; it is believed to help us provide new treatment ideas for metabolic-related diseases with a view to reducing the incidence of diseases. However, the mechanism of action of FGF23 has not been fully clarified, and more research is needed in the future to prove the correlation between FGF23 with lipid metabolism and insulin resistance.
文章引用：张梓航, 李雪萍, 宋梅, 郭剑, 闫娜娜, 周韵, 马建梅, 李科. FGF23与脂质代谢和胰岛素抵抗的关系[J]. 临床医学进展, 2023, 13(6): 9605-9610. https://doi.org/10.12677/ACM.2023.1361344

参考文献

[1] 曾越茜, 游利. 成纤维细胞生长因子19亚家族在骨骼肌中的作用[J]. 中华骨质疏松和骨矿盐疾病杂志, 2020, 13(4): 362-366.
[2] Izaguirre, M., Gil, M.J., Monreal, I., et al. (2017) The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes. Current Diabetes Reports, 17, Article No. 43. [Google Scholar] [CrossRef] [PubMed]
[3] Faul, C., Amaral, A.P., Oskouei, B., et al. (2011) FGF23 Induces Left Ventricular Hypertrophy. Journal of Clinical Investigation, 121, 4393-4408. [Google Scholar] [CrossRef] 
[4] 闫奇奇, 郝丽, 张森. 慢性肾脏病患者血清FGF23水平与钙磷代谢及临床相关性[J]. 安徽医科大学学报, 2019, 54(5): 776-780.
[5] Streicher, C., Zeitz, U., Andrukhova, O., et al. (2012) Long-Term Fgf23 Deficiency Does Not Influence Aging, Glucose Homeostasis, or Fat Metabolism in Mice with a Non-functioning Vitamin D Receptor. Endocrinology, 153, 1795-1805. [Google Scholar] [CrossRef] [PubMed]
[6] Berndt, T.J., Craig, T.A., McCormick, D.J., Lanske, B., Sitara, D., Razzaque, M.S., Pragnell, M., Bowe, A.E., O’Brien, S.P., Schiavi, S.C., et al. (2007) Biological Activity of FGF-23 Fragments. Pflügers Archiv—European Journal of Physiology, 454, 615-623. [Google Scholar] [CrossRef] [PubMed]
[7] Johnson, K., Levine, K., Sergi, J., Chamoun, J., Roach, R., Vekich, J., Favis, M., Horn, M., Cao, X., Miller, B., et al. (2017) Therapeutic Effects of FGF23 c-Tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia via the Selective Modulation of Phosphate Reabsorption. Journal of Bone and Mineral Research, 32, 2062-2073. [Google Scholar] [CrossRef] [PubMed]
[8] Yamashita, T., Yoshioka, M. and Itoh, N. (2000) Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain. Bio-chemical and Biophysical Research Communications, 277, 494-498. [Google Scholar] [CrossRef] [PubMed]
[9] Ho, B.B. and Bergwitz, C. (2021) FGF23 Signalling and Physiology. Journal of Molecular Endocrinology, 66, 23-32. [Google Scholar] [CrossRef] 
[10] Hu, M.C., Shiizaki, K., Kuro-o, M. and Moe, O.W. (2013) Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism. Annu-al Review of Physiology, 75, 503-533. [Google Scholar] [CrossRef] [PubMed]
[11] Lanske, B. and Razzaque, M.S. (2014) Molecular Interactions of FGF23 and PTH in Phosphate Regulation. Kidney International, 86, 1072-1074. [Google Scholar] [CrossRef] [PubMed]
[12] Krajisnik, T., Bjorklund, P., Marsell, R., et al. (2007) Fibroblast Growth Factor-23 Regulates Parathyroid Hormone and 1α-Hydroxylase Expression in Cultured Bovine Parathyroid Cells. Jour-nal of Endocrinology, 195, 125-131. [Google Scholar] [CrossRef] 
[13] He, X., Hu, X., Ma, X., et al. (2017) Elevated Serum Fibroblast Growth Factor 23 Levels as an Indicator of Lower Extremity Atherosclerotic Disease in Chinese Patients with Type 2 Diabetes Mellitus. Cardiovascular Diabetology, 16, 395-467. [Google Scholar] [CrossRef] [PubMed]
[14] Wagner, C.A., Imenez Silva, P.H. and Rubio-Aliaga, I. (2017) And the Fat Lady Sings about Phosphate and Calcium. Kidney In-ternational, 91, 270-272. [Google Scholar] [CrossRef] [PubMed]
[15] Mirza, M.A., Alsiö, J., Hammarstedt, A., Erben, R.G., Michaëlsson, K., Tivesten, A., Marsell, R., Orwoll, E., Karlsson, M.G., Ljunggren, O., et al. (2011) Circu-lating Fibroblast Growth factor-23 Is Associated with Fat Mass and Dyslipidemia in Two Independent Cohorts of Elder-ly Individuals. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 219-227. [Google Scholar] [CrossRef] 
[16] Hu, X., Ma, X., Luo, Y., et al. (2018) Associations of Se-rum Fibroblast Growth Factor 23 Levels with Obesity and Visceral Fat Accumulation. Clinical Nutrition, 37, 223-228. [Google Scholar] [CrossRef] [PubMed]
[17] 李璟. 内脏脂肪素对KKAy小鼠肝脏FGF23和BMP-9表达的影响[D]: [硕士学位论文]. 遵义: 遵义医科大学, 2021.
[18] 王翠华, 岳妍. 瘦素、脂联素与非酒精性脂肪性肝病关系的研究进展[J]. 临床肝胆病杂志, 2015, 31(8): 1351-1354.
[19] Rutkowski, J.M., Pastor, J., Sun, K., et al. (2017) Adiponectin Alters Renal Calcium and Phosphate Excretion through Regulation of Klotho Expression. Kidney Interna-tional, 91, 324-337. [Google Scholar] [CrossRef] [PubMed]
[20] 林碧娟, 林青兰, 康亚波, 等. 妊娠期糖代谢异常孕妇葡萄糖耐量试验时胰岛素的变化和临床意义[J]. 实用医技杂志, 2019, 26(3): 333-334.
[21] Fernández-Real, J.M., Puig, J., Serrano, M., et al. (2013) Iron and Obesity Status-Associated Insulin Re-sistance Influence Circulating Fibroblast-Growth Factor-23 Concentrations. PLOS ONE, 8, e58961. [Google Scholar] [CrossRef] [PubMed]
[22] Miller-Kasprzak, E., Musialik, K., Kręgielska-Narożna, M., Szulińska, M. and Bogdański, P. (2022) The Relation between Resistin (-420C/G) Single Nucleotide Variant, Resistin Serum Concentration, Carbohydrate, and Lipid Parameters and Fried Food Taste Preference in Patients with Hypertri-glyceridemia. Nutrients, 14, 5092.
[23] Curat, C.A., Wegner, V., Sengenès, C., et al. (2006) Macrophages in Human Visceral Adipose Tissue: Increased Accumulation in Obesity and a Source of Resistin and Visfatin. Diabetologia, 49, 744-747. [Google Scholar] [CrossRef] [PubMed]
[24] Steppan, C., Bailey, S., Bhat, S., et al. (2001) The Hormone Re-sistin Links Obesity to Diabetes. Nature, 409, 307-312. [Google Scholar] [CrossRef] [PubMed]
[25] Kim, K.-H., Lee, K., Moon, Y.S. and Sul, H.S. (2001) A Cysteine-Rich Adipose Tissue-Specific Secretory Factor Inhibits Adipocyte Differentiation. Journal of Biological Chemistry, 276, 11252-11256. [Google Scholar] [CrossRef] 
[26] Hanks, L.J., Casazza, K., Judd, S.E., Jenny, N.S. and Gutiérrez, O.M. (2015) Associations of Fibroblast Growth Factor-23 with Markers of Inflammation, Insulin Resistance and Obesity in Adults. PLOS ONE, 10, 122-128. [Google Scholar] [CrossRef] [PubMed]
[27] 郝小林. 血清抵抗素与糖尿病的相关性研究[J]. 中西医结合心脑血管病杂志, 2010, 8(8): 997-998.
[28] 张艳红, 王立, 杨伟. 老年2型糖尿病患者血清抵抗素水平与胰岛素抵抗的相关性研究[J]. 疑难病杂志, 2011, 10(5): 342-344.
[29] Yamazaki, Y., Tamada, T., Kasai, N., et al. (2008) Anti-FGF23 Neutralizing Antibodies Show the Physiological Role and Structural Features of FGF23. Journal of Bone and Mineral Research, 23, 1509-1518. [Google Scholar] [CrossRef] [PubMed]

为你推荐