冠心病患者左室舒张功能与胰岛素抵抗的相关性研究
Correlation Research between Left Ventricular Diastolic Function and Insulin Resistance in Patients with Coronary Heart Disease
DOI: 10.12677/ACM.2023.1361354, PDF,   
作者: 刘建菊*：青海大学研究生院，青海 西宁；张亚萍#：青海省人民医院心血管内科，青海 西宁
关键词: 胰岛素抵抗；高胰岛素血症；心血管疾病；冠心病；左室舒张功能；Insulin Resistance； Hyperinsulinemia； Cardiovascular Disease； Coronary Heart Disease； Left Ventricular Diastolic Function
摘要: 近年来的研究表明胰岛素抵抗的发生与机体炎症、氧化应激、microRNA的表达、胰岛素代谢信号通路异常以及线粒体功能障碍等诸多因素有关，这些因素导致机体组织器官出现胰岛素敏感性降低的情况，进而影响其正常功能。其中，胰岛素抵抗作为高血压、血管钙化、冠心病、心肌病、心功能不全及脂代谢异常的危险因素，已经成为当前研究的热点之一。本综述主要探讨胰岛素抵抗与冠心病左室舒张功能的发生、发展过程，可以为冠心病患者舒张功能减退的预防、治疗靶点前移提供新的思路。
Abstract: Recent studies have shown that the occurrence of insulin resistance is related to many factors such as inflammation, oxidative stress, microRNA expression, abnormal insulin metabolic signaling pathway and mitochondrial dysfunction. These factors lead to the decrease of insulin sensitivity in body tissues and organs, thus affecting their normal function. Among them, insulin resistance, as a risk factor for hypertension, vascular calcification, coronary heart disease, cardiomyopathy, cardiac insufficiency, and abnormal lipid metabolism, has become one of the current research hotspots. This review mainly discusses the occurrence and development of insulin resistance and left ven-tricular diastolic function in patients with coronary heart disease, which can provide a new idea the prevention of diastolic dysfunction in patients with coronary heart disease and the advancement of treatment target.
文章引用：刘建菊, 张亚萍. 冠心病患者左室舒张功能与胰岛素抵抗的相关性研究[J]. 临床医学进展, 2023, 13(6): 9674-9679. https://doi.org/10.12677/ACM.2023.1361354

参考文献

[1] Nick, T., Lauren, W., Prachi, B., et al. (2016) Cardiovascular Disease in Europe: Epidemiological Update 2016. Europe-an Heart Journal, 37, 3232-3245. [Google Scholar] [CrossRef] [PubMed]
[2] 基层心血管病综合管理实践指南2020 [J]. 中国医学前沿杂志(电子版), 2020, 12(8): 1-73.
[3] Kowalska, K., Wilczopolski, P., Buławska, D., et al. (2022) The Importance of SGLT-2 Inhibitors as Both the Prevention and the Treatment of Diabetic Cardiomyopathy. An-tioxidants, 11, Article No. 2500. [Google Scholar] [CrossRef] [PubMed]
[4] Kosmas, C.E., Bousvarou, M.D., Kostara, C.E., Papakonstantinou, E.J., Salamou, E. and Guzman, E. (2023) Insulin Resistance and Cardiovascular Disease. Journal of International Medi-cal Research, 51. [Google Scholar] [CrossRef] [PubMed]
[5] Ormazabal, V., Nair, S., Elfeky, O., et al. (2018) Association between Insulin Resistance and the Development of Cardiovascular Disease. Cardiovascular Diabetology, 17, Article No. 122. [Google Scholar] [CrossRef] [PubMed]
[6] 李莎, 熊峰. 胰岛素抵抗与心血管疾病研究进展[J]. 心血管病学进展, 2019, 40(9): 1307-1311. [Google Scholar] [CrossRef] 
[7] Samuel, V.T. and Shulman, G.I. (2012) Mecha-nisms for Insulin Resistance: Common Threads and Missing Links. Cell, 148, 852-871. [Google Scholar] [CrossRef] [PubMed]
[8] Hill, M.A., Yang, Y., Zhang, L., Sun, Z., Jia, G., Parrish, A.R. and Sowers, J.R. (2021) Insulin Resistance, Cardiovascular Stiffening and Cardiovascular Disease. Metabolism, 119, Article ID: 154766. [Google Scholar] [CrossRef] [PubMed]
[9] Jia, G., Whaley-Connell, A. and Sowers, J.R. (2018) Diabetic Cardiomyopathy: A Hyperglycaemia- and Insulin-Resistance-Induced Heart Disease. Diabetologia, 61, 21-28. [Google Scholar] [CrossRef] [PubMed]
[10] Riehle, C. and Abel, E.D. (2016) Insulin Signaling and Heart Failure. Circulation Research, 118, 1151-1169. [Google Scholar] [CrossRef] 
[11] Shah, A. and Shannon, R.P. (2003) Insulin Resistance in Dilated Cardiomyopathy. Reviews in Cardiovascular Medicine, 4, S50-S57.
[12] Nikolaidis, L.A., Sturzu, A., Stolarski, C., Elahi, D., Shen, Y.T. and Shannon, R.P. (2004) The Development of Myocardial Insulin Resistance in Conscious Dogs with Advanced Dilated Cardiomyopathy. Cardiovascular Research, 61, 297-306. [Google Scholar] [CrossRef] [PubMed]
[13] Dávila-Román, V.G., Vedala, G., Herrero, P., de las Fuentes, L., Rogers, J.G., Kelly, D.P., et al. (2002) Altered Myocardial Fatty Acid and Glucose Metabolism in Idiopathic Dilated Cardiomyopathy. Journal of the American College of Cardiology, 40, 271-277. [Google Scholar] [CrossRef] 
[14] Neglia, D., De Caterina, A., Marraccini, P., Natali, A., Ciardetti, M., Vecoli, C., et al. (2007) Impaired Myocardial Metabolic Reserve and Substrate Selection Flexibility during Stress in Patients with Idiopathic Dilated Cardiomyopathy. American Journal of Physiology-Heart and Circulatory Physiology, 293, H3270-H3278. [Google Scholar] [CrossRef] [PubMed]
[15] Tuunanen, H., Engblom, E., Naum, A., Scheinin, M., Någren, K., Airaksinen, J., et al. (2006) Decreased Myocardial Free Fatty Acid Uptake in Patients with Idiopathic Dilated Cardiomy-opathy: Evidence of Relationship with Insulin Resistance and Left Ventricular Dysfunction. Journal of Cardiac Failure, 12, 644-652. [Google Scholar] [CrossRef] [PubMed]
[16] Velez, M., Kohli, S. and Sabbah, H.N. (2014) Animal Models of Insulin Resistance and Heart Failure. Heart Failure Reviews, 19, 1-13. [Google Scholar] [CrossRef] [PubMed]
[17] Hill, M.A., Jaisser, F. and Sowers, J.R. (2022) Role of the Vas-cular Endothelial Sodium Channel Activation in the Genesis of Pathologically Increased Cardiovascular Stiffness. Cardi-ovascular Research, 118, 130-140. [Google Scholar] [CrossRef] [PubMed]
[18] Hong, Z., Sun, Z., Li, M., Li, Z., Bunyak, F., Ersoy, I., Trzeciakowski, J.P., Staiculescu, M.C., Jin, M., Martinez-Lemus, L., Hill, M.A., Palaniappan, K. and Meininger, G.A. (2014) Vasoac-tive Agonists Exert Dynamic and Coordinated Effects on Vascular Smooth Muscle Cell Elasticity, Cytoskeletal Remodel-ling and Adhesion. The Journal of Physiology, 592, 1249-1266. [Google Scholar] [CrossRef] [PubMed]
[19] Kleyman, T.R., Kashlan, O.B. and Hughey, R.P. (2018) Epithe-lial Na+ Channel Regulation by Extracellular and Intracellular Factors. Annual Review of Physiology, 80, 263-281. [Google Scholar] [CrossRef] [PubMed]
[20] Pearce, D., Soundararajan, R., Trimpert, C., Kashlan, O.B., Deen, P.M. and Kohan, D.E. (2015) Collecting Duct Principal Cell Transport Processes and Their Regulation. Clinical Journal of the American Society of Nephrology, 10, 135-146. [Google Scholar] [CrossRef] 
[21] Blazer-Yost, B.L., Esterman, M.A. and Vlahos, C.J. (2003) Insu-lin-Stimulated Trafficking of ENaC in Renal Cells Requires PI 3-Kinase Activity. American Journal of Physiology-Cell Physiology, 284, C1645-C1653. [Google Scholar] [CrossRef] [PubMed]
[22] Jia, G., Habibi, J., Aroor, A.R., Hill, M.A., DeMarco, V.G., Lee, L.E., Ma, L., Barron, B.J., Whaley-Connell, A. and Sowers, J.R. (2018) Enhanced Endothelium Epithelial Sodium Channel Signaling Prompts Left Ventricular Diastolic Dysfunction in Obese Female Mice. Metabolism, 78, 69-79. [Google Scholar] [CrossRef] [PubMed]
[23] Jia, G., Habibi, J., Aroor, A.R., Martinez-Lemus, L.A., De-Marco, V.G., Ramirez-Perez, F.I., Sun, Z., Hayden, M.R., Meininger, G.A., Mueller, K.B., Jaffe, I.Z. and Sowers, J.R. (2016) Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females. Circulation Research, 118, 935-943. [Google Scholar] [CrossRef] 
[24] Sowers, J.R., Habibi, J., Aroor, A.R., Yang, Y., Lastra, G., Hill, M.A., Whaley-Connell, A., Jaisser, F. and Jia, G. (2019) Epithelial Sodium Channels in Endothelial Cells Medi-ate Diet-Induced Endothelium Stiffness and Impaired Vascular Relaxation in Obese Female Mice. Metabolism, 99, 57-66. [Google Scholar] [CrossRef] [PubMed]
[25] Drummond, H.A., Grifoni, S.C. and Jernigan, N.L. (2008) A New Trick for an Old Dogma: ENaC Proteins as Mechanotransducers in Vascular Smooth Muscle. Physiology, 23, 23-31. [Google Scholar] [CrossRef] [PubMed]
[26] Jia, G., Habibi, J., Aroor, A.R., Hill, M.A., Yang, Y., Whaley-Connell, A., Jaisser, F. and Sowers, J.R. (2018) Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction. Hypertension, 72, 731-738. [Google Scholar] [CrossRef] 
[27] Fels, J., Jeggle, P., Liashkovich, I., Peters, W. and Oberleithner, H. (2014) Nanomechanics of Vascular Endothelium. Cell and Tissue Research, 355, 727-737. [Google Scholar] [CrossRef] [PubMed]
[28] Fang, Z.Y., Prins, J.B. and Marwick, T.H. (2004) Diabetic Car-diomyopathy: Evidence, Mechanisms, and Therapeutic Implications. Endocrine Reviews, 25, 543-567. [Google Scholar] [CrossRef] [PubMed]
[29] Jia, G., DeMarco, V.G. and Sowers, J.R. (2016) Insulin Resistance and Hyperinsulinaemia in Diabetic Cardiomyopathy. Nature Reviews Endocrinology, 12, 144-153. [Google Scholar] [CrossRef] [PubMed]
[30] Mandavia, C.H., Aroor, A.R., Demarco, V.G. and Sowers, J.R. (2013) Molecular and Metabolic Mechanisms of Cardiac Dysfunction in Diabetes. Life Sciences, 92, 601-608. [Google Scholar] [CrossRef] [PubMed]
[31] Vincent, M.A., Clerk, L.H., Lindner, J.R., Klibanov, A.L., Clark, M.G., Rattigan, S. and Barrett, E.J. (2004) Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake in Vivo. Diabetes, 53, 1418-1423. [Google Scholar] [CrossRef] [PubMed]
[32] Paolillo, S., Rengo, G., Pellegrino, T., Formisano, R., Pagano, G., Gargiulo, P., Savarese, G., Carotenuto, R., Petraglia, L., Ra-pacciuolo, A., Perrino, C., Piscitelli, S., Attena, E., Del Guercio, L., Leosco, D., Trimarco, B., Cuocolo, A. and Perro-ne-Filardi, P. (2015) Insulin Resistance Is Associated with Impaired Cardiac Sympathetic Innervation in Patients with Heart Failure. European Heart Journal-Cardiovascular Imaging, 16, 1148-1153. [Google Scholar] [CrossRef] [PubMed]

为你推荐