光动力疗法在HPV感染生殖系统相关疾病的研究现况

Current Status of Photodynamic Therapy in HPV Infection of Reproductive System Related Diseases

摘要: 人乳头瘤病毒(Human Papilloma Virus, HPV)是众多女性疾病的主要致病因素。虽然HPV疫苗已经得到广泛推广，但与HPV感染相关的生殖系统相关疾病，包括宫颈或外阴癌、癌前病变、各种生殖器疣等发病率仍居高不下，给广大女性的健康带来巨大威胁。常规的治疗方法往往因为潜在的副作用及耐药性在临床应用上受限。目前各种基于光的技术如光控离子通道、光活化等已经被熟练应用于临床治疗。近年来，利用光、光敏剂及氧气共同发挥作用的光动力疗法以无创性、高效性的优势获得研究者们的密切关注。本文旨在回顾光动力疗法在HPV感染生殖系统相关疾病中的现代研究和临床应用，提高妇科医生对光动力疗法重要性的认识。

Abstract: Human Papilloma Virus (HPV) is the main pathogenic factor of many female diseases. Although HPV vaccine has been widely promoted, the incidence of reproductive system diseases related to HPV infection, including cervical or vulvar cancer, precancerous lesions, and various genital warts, re-mains high, posing a great threat to the health of women. Conventional treatments are often limited in clinical use because of potential side effects and drug resistance. At present, various light-based technologies such as light-controlled ion channels and photoactivation have been skillfully applied in clinical treatment. In recent years, photodynamic therapy, which uses light, photosensitizer and oxygen together, has been paid close attention by researchers for its advantages of non-invasive and high efficiency. The purpose of this paper is to review the modern research and clinical application of photodynamic therapy in HPV infection related diseases of the reproductive system, and to raise the awareness of the importance of photodynamic therapy among gynecologists.