植物雌激素在心肌再灌注损伤线粒体自噬中的研究进展
Development of Phytoestrogens in Mitophagy in Myocardial Reperfusion Injury
DOI: 10.12677/ACM.2023.1361363, PDF,    科研立项经费支持
作者: 张 惠*, 杨金新, 强明敏, 尹 佳：延安大学医学院内科学，陕西 延安；高宇勤#：西安市第九医院心血管内科，陕西 西安
关键词: 植物雌激素；心肌缺血再灌注损伤；线粒体自噬；Phytoestrogens； Myocardial Ischemia Reperfusion Injury； Mitophagy
摘要: 心肌缺血再灌注损伤一直是临床亟待解决的难题，药物预处理是一种有效的治疗措施。其中雌激素药物预处理可通过调控线粒体自噬减轻再灌注损伤，但由于雌激素众多副作用限制其在临床中的应用。黄酮类、木脂素类、二苯乙烯类及香豆素类植物雌激素因具有雌激素样作用及更高的安全性，可作为雌激素替代治疗方案，通过调控线粒体自噬减轻再灌注损伤。本文将就线粒体自噬对再灌注损伤的影响、植物雌激素在此方面的研究进展展开论述，旨在为临床预防和治疗缺血再灌注损伤提供新思路。
Abstract: Myocardial ischemia-reperfusion injury has always been an urgent clinical problem, and pharma-cological preconditioning is an effective treatment. Among them, estrogen drug pretreatment can attenuate reperfusion injury by regulating mitophagy, but due to the numerous side effects of es-trogen, it limits its use in the clinic. Phytoestrogens, such as flavonoids, lignans, stilbenes, and cou-marins, because of their estrogen like effects and higher safety profiles, may be used as estrogen alternative treatments to attenuate reperfusion injury by modulating mitophagy. This review will deal with the impact of mitophagy on reperfusion injury, the progress of phytoestrogens in this area, aiming to provide new ideas for clinical prevention and treatment of ischemia-reperfusion injury.
文章引用：张惠, 高宇勤, 杨金新, 强明敏, 尹佳. 植物雌激素在心肌再灌注损伤线粒体自噬中的研究进展[J]. 临床医学进展, 2023, 13(6): 9735-9742. https://doi.org/10.12677/ACM.2023.1361363

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