卒中后癫痫发病机制的研究进展

The Research Progress of Epileptic Seizures after Stroke and Its Mechanisms

摘要: 脑卒中是癫痫发生的常见原因之一，脑卒中的发生率随着预期寿命的延长而增加，脑卒中后癫痫(post-stroke epilepsy, PSE)的患病率也在上升。脑卒中后的癫痫发作类型多样，癫痫的发生与脑卒中的类型和部位密切相关。而且脑卒中后癫痫的临床治疗困难，增加了患者致残和死亡的风险，影响患者的预后和生活质量。目前脑卒中后癫痫和癫痫越来越受到医学界的重视，已经有越来越多的研究者致力于癫痫和PSE的临床和基础研究，并希望得到科学统一的指导意见，给予及时有效的治疗，但确切的病理生理机制尚未形成统一的结论。因此，本文针对近年来对脑卒中后癫痫发生机制的研究进展作一综述，以期为临床医生认识该病提供依据，为今后的探索提供思路。

Abstract: Stroke is one of the common causes of epilepsy, and the incidence of stroke increases with life ex-pectancy, as does the prevalence of post-stroke epilepsy (PSE). There are various types of epilepsy after stroke, and the occurrence of epilepsy is closely related to the type and site of stroke. Moreo-ver, the clinical treatment of post-stroke epilepsy is difficult, which increases the risk of disability and death, and affects the prognosis and quality of life of patients. At present, post-stroke epilepsy and epilepsy have received more and more attention from the medical community. More and more researchers have been committed to clinical and basic research on epilepsy and PSE, hoping to ob-tain unified scientific guidance and timely and effective treatment, but the exact pathophysiological mechanism has not yet reached a unified conclusion. Therefore, this paper reviews the research progress on the pathogenesis of epilepsy after stroke in recent years, in order to provide a basis for clinicians to understand the disease and provide ideas for future exploration.