蛋白质S-棕榈酰化在T细胞信号传导中的研究进展
Research Progress on Protein S-Palmitoylation in T-Cell Signaling Transduction
DOI: 10.12677/BP.2023.132016, PDF,   
作者: 戴心忱*：中国药科大学生命科学与技术学院，江苏 南京；中国医学科学院北京协和医学院苏州系统医学研究所，江苏 苏州；张为国：中国医学科学院北京协和医学院苏州系统医学研究所，江苏 苏州；陆美玲*：中国药科大学生命科学与技术学院，江苏 南京
关键词: S-棕榈酰化；DHHC蛋白家族；T细胞信号传导；进展； S-Palmitoylation； DHHC Protein Family； T-Cell Signaling Transduction； Progress
摘要: 蛋白质S-棕榈酰化是一种高度动态的翻译后脂质化修饰，由DHHC蛋白家族催化，在调节蛋白质定位、稳定性和细胞内转运等方面发挥重要作用。近年来，随着T细胞免疫疗法的兴起，对于T细胞信号通路的研究也愈发深入。大量证据表明，T细胞活化过程中，有很多关键信号分子是S-棕榈酰化的，它们的稳定表达和质膜定位对于免疫信号的传递是必需的。因此，本文总结了DHHC蛋白家族和蛋白质S-棕榈酰化的机制，并基于S-棕榈酰化在T细胞信号传导中的不同作用，分析了靶向S-棕榈酰化治疗免疫疾病的潜力和挑战。
Abstract: Protein S-palmitoylation is a highly dynamic post-translational lipid modification catalyzed by the DHHC protein family which plays an important role in regulating pro-tein localization, stability and intracellular translocation. In recent years, there has been a surge of interest in T-cell-based immunotherapy, leading to a deeper investigation of T-cell signaling path-ways. A large amount of evidence indicates that many pivotal signaling molecules involved in T-cell activation are modified by S-palmitoylation, which is essential for their stable expression and plas-ma membrane localization, and thus for proper immune signaling. Therefore, in this review, we summarize the DHHC protein family and the mechanism of protein S-palmitoylation, and analyze the potential and challenges of targeting S-palmitoylation for immune diseases based on the differ-ent roles of S-palmitoylation in T-cell signaling transduction.
文章引用：戴心忱, 张为国, 陆美玲. 蛋白质S-棕榈酰化在T细胞信号传导中的研究进展[J]. 生物过程, 2023, 13(2): 115-123. https://doi.org/10.12677/BP.2023.132016

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