糖皮质激素诱发类固醇肌病的研究现状
Research Status of Glucocorticoid Inducing Steroid Myopathy
DOI: 10.12677/ACM.2023.1361379, PDF,   
作者: 侯洪美:青海大学研究生院,青海 西宁;梅 峰*:青海大学附属医院肾内科,青海 西宁
关键词: 类固醇肌病糖皮质激素肌病 Glucocorticoid Myopathy>
摘要: 糖皮质激素作为一种抗炎及免疫抑制剂,是各种自身免疫性疾病的重要药物。但如果使用不当或在少数敏感个体中使用,则可诱发类固醇肌病(steroid myopathy, SM)。糖皮质激素过量是导致肌肉萎缩的关键因素,近年来研究者越来越关注糖皮质激素对肌肉的影响,加大了对SM发病机制及诊断的研究,促进对整个类固醇肌病的了解。下列对该病整体认识进行综述如下。
Abstract: Glucocorticoid, as an anti-inflammatory and immunosuppressant, is an important drug for various autoimmune diseases. However, if it is used improperly or in a small number of sensitive individu-als, it can induce steroid myopathy (SM). Excessive glucocorticoid is a key factor leading to muscle atrophy. In recent years, researchers have paid more and more attention to the influence of gluco-corticoid on muscle, increasing the research on the pathogenesis and diagnosis of SM, and promot-ing the understanding of the whole steroid myopathy. The overall understanding of the disease is summarized below.
文章引用:侯洪美, 梅峰. 糖皮质激素诱发类固醇肌病的研究现状[J]. 临床医学进展, 2023, 13(6): 9860-9870. https://doi.org/10.12677/ACM.2023.1361379

参考文献

[1] 文振华, 李敬扬. 甲泼尼龙致急性类固醇肌病一例讨论[J]. 临床误诊误治, 2012, 25(2): 58-60.
[2] Minetto, M.A., Lanfranco, F., Motta, G., et al. (2011) Steroid Myopathy: Some Unresolved Issues. Journal of Endocrinological Investigation, 34, 370-375. [Google Scholar] [CrossRef
[3] Cushing, H. (1932) The Basophil Adenoma of the Pituitary Body and Their Clinical Manifestation. The Johns Hopkins Medical Journal, 50, 137-195. [Google Scholar] [CrossRef
[4] Alshekhlee, A., Kaminski, H.J. and Ruff, R.L. (2002) Neuromuscular Manifestations of Endocrine Disorders. Neurologic Clinics, 20, 35-58. [Google Scholar] [CrossRef
[5] Miller, M.L. (2009) Glucocorticoid-Induced Myopathy. Up to Date, Version 16.3.
[6] 周彬, 刘建, 朱静, 龙武彬, 吴晓丹. 糖皮质激素类药物的不良反应和并发症[J]. 中国药业, 2002(6): 43-44.
[7] 刘媛, 韩艳庆. 类固醇肌病的研究现状[J]. 职业与健康, 2016, 32(11): 1556-1558.
[8] Haller, J., Mikics, E. and Makara, G.B. (2007) The Effects of Non-Genomic Glucocorticoid Mecha-nisms on Bodily Functions and the Central Neural System. A Critical Evaluation of Findings. Frontiers in Neuroendo-crinology, 29, 273-291. [Google Scholar] [CrossRef] [PubMed]
[9] Mozaffar, T., Haddad, F., Zeng, M., et al. (2007) Molecular and Cellular Defects of Skeletal Muscle in an Animal Model of Acute Quadriplegic Myopathy. Muscle Nerve, 35, 55-65. [Google Scholar] [CrossRef] [PubMed]
[10] Hanson, P., Dive, A., Brucher, J.M., et al. (1997) Acute Corticosteroid Myopathy in Intensive Care Patients. Muscle Nerve, 20, 1371-1380. [Google Scholar] [CrossRef
[11] Schakman, O., Gil-son, H. and Thissen, J.P. (2008) Mechanisms of Glucocorticoid-Induced Myopathy. Journal of Endocrinology, 197, 1-10. [Google Scholar] [CrossRef
[12] DuBois, D.C. and Almon, R.R. (1980) Disuse Atrophy of Skeletal Muscle Is Associated with an Increase in Number of Glucocorticoid Receptors. Endocrinology, 107, 1649-1651. [Google Scholar] [CrossRef] [PubMed]
[13] 杨强, 聂秀红, 滕国杰. 甲泼尼龙和维库溴铵联用相关急性类固醇肌病[J]. 药物不良反应杂志, 2011, 13(5): 314-315.
[14] Hasselgren, P.O. (1999) Glucocorticoids and Muscle Ca-tabolism. Current Opinion in Clinical Nutrition & Metabolic Care, 2, 201-205. [Google Scholar] [CrossRef] [PubMed]
[15] Combaret, L., Adegoke, O.A., Bedard, N., et al. (2005) USP19 Is a Ubiquitin-Specific Protease Regulated in Rat Skeletal Muscle during Catabolic States. American Journal of Physiology-Endocrinology and Metabolism, 288, E693-E700. [Google Scholar] [CrossRef] [PubMed]
[16] Du, J., Mcewen, B. and Manji, H.K. (2009) Glucocorticoid Re-ceptors Modulate Mitochondrial Function: A Novel Mechanism for Neuroprotection. Communicative & Integrative Bi-ology, 2, 350-352. [Google Scholar] [CrossRef] [PubMed]
[17] Rich, M.M. and Pinter, M.J. (2003) Crucial Role of Sodium Channel Fast Inactivation in Muscle Fibre Inexcitability in a Rat Model of Critical Illness Myopathy. The Journal of Physiology, 547, 555-566. [Google Scholar] [CrossRef] [PubMed]
[18] Inder, W.J., Jang, C., Obeyesekere, V.R. and Alford, F.P. (2009) Dexamethasone Administration Inhibits Skeletal Muscle Expression of the Androgen Receptor and IGF-1—Implications for Steroid-Induced Myopathy. Clinical Endocrinology, 73, 126-132. [Google Scholar] [CrossRef] [PubMed]
[19] Gayan-Ramirez, G., Vanderhoydonc, F., Verhoeven, G. and Decramer, M. (1999) Acute Treatment with Corticosteroids Decreases IGF-1 and IGF-2 Expression in the Rat Dia-phragm and Gastrocnemius. American Journal of Respiratory and Critical Care Medicine, 159, 283-289. [Google Scholar] [CrossRef] [PubMed]
[20] Haran, M., Schattner, A., Kozak, N., Kozak, N. and Mate, A. (2018) Acute Steroid Myopathy: A Highly Overlooked Entity. QJM: Monthly Journal of the Association of Physicians, 111, 307-311. [Google Scholar] [CrossRef] [PubMed]
[21] Pereira, R.M.R. and Freire de Carvalho, J. (2011) Glu-cocorticoid-Induced Myopathy. Joint Bone Spine, 78, 41-44. [Google Scholar] [CrossRef] [PubMed]
[22] Van Balkom, R.H., van Der Heijden, H.F., van Herwaarden, C.L. and Dekhuijzen, P.N. (1994) Corticosteroid Induced Myopathy of the Respiratory Muscles. The Netherlands Journal of Medicine, 45, 114-122.
[23] Gupta, A. and Gupta, Y. (2013) Glucocorticoid-Induced Myopathy: Pathophysiology, Di-agnosis, and Treatment. Indian Journal of Endocrinology and Metabolism, 17, 913-916. [Google Scholar] [CrossRef] [PubMed]
[24] Sapega, A.A. (1990) Muscle Performance Evaluation in Orthopae-dic Practice. The Journal of Bone and Joint Surgery. American Volume, 72, 1562-1574. [Google Scholar] [CrossRef
[25] Bohannon, R.W. (2001) Measuring Knee Extensor Muscle Strength. American Journal of Physical Medicine & Rehabilitation, 80, 13-18. [Google Scholar] [CrossRef] [PubMed]
[26] Maffiuletti, N.A. (2010) Assessment of Hip and Knee Muscle Function in Orthopaedic Practice and Research. The Journal of Bone and Joint Surgery. American Volume, 92, 220-229. [Google Scholar] [CrossRef
[27] Baudry, S., Lanfranco, F., Merletti, R., Duchateau, J. and Mi-netto, M.A. (2014) Effects of Short-Term Dexamethasone Administration on Corticospinal Excitability. Medicine & Sci-ence in Sports & Exercise, 46, 695-701. [Google Scholar] [CrossRef
[28] 周磊, 赵重波, 朱雯华, 等. 类固醇肌病的临床和病理特点分析(附10例报道) [J]. 中国临床神经科学, 2011, 19(6): 583-587.
[29] Bielefeld, P. (1996) Present Status of Cortisone Myopathy. La Revue de Medecine Interne, 17, 255-261. [Google Scholar] [CrossRef] [PubMed]
[30] Lukaski, H.C., Bolonchuk, W.W., Hall, C.B. and Siders, W.A. (1986) Validation of Tetrapolar Bioelectrical Impedance Method to Assess Human Body Composition. Journal of Ap-plied Physiology, 60, 1327-1332. [Google Scholar] [CrossRef] [PubMed]
[31] Kendler, D.L., Borges, J.L., Fielding, R.A., Itabashi, A., Krueger, D., Mulligan, K., Camargos, B.M., Sabowitz, B., Wu, C.H., Yu, E.W. and Shepherd, J. (2013) The Official Positions of the International Society for Clinical Densitometry: Indications of Use and Reporting of DXA for Body Composition. Journal of Clinical Densitometry, 16, 496-507. [Google Scholar] [CrossRef] [PubMed]
[32] Janssen, S.B., Heymsfield, R.N. and Baumgartner, R. (2000) Ross, Estimation of Skeletal Muscle Mass by Bioelectrical Impedance Analysis. Journal of Applied Physiology, 89, 465-471. [Google Scholar] [CrossRef] [PubMed]
[33] Sergi, G., De Rui, M., Veronese, N., Bolzetta, F., Berton, L., Carraro, S., Bano, G., Coin, A., Manzato, E. and Perissinotto, E. (2015) Assessing Appendicular Skeletal Muscle Mass with Bioelectrical Impedance Analysis in Free-Living Caucasian Older Adults. Clinical Nutrition, 34, 667-673. [Google Scholar] [CrossRef] [PubMed]
[34] Baumgartner, R.N., Koehler, K.M., Gallagher, D., Romero, L., Heymsfield, S.B., Ross, R.R., Garry, P.J. and Lindeman, R.D. (1998) Epidemiology of Sarcopenia among the Elderly in New Mexico. American Journal of Epidemiology, 147, 755-763. [Google Scholar] [CrossRef] [PubMed]
[35] Janssen, S.B., Heymsfield, Z.M. and Wang, R. (2000) Ross, Skeletal Muscle Mass and Distribution in 468 Men and Women Aged 18 - 88 yr. Journal of Applied Physiology (1985), 89, 81-88. [Google Scholar] [CrossRef] [PubMed]
[36] Janssen, I., Baumgartner, R.N., Ross, R., Ros-enberg, I.H. and Roubenoff, R. (2004) Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women. American Journal of Epidemiology, 159, 413-421. [Google Scholar] [CrossRef] [PubMed]
[37] Cawthon, P.M., Peters, K.W., Shardell, M.D., McLean, R.R., Dam, T.T., Kenny, A.M., et al. (2014) Cutpoints for Low Appendicular Lean Mass That Identify Older Adults with Clinically Sig-nificant Weakness. The Journals of Gerontology: Series A Biological Sciences and Medical Sciences, 69, 567-575. [Google Scholar] [CrossRef] [PubMed]
[38] Khaleeli, A.A., Betteridge, D.J., Edwards, R.H., Round, J.M. and Ross, E.J. (1983) Effect of Treatment of Cushing’s Syndrome on Skeletal Muscle Structure and Function. Clinical Endocri-nology (Oxford), 19, 547-556. [Google Scholar] [CrossRef] [PubMed]
[39] Miller, B.S., Ignatoski, K.M., Daignault, S., Lindland, C., Gauger, P.G., Doherty, G.M. and Wang, S.C. (2011) A Quantitative Tool to Assess Degree of Sarcopenia Objectively in Patients with Hypercortisolism. Surgery, 150, 1178-1185. [Google Scholar] [CrossRef] [PubMed]
[40] Lovitt, S., Marden, F.A., Gundogdu, B. and Ostrowski, M.L. (2004) MRI in Myopathy. Neurologic Clinics, 22, 509-538. [Google Scholar] [CrossRef] [PubMed]
[41] Zoico, E., Corzato, F., Bambace, C., Rossi, A.P., Micciolo, R., Cinti, S., Harris, T.B. and Zamboni, M. (2013) Myosteatosis and Myofibrosis: Relationship with Aging, Inflammation and In-sulin Resistance. Archives of Gerontology and Geriatrics, 57, 411-416. [Google Scholar] [CrossRef] [PubMed]
[42] 刘美快, 陈斌. 定量超声评估肌肉功能研究进展[J]. 中国介入影像与治疗学, 2018, 15(12): 769-772. [Google Scholar] [CrossRef
[43] Cortez, C.D., Hermitte, L., Ramain, A., Mesmann, C., Lefort, T. and Pialat, J.B. (2016) Ultrasound Shear Wave Velocity in Skeletal Muscle: A Reproducibility Study. Diag-nostic and Interventional Imaging, 97, 71-79. [Google Scholar] [CrossRef] [PubMed]
[44] Simon, N.G. (2019) A New Diagnostic Tool for the Detection of Steroid Myopathy. Clinical Neurophysiology, 130, 1407-1408. [Google Scholar] [CrossRef] [PubMed]
[45] Khwaja, G.A., Chaudhry, N., Kushwaha, R.S., Garg, R., Ranjan, R., Gupta, M., et al. (2009) Acute Myopathy Following Short-Term Low-Dose Oral Steroid Therapy. Journal, Indian Academy of Clinical Medicine, 10, 65-68.
[46] Sun, L.Y. and Chu, X.L. (2017) Acute Myopathy Following In-tra-Muscular Injection of Compound Betamethasone. Medicine (Baltimore), 96, e7474. [Google Scholar] [CrossRef
[47] Cruz-Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T., Landi, F., et al. (2010) Sarcopenia: European Consensus on Definition and Diagnosis: Report of the Eu-ropean Working Group on Sarcopenia in Older People. Age and Ageing, 39, 412-423. [Google Scholar] [CrossRef] [PubMed]
[48] Studenski, S.A., Peters, K.W., Alley, D.E., Cawthon, P.M., McLean, R.R., Harris, T.B., et al. (2014) The FNIH Sarcopenia Project: Rationale, Study Description, Recommendations, and Fi-nal Estimates. The Journals of Gerontology: Series A Biological Sciences and Medical Sciences, 69, 547-558. [Google Scholar] [CrossRef] [PubMed]
[49] Naim, M.Y. and Reed, A.M. (2006) Enzyme Elevation in Patients with Juvenile Dermatomyositis and Steroid Myopathy. The Journal of Rheumatology, 33, 1392- 1394
[50] 邱承高. 阿发骨化醇预防肾上腺皮质类固醇肌病24例疗效观察[J]. 海南医学, 2010, 21(10): 31-32.
[51] Schakman, O., Gilson, H., de Coninck, V., Lause, P., Verniers, J., Havaux, X., et al. (2005) Insulin-Like Growth Factor-I Gene Transfer by Elec-troporation Prevents Skeletal Muscle Atrophy in Glucocorticoid-Treated Rats. Endocrinology, 146, 1789-1797. [Google Scholar] [CrossRef] [PubMed]
[52] Gilson, H., Schakman, O., Combaret, L., Lause, P., Grobet, L., Attaix, D., et al. (2007) Myostatin Gene Deletion Prevents Glucocorticoid-Induced Muscle Atrophy. Endocrinology, 148, 452-460. [Google Scholar] [CrossRef] [PubMed]
[53] Crawford, B.A., Liu, P.Y., Kean, M.T., Bleasel, J.F. and Handelsman, D.J. (2003) Randomized Placebo-Controlled Trial of Androgen Effects on Muscle and Bone in Men Re-quiring Long Term Systemic Glucocorticoid Treatment. Journal of Clinical Endocrinology and Metabolism, 88, 3167-3176. [Google Scholar] [CrossRef] [PubMed]
[54] Jones, A., Hwang, D.J., Narayanan, R., Miller, D.D. and Dalton, J.T. (2010) Effects of a Novel Selective Androgen Receptor Modulator on Dexamethasone-Induced and Hy-pogonadism-Induced Muscle Atrophy. Endocrinology, 151, 3706-3719. [Google Scholar] [CrossRef] [PubMed]
[55] Van Balkom, R.H., Dekhuijzen, P.N., Folgering, H.T., Veerkamp, J.H., Van Moerkerk, H.T., Fransen, J.A., et al. (1998) Anabolic Steroids in Part Reverse Glucocorticoid-Induced Alterations in Rat Diaphragm. Journal of Applied Physiology, 84, 1492-1499. [Google Scholar] [CrossRef] [PubMed]
[56] Ferrando, A.A., Sheffield-Moore, M., Yeckel, C.W., Gilkison, C., Jiang, J., Achacosa, A., et al. (2002) Testosterone Administration to Older Men Improves Muscle Function: Molecu-lar and Physiological Mechanisms. American Journal of Physiology: Endocrinology and Metabolism, 282, E601-E607. [Google Scholar] [CrossRef] [PubMed]
[57] Wu, Y., Zhao, W., Zhao, J., Pan, J., Wu, Q., Zhang, Y., et al. (2007) Identification of Androgen Response Elements in the Insulin-Like Growth Factor I Upstream Promoter. Endocri-nology, 148, 2984-2993. [Google Scholar] [CrossRef] [PubMed]
[58] Wu, Y., Zhao, W., Zhao, J., Zhang, Y., Qin, W., Pan, J., et al. (2010) REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss. Endocrinology, 151, 1050-1059. [Google Scholar] [CrossRef] [PubMed]
[59] Zhao, W., Pan, J., Wang, X., Wu, Y., Bauman, W.A. and Cardozo, C.P. (2008) Expression of the Muscle Atrophy Factor Muscle Atrophy F-Box Is Suppressed by Testosterone. Endocrinology, 149, 5449-5460. [Google Scholar] [CrossRef] [PubMed]
[60] Yamamoto, D., Maki, T., Herningtyas, E.H., Ikeshita, N., Shibahara, H., Sugiyama, Y., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., et al. (2010) Branched-Chain Amino Acids Protect against Dexamethasone-Induced Soleus Muscle Atrophy in Rats. Muscle Nerve, 41, 819-827. [Google Scholar] [CrossRef] [PubMed]
[61] Hickson, R.C., Wegrzyn, L.E., Osborne, D.F. and Karl, I.E. (1996) Ala-nyl-Glutamine Prevents Muscle Atrophy and Glutamine Synthetase Induction by Glucocorticoids. The American Journal of Physiology, 271, R1165-R1172. [Google Scholar] [CrossRef
[62] Salehian, B., Mahabadi, V., Bilas, J., Taylor, W.E. and Ma, K. (2006) The Effect of Glutamine on Prevention of Glucocorticoid-Induced Skeletal Muscle Atrophy Is Associated with Myostatin Suppression. Metabolism: Clinical and Experimental, 55, 1239-1247. [Google Scholar] [CrossRef] [PubMed]
[63] Hickson, R.C., Oehler, D.T., Byerly, R.J. and Unterman, T.G. (1997) Protective Effect of Glutamine from Glucocorticoid-Induced Muscle Atrophy Occurs without Alterations in Cir-culating Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein Levels. Proceedings of the Society for Experi-mental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 216, 65-71. [Google Scholar] [CrossRef] [PubMed]
[64] Smith, G.I., Atherton, P., Reeds, D.N., Mohammed, B.S., Ran-kin, D., Rennie, M.J. and Mittendorfer, B. (2011) Omega-3 Polyunsaturated Fatty Acids Augment the Muscle Protein Anabolic Response to Hyperinsulinaemia-Hyperaminoacidaemia in Healthy Young and Middle-Aged Men and Women. Clinical Science, 121, 267-278. [Google Scholar] [CrossRef
[65] Smith, G.I., Atherton, P., Reeds, D.N., Mohammed, B.S., Rankin, D., Rennie, M.J. and Mittendorfer, B. (2011) Dietary Omega-3 Fatty Acid Supplementation Increases the Rate of Muscle Protein Synthesis in Older Adults: A Randomized Controlled Trial. The American Journal of Clinical Nutrition, 93, 402-412. [Google Scholar] [CrossRef] [PubMed]
[66] Smith, G.I., Julliand, S., Reeds, D.N., Sinacore, D.R., Klein, S. and Mittendorfer, B. (2015) Fish Oil Derived n-3 PUFA Therapy Increases Muscle Mass and Function in Healthy Older Adults. The American Journal of Clinical Nutrition, 102, 115-122. [Google Scholar] [CrossRef] [PubMed]
[67] Shin, S.K., Kim, J.H., Lee, J.H., Son, Y.H., Lee, M.W., Kim, H.J., Noh, S.A., Kim, K.P., Kim, I.G. and Lee, M.J. (2017) Docosahexaenoic Acid-Mediated Protein Aggregates May Reduce Proteasome Activity and Delay Myotube Degradation during Muscle Atrophy in Vitro. Experimental & Molecular Medi-cine, 49, e287. [Google Scholar] [CrossRef] [PubMed]
[68] Uozumi, Y., Ito, T., Takahashi, K., Matsuda, T. and Mohri, T. (2006) Myogenic Induction of Taurine Transporter Prevents Dexamethasone-Induced Muscle Atrophy. Advances in Experi-mental Medicine and Biology, 583, 265-270. [Google Scholar] [CrossRef] [PubMed]
[69] Uozumi, Y., Ito, T., Hoshino, Y., Mohri, T. and Maeda, M. (2006) Myogenic Differentiation Induces Taurine Transporter in Association with Taurine-Mediated Cytoprotection in Skeletal Muscles. The Biochemical Journal, 394, 699-706. [Google Scholar] [CrossRef
[70] Gao, J., Lin, H., Wang, X.J., Song, Z.G. and Jiao, H.C. (2010) Vitamin E Supplementation Alleviates the Oxidative Stress Induced by Dexamethasone Treatment and Improves Meat Quality in Broiler Chickens. Poultry Science, 89, 318-327. [Google Scholar] [CrossRef] [PubMed]
[71] Lappe, J.M. and Binkley, N. (2015) Vitamin D and Sarcopenia/Falls. Journal of Clinical Densitometry, 18, 478-482. [Google Scholar] [CrossRef] [PubMed]
[72] Dzik, K.P., Skrobot, W., Kaczor, K.B., Flis, D.J., Karnia, M.J., Li-bionka, W., Antosiewicz, J., Kloc, W. and Kaczor, J.J. (2019) Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Oxidative Medicine and Cellular Longev-ity, 2019, Article ID: 6835341. [Google Scholar] [CrossRef] [PubMed]
[73] Hirose, Y., Onishi, T., Miura, S., Hatazawa, Y. and Kamei, Y. (2018) Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells. Journal of Nutritional Science and Vitaminology, 64, 229-232. [Google Scholar] [CrossRef] [PubMed]
[74] Aubry, E.M. and Odermatt, A. (2009) Retinoic Acid Reduces Glucocorti-coid Sensitivity in C2C12 Myotubes by Decreasing 11β-Hydroxysteroid Dehydrogenase Type 1 and Glucocorticoid Re-ceptor Activities. Endocrinology, 150, 2700-2708. [Google Scholar] [CrossRef] [PubMed]
[75] Takisawa, S., Fu-nakoshi, T., Yatsu, T., Nagata, K., Aigaki, T., Machida, S. and Ishigami, A. (2019) Vitamin C Deficiency Causes Muscle Atrophy and a Deterioration in Physical Performance. Scientific Reports, 9, Article No. 4702. [Google Scholar] [CrossRef] [PubMed]
[76] Son, Y.H., Jang, E., Kim, Y. and Lee, J.-H. (2017) Sulforaphane Prevents Dexamethasone-Induced Muscle Atrophy via Regulation of the Akt/Foxo1 Axis in C2C12 Myotubes. Biomedi-cine & Pharmacotherapy, 95, 1486-1492. [Google Scholar] [CrossRef] [PubMed]
[77] Menezes, L.G., Sobreira, C., Neder, L., Rodrigues-Junior, A.L. and Martinez, J.A. (2007) Creatine Supplementation Attenuates Corticosteroid-Induced Muscle Wasting and Impairment of Exercise Performance in Rats. Journal of Applied Physiology, 102, 698-703. [Google Scholar] [CrossRef] [PubMed]
[78] Roy, B.D., Bourgeois, J.M., Mahoney, D.J. and Tarnopolsky, M.A. (2002) Dietary Supplementation with Creatine Monohydrate Prevents Corticosteroid-Induced Attenuation of Growth in Young Rats. Canadian Journal of Physiology and Pharmacology, 80, 1008-1014. [Google Scholar] [CrossRef] [PubMed]
[79] Deldicque, L., Louis, M., Theisen, D., Nielens, H., Dehoux, M., Thissen, J.P., et al. (2005) Increased IGF mRNA in Human Skeletal Muscle after Creatine Supplementation. Medicine & Science in Sports & Exercise, 37, 731-736. [Google Scholar] [CrossRef
[80] Kline, W.O., Panaro, F.J., Yang, H. and Bodine, S.C. (2007) Rapamycin Inhibits the Growth and Muscle Sparing Effects of Clenbuterol. Journal of Applied Physiology, 102, 740-747. [Google Scholar] [CrossRef] [PubMed]
[81] Awede, B.L., Thissen, J.P. and Lebacq, J. (2002) Role of IGF-I and IGFBPs in the Changes of Mass and Phenotype Induced in Rat Soleus Muscle by Clenbuterol. Amer-ican Journal of Physiology: Endocrinology and Metabolism, 282, E31-E37. [Google Scholar] [CrossRef
[82] Pearen, M.A., Ryall, J.G., Maxwell, M.A., Ohkura, N., Lynch, G.S. and Muscat, G.E. (2006) The Orphan Nuclear Receptor, NOR-1. Is a Target of β-Adrenergic Signaling in Skeletal Muscle. Endocrinology, 147, 5217-5227. [Google Scholar] [CrossRef] [PubMed]
[83] Goncalves, D.A., Lira, E.C., Baviera, A.M., Cao, P., Zanon, N.M., Arany, Z., et al. (2009) Mechanisms Involved in 3,5-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle. Endocrinology, 150, 5395-5404. [Google Scholar] [CrossRef] [PubMed]
[84] LaPier, T.K. (1997) Glucocorticoid-Induced Muscle Atrophy. The Role of Exercise in Treatment and Prevention. Journal of Cardiopulmonary Rehabilitation, 17, 76-84. [Google Scholar] [CrossRef] [PubMed]
[85] Barel, M., Perez, O.A.B., Giozzet, V.A., Rafacho, A. and Bosqueiro, J.R. (2009) Exercise Training Prevents Hyperinsulinemia, Muscular Glycogen Loss and Muscle Atrophy Induced by Dexamethasone Treatment. European Journal of Applied Physiology, 108, 999-1007. [Google Scholar] [CrossRef] [PubMed]
[86] Biedasek, K. andres, J., Mai, K., Adams, S., Spuler, S., Fielitz, J., et al. (2011) Skeletal Muscle 11β-HSD1 Controls Glucocorticoid-Induced Proteolysis and Expression of E3 Ubiquitin Ligases Atrogin-1 and MuRF-1. PLOS ONE, 6, e16674. [Google Scholar] [CrossRef] [PubMed]
[87] Mohler, M.L., He, Y., Wu, Z.Z., Hong, S.-S. and Miller, D.D. (2007) Non-Steroidal Glucocorticoid Receptor Antagonists: The Race to Replace RU-486 for Anti-Glucocorticoid Ther-apy. Expert Opinion on Therapeutic Patents, 17, 59-81. [Google Scholar] [CrossRef] [PubMed]