基于生物信息学分析原发性醛固酮增多症潜在的核心基因
Analysis of Potential Core Genes in Primary Aldosteronism Based on Bioinformatics Analysis
摘要: 目的：运用生物信息学方法分析原发性醛固酮增多症的关键基因及涉及的信号通路。方法：从公共基因表达数据库(GEO)中下载原发性醛固酮增多症(primary aldosteronism, PA)的基因表达谱芯片GSE60042，和DNA甲基化芯片GSE60043。通过R语言对PA的转录组进行差异表达分析，对PA DNA的甲基化芯片进行差异甲基化基因筛选。通过对差异表达基因GO和KEGG富集分析筛选PA的核心基因。结论：原发性醛固酮增多症的核心基因可能是ABCB4、AQP2、ARG2和CLRN1。
Abstract: Objective: To analyze the key genes and signaling pathways of primary aldosteronism by bioinfor-matics analysis. Methods: GSE60042 gene expression microarray and GSE60043 DNA methylation microarray were used to profile primary aldosteronism from the public gene expression database (GEO). Differential expression analysis of the transcriptome of PA was performed by R language, and methylation microarrays of PA DNA were screened for differentially methylated genes. Core genes were screened by GO and KEGG enrichment analysis of differentially expressed genes. Conclusion: ABCB4, AQP2, ARG2 and CLRN1 may be the core genes of primary aldosteronism.
文章引用：代黎明, 曹彩霞, 颜廷屹, 孔越, 徐音飞. 基于生物信息学分析原发性醛固酮增多症潜在的核心基因[J]. 临床医学进展, 2023, 13(6): 9958-9968. https://doi.org/10.12677/ACM.2023.1361392

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