MHR、NLR、PLR对急性脑卒中的预测研究
The Predictive Study of MHR, NLR, PLR on Acute Stroke
DOI: 10.12677/ACM.2023.1361394, PDF,   
作者: 童家宁*:青海大学研究生院,青海 西宁;李 蓉:青海大学附属医院全科医学科,青海 西宁
关键词: MHRNLRPLR急性脑卒中MHR NLR PLR Acute Stroke
摘要: 脑卒中已经成为了我国卒中比例最高,同时会造成严重不良后果即高度致死率以及致残率的疾病,关于其的预测因素的研究逐渐增多,MHR、NLR、PLR作为新型炎症指标,越来越多的证据表明炎症过程对AIS的发展至关重要,故对急性脑卒中具有较高的预测价值。
Abstract: Stroke has become the disease with the highest proportion of stroke in China, and it can cause seri-ous adverse consequences such as high mortality and disability rates. Research on its predictive factors is gradually increasing. As new inflammatory indicators, MHR, NLR, and PLR, more and more evidence shows that the inflammatory process is crucial for the development of AIS, so it has high predictive value for acute stroke.
文章引用:童家宁, 李蓉. MHR、NLR、PLR对急性脑卒中的预测研究[J]. 临床医学进展, 2023, 13(6): 9975-9979. https://doi.org/10.12677/ACM.2023.1361394

参考文献

[1] Asli, B., Seyda-Figul, G., Burhanettin, C., et al. (2017) Monocyte/High-Density Lipoprotein Ratio Predicts the Mortality in Ischemic Stroke Patients. Neurologia i Neurochirurgia Polska, 52, 150-155. [Google Scholar] [CrossRef] [PubMed]
[2] Wang, W., Jiang, B., Sun, H., et al. (2017) Prevalence, Incidence, and Mortality of Stroke in China. Circulation, 135, 759-771. [Google Scholar] [CrossRef
[3] Rost, N.S., Brodtmann, A., Pase, M.P., et al. (2022) Post-Stroke Cognitive Impairment and Dementia. Circulation Research, 130, 1252-1271. [Google Scholar] [CrossRef
[4] Fassbender, K., Rossol, S., Kammer, T., Michael, D., Steffen, W., Martina, D. and Michael, H. (1994) Proinflammatory Cytokines in Serum of Patients with Acute Cerebral Ischemia: Kinetics of Secretion and Relation to the Extent of Brain Damage and Outcome of Disease. Journal of the Neurological Sciences, 122, 135-139. [Google Scholar] [CrossRef
[5] Jin, R., Yang, G. and Li, G. (2010) Inflammatory Mecha-nisms in Ischemic Stroke: Role of Inflammatory Cells. Journal of Leukocyte Biology, 87, 779-789. [Google Scholar] [CrossRef] [PubMed]
[6] Antonino, T., Domenico-Di, R., Rosaria, P., Arnao, V., Pinto, A. and Li-cata, G. (2012) Inflammation in Ischemic Stroke Subtypes. Current Pharmaceutical Design, 18, 4289-4310. [Google Scholar] [CrossRef] [PubMed]
[7] Ekeløf, S., Jensen, S.E., Rosenberg, J. and Gögenur, I. (2014) Reduced Oxidative Stress in STEMI Patients Treated by Primary Percutaneous Coronary Intervention and with Antioxi-dant Therapy: A Systematic Review. Cardiovascular Drugs and Therapy, 28, 173-181. [Google Scholar] [CrossRef] [PubMed]
[8] Stefano, S., Angela, A., Giuseppe, B., et al. (2020) Plate-let-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio and Monocyte-to-HDL Cholesterol Ratio as Markers of Pe-ripheral Artery Disease in Elderly Patients. International Journal of Molecular Medicine, 46, 1210-1216. [Google Scholar] [CrossRef] [PubMed]
[9] Sarejloo, S., Abadifard, E., Othman, Z.J., et al. (2022) Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis. Disease Markers, 2022, Article ID: 5911408. [Google Scholar] [CrossRef] [PubMed]
[10] Suh, B., Shin, D.W., Kwon, H.-M., Yun, J.M., Yang, H.-K., Ahn, E., Lee, H., Park, J.H. and Cho, B. (2017) Elevated Neutrophil to Lymphocyte Ratio and Ischemic Stroke Risk in Generally Healthy Adults. PLOS ONE, 12, e0183706. [Google Scholar] [CrossRef] [PubMed]
[11] Viers, B.-R., Thompso, R.-H., Lohse, C.-M., Cheville, J.C., Leibovich, B.C., Boorjian, S.A. and Tollefson, M.K. (2016) Pre-Treatment Neutrophil-to-Lymphocyte Ratio Predicts Tumor Pathology in Newly Diagnosed Renal Tumors. World Journal of Urology, 34, 1693-1699. [Google Scholar] [CrossRef] [PubMed]
[12] Ao, L.-Y., Yan, Y.-Y., Zhou, L., Li, C., Li, W.-T., Fang, W. and Li, Y. (2018) Immune Cells after Ischemic Stroke Onset: Roles, Migration and Target Intervention. Journal of Molecular Neuroscience, 66, 342-355. [Google Scholar] [CrossRef] [PubMed]
[13] Seyed-Esmaeil, K., William, W., Maryam, F., Yaghoob, F. and Hadi, F.M. (2017) Pathogenic Mechanisms Following Ischemic Stroke. Neurological Sciences, 38, 1167-1186. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, H., Zhan, F. and Wang, Y. (2020) Evaluation of Mono-cyte-to-High-Density Lipoprotein Cholesterol Ratio and Monocyte-to-Lymphocyte Ratio in Ischemic Stroke. The Journal of International Medical Research, 48. [Google Scholar] [CrossRef] [PubMed]
[15] Hansson, G.-K., Libby, P., Schönbeck, U., et al. (2002) Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis. Circulation Research, 91, 281-291. [Google Scholar] [CrossRef
[16] Kazmierski, R., Guzik, P., Ambrosius, W., Ciesielska, A., Moskal, J. and Kozubski, W. (2004) Predictive Value of White Blood Cell Count on Admission for In-Hospital Mortality in Acute Stroke Patients. Clinical Neurology and Neurosurgery, 107, 38-43. [Google Scholar] [CrossRef] [PubMed]
[17] Gwendalyn, J. (2014) Mechanisms That Regulate Macrophage Burden in Atherosclerosis. Circulation Research, 114, 1757-1771. [Google Scholar] [CrossRef
[18] Nagao, M., Nakajima, H., Toh, R., et al. (2018) Cardio-protective Effects of High-Density Lipoprotein Beyond Its Anti-Atherogenic Action. Journal of Atherosclerosis and Thrombosis, 25, 985-993. [Google Scholar] [CrossRef
[19] Karabacak, M., Kahraman, F., Sert, M., et al. (2015) Increased Plasma Monocyte Chemoattractant Protein-1 Levels in Patients with Isolated Low High-Density Lipo-protein Cholesterol. Scandinavian Journal of Clinical and Laboratory Investigation, 75, 327-332. [Google Scholar] [CrossRef] [PubMed]
[20] Hafiane, A. and Genest, J. (2015) High Density Lipoproteins: Measurement Techniques and Potential Biomarkers of Cardiovascular Risk. BBA Clinical, 3, 175-188. [Google Scholar] [CrossRef] [PubMed]
[21] Zhang, Y.Z., Zanotti, I., Reilly, M.-P., et al. (2003) Overexpres-sion of Apolipoprotein A-I Promotes Reverse Transport of Cholesterol from Macrophages to feces in Vivo. Circulation, 108, 661-663. [Google Scholar] [CrossRef
[22] Murphy, A.J., Woollard, K.J., Hoang, A., et al. (2008) High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response. Arteriosclerosis, Thrombosis and Vascular Biology, 28, 2071-2077. [Google Scholar] [CrossRef
[23] 程静. NLR、MHR、PLR在急性脑梗死患者早期临床预测意义[D]: [硕士学位论文]. 张家口: 河北北方学院, 2021.
[24] Xu, Q., Wu, Q., Chen, L., et al. (2023) Monocyte to High-Density Lipoprotein Ratio Predicts Clinical Outcomes after Acute Ischemic Stroke or Transient Ischemic Attack. CNS Neuroscience & Therapeutics, 1-12. [Google Scholar] [CrossRef] [PubMed]
[25] Omar, T., Karakayal, M., Yesin, M., et al. (2021) Monocyte to High-Density Lipoprotein Cholesterol Ratio Is Associated with the Presence of Carotid Artery Disease in Acute Ischemic Stroke. Biomarkers in Medicine, 15, 489-495. [Google Scholar] [CrossRef] [PubMed]
[26] Zhai, M., Cao, S., Wang, X., et al. (2023) Correction: Increased Neutrophil-to-Lymphocyte Ratio Is Associated with Unfavorable Functional Outcomes in Acute Pontine Infarction. BMC Neurology, 23, Article No. 51. [Google Scholar] [CrossRef] [PubMed]
[27] Zhang, R., Wu, X., Hu, W., Zhao, L., Zhao, S., Zhang, J., Chu, Z. and Xu, Y. (2019) Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in ischemic Stroke: A Me-ta-Analysis. Brain and Behavior, 9, e01382. [Google Scholar] [CrossRef] [PubMed]
[28] Tokgoz, S., Kayrak, M., Akpinar, Z., et al. (2013) Neutrophil Lymphocyte Ratio as a Predictor of Stroke. Journal of Stroke and Cerebrovascular Diseases, 22, 1169-1174. [Google Scholar] [CrossRef] [PubMed]
[29] Sun, Y.-Y., Wang, M.-Q., Wang, Y., et al. (2022) Platelet-to-Lymphocyte Ratio at 24h after Thrombolysis Is a Prognostic Marker in Acute Ischemic Stroke Patients. Fron-tiers in Immunology, 13, Article 1000626. [Google Scholar] [CrossRef] [PubMed]
[30] 方明昊, 钱伟东. 平均血小板体积/淋巴细胞比值对急性脑梗死严重程度的预测价值[J]. 蚌埠医学院学报, 2021, 46(5): 591-594.
[31] 阿加尔∙木合大, 玛依拉∙吐尔逊, 罗东辉. 中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对急性脑梗死患者预后的预测价值研究[J]. 临床和实验医学杂志, 2023, 22(1): 12-15.