成年女性出生体重与血脂相关性研究

Association between Birth Weight and Blood Lipid in Healthy Female Adults

摘要: 目的：本研究拟分析成年女性出生体重与血脂之间的相关性，为血脂异常及心血管危险因素预防提供参考。方法：研究对象为2020年1月~2022年5月在济宁医学院附属医院体检中心健康体检的本院职工，共计87例。收集研究人群出生体重、年龄、身高、体重、腰围、空腹血糖、肝肾功能，以及血脂指标包括甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白–胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)，并计算体重指数(BMI)。采用Pearson相关分析及多元线性逐步回归分析探究出生体重与各血脂指标之间的相关性。结果：单因素分析结果显示出生体重与TC (相关系数：0.274，P = 0.010)、HDL-c (相关系数：0.225，P = 0.036)及LDL-c (相关系数：0.235，P = 0.029)均呈正相关关系，而与TG之间无明显相关性(P = 0.638)。进一步多因素回归分析显示，在分别调整相关混杂因素后，出生体重与TC (标准化系数：0.234，P = 0.022)及HDL-c (标准化系数：0.250，P = 0.014)之间呈独立正相关关系。结论：本研究结果显示在健康成年女性人群中，出生体重与血脂指标TC及HDL-c独立相关，未来关于出生体重与血脂异常及心血管危险因素之间的关系尚需进一步研究证实。

Abstract: Objectives: This study aimed to analyze the association between birth weight and blood lipid in healthy female adults, so as to provide consult for dyslipidemia and cardiovascular risk factors prevention. Methods: The subjects were 87 employees who underwent physical examinations at the Medical Examination Center of Affiliated Hospital of Jining Medical University from January 2020 to May 2022. The birth weight, age, height, weight, waist circumference, fasting blood glucose, liver and kidney function, and blood lipid indicators including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were collected. Body mass index (BMI) was calculated. Pearson correlation and multiple linear stepwise regression analyses were used to explore the correlation between birth weight and various blood lipid indicators. Results: The univariate analysis showed that birth weight was positively correlated with TC (correlation coefficient: 0.274, P = 0.010), HDL-c (correlation coefficient: 0.225, P = 0.036) and LDL-c (correlation coefficient: 0.235, P = 0.029), but there was no significant correlation with TG (P = 0.638). Furthermore, multivariate regression analysis showed that after adjusting for con-founding factors, there were independent positive relationships between birth weight and TC (standardized coefficient: 0.234, P = 0.022) and HDL-c (standardized coefficient: 0.250, P = 0.014). Conclusion: The results of this study show significant positive relationships between birth weight and blood lipid indicators including TC and HDL-c in healthy female adults. Further research is needed to confirm the relationship between birth weight and blood lipid abnormalities and cardio-vascular risk factors.