芍药苷在呼吸系统疾病中的作用研究进展
Research Progress on the Role of Paeoniflorin in Respiratory Diseases
DOI: 10.12677/ACM.2023.1361400, PDF,    国家自然科学基金支持
作者: 宋允龙, 张楠楠, 郭茂青, 武 薇*:济宁医学院临床学院,山东 济宁
关键词: 芍药苷抗炎慢阻肺哮喘肺纤维化肺损伤肺部感染Paeoniflorin Anti-Inflammatory COPD Asthma Pulmonary Fibrosis Lung Injury Pulmonary Infection
摘要: 芍药苷(Paeoniflorin, PF)是一种从毛莨科植物芍药中纯化的生物活性化合物,具有抗炎、抗氧化、免疫调节等作用。目前已有众多学者发现芍药苷在抗炎这一领域有着广阔的研究前景。而呼吸系统疾病的发生与进展,常与机体炎症因子的过度分泌有密切关联,因此,本文对芍药苷抗炎作用在呼吸系统疾病中的研究进展进行综述。
Abstract: Paeoniflorin (PF) is a bioactive compound purified from hairy family peony with anti-inflamma- tory, antioxidant, immunomodulatory effects. At present, many scholars have found that paeoniflorin has a broad research prospect in the field of anti-inflammation. The occurrence and progression of res-piratory diseases are often closely related to the transition secretion of inflammatory factors in the body. Therefore, the research progress of the anti-inflammatory effect of paeoniflorin in respiratory diseases is reviewed.
文章引用:宋允龙, 张楠楠, 郭茂青, 武薇. 芍药苷在呼吸系统疾病中的作用研究进展[J]. 临床医学进展, 2023, 13(6): 10016-10021. https://doi.org/10.12677/ACM.2023.1361400

参考文献

[1] 冯伟科, 郭平. 芍药苷药理作用研究进展[J]. 山东中医杂志, 2019, 38(1): 105-108. [Google Scholar] [CrossRef
[2] 谭丹, 曾小琴, 徐伟, 等. 芍药苷对慢性阻塞性肺疾病的疗效分析[J]. 中华肺部疾病杂志(电子版), 2019, 12(2): 160-165.
[3] Lin, J., Xu, F., Wang, G., Kong, L., Luo, Q., Lv, Y., et al. (2016) Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine, 2016, Article ID: 1698379. [Google Scholar] [CrossRef] [PubMed]
[4] Li, J., Ma, J., Tian, Y., Zhao, P., Liu, X., Dong, H., et al. (2020) Effec-tive-Component Compatibility of Bufei Yishen Formula II Inhibits Mucus Hypersecretion of Chronic Obstructive Pul-monary Disease Rats by Regulating EGFR/PI3K/mTOR Signaling. Journal of Ethnopharmacology, 257, Article ID: 112796. [Google Scholar] [CrossRef] [PubMed]
[5] 金颖, 李宜丹. 芍药内酯苷对OVA诱导哮喘小鼠气道炎症作用的研究[J]. 饮食保健, 2020, 7(22): 70.
[6] 刘家齐, 赵正晓, 魏颖, 等. 芍药苷对哮喘模型小鼠气道炎症趋化因子及受体的干预作用[J]. 中国实验动物学报, 2016, 24(5): 460-464. [Google Scholar] [CrossRef
[7] 端瑾, 滕媛媛, 杜莹莹. 芍药苷对哮喘小鼠炎症的作用及其机制研究[J]. 江苏科技信息, 2021, 38(19): 60-64. [Google Scholar] [CrossRef
[8] 刘家齐, 魏颖, 杜鑫, 等. 芍药苷对卵蛋白诱导的哮喘小鼠气道炎症的影响[J]. 老年医学与保健, 2015, 21(3): 178-180. [Google Scholar] [CrossRef
[9] Zhou, H., Wu, Q., Wei, L. and Peng, S. (2018) Paeoniflorin Inhibits PDGF-BB-Induced Human Airway Smooth Muscle Cell Growth and Migration. Molecular Medicine Reports, 17, 2660-2664. [Google Scholar] [CrossRef] [PubMed]
[10] Shou, Q., Jin, L., Lang, J., Shan, Q., Ni, Z., Cheng, C., Li, Q., Fu, H. and Cao, G. (2019) Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mecha-nism Underlying Paeoniflorin for the Treatment of Allergic Asthma. Frontiers in Pharmacology, 9, Article No. 1531. [Google Scholar] [CrossRef] [PubMed]
[11] Ji, Y., Wang, T., Wei, Z.F., Lu, G.X., Jiang, S.D., Xia, Y.F. and Dai, Y. (2013) Paeoniflorin, the Main Active Constituent of Paeonia lactiflora Roots, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing the Synthesis of Type I Collagen. Journal of Ethnopharmacology, 149, 825-832. [Google Scholar] [CrossRef] [PubMed]
[12] Ji, Y., Dou, Y.N., Zhao, Q.W., Zhang, J.Z., Yang, Y., Wang, T., Xia, Y.F., Dai, Y. and Wei, Z.F. (2016) Paeoniflorin Suppresses TGF-β Mediated Epithelial-Mesenchymal Transition in Pulmonary Fibrosis through a Smad-Dependent Pathway. Acta Pharmacologica Sinica, 37, 794-804. [Google Scholar] [CrossRef] [PubMed]
[13] Yu, W., Zeng, M., Xu, P., Liu, J. and Wang, H. (2021) Effect of Paeoni-florin on Acute Lung Injury Induced by Influenza A Virus in Mice. Evidences of Its Mechanism of Action. Phytomedi-cine, 92, Article ID: 153724. [Google Scholar] [CrossRef] [PubMed]
[14] Szarka, R.J., Wang, N., Gordon, L., Nation, P.N. and Smith, R.H. (1997) A Murine Model of Pulmonary Damage Induced by Lipopolysaccharide via Intranasal Instillation. The Journal of Immunological Methods, 202, 49-57. [Google Scholar] [CrossRef
[15] 张斌, 李红梅, 王媛, 等. 芍药苷减轻小鼠LPS性急性肺损伤的作用机制研究[J]. 中国病理生理杂志, 2011, 27(10): 1956-1960. [Google Scholar] [CrossRef
[16] 凌林, 佟晶, 曾良. 芍药苷通过激活Nrf2/Keap1信号通路改善脓毒症急性肺损伤的研究[J]. 四川大学学报(医学版), 2020, 51(5): 664-669. [Google Scholar] [CrossRef] [PubMed]
[17] Ngamsri, K.C., Wagner, R., Vollmer, I., Stark, S. and Reutershan, J. (2010) Adenosine Receptor A1 Regulates Polymorphonuclear Cell Trafficking and Microvascular Permeability in Lipo-polysaccharide-Induced Lung Injury. The Journal of Immunology, 185, 4374-4384. [Google Scholar] [CrossRef] [PubMed]
[18] 王再亮, 孔辉, 曾晓宁, 等. 活性氧介导脂多糖联合三磷酸腺苷诱导的人肺动脉内皮细胞炎症小体活化[J]. 南京医科大学学报(自然科学版), 2015, 35(7): 968-974.
[19] 黄燕华, 华檬, 崔学范. 芍药苷减弱真菌葡聚糖诱导的支气管上皮细胞内NLRP3炎性小体活化[J]. 南京医科大学学报(自然科学版), 2017, 37(3): 287-292. [Google Scholar] [CrossRef
[20] Qian, W., Zhang, J., Wang, W., Wang, T., Liu, M., Yang, M., Sun, Z., Li, X. and Li, Y. (2020) Antimicrobial and Antibiofilm Activities of Paeoniflorin against Carbapenem-Resistant Klebsiella pneumoniae. Journal of Applied Microbiology, 128, 401-413. [Google Scholar] [CrossRef] [PubMed]
[21] Mohamed, A., Chen, Y., Wu, H., Liao, J., Cheng, B. and Lu, Q. (2019) Therapeutic Advances in the Treatment of SLE. International Immunopharmacology, 72, 218-223. [Google Scholar] [CrossRef] [PubMed]
[22] Basta, F., Fasola, F., Triantafyllias, K. and Schwarting, A. (2020) Systemic Lupus Erythematosus (SLE) Therapy: The Old and the New. Rheumatology and Therapy, 7, 433-446. [Google Scholar] [CrossRef] [PubMed]
[23] Ji, L., Hou, X., Liu, W., Deng, X., Jiang, Z., Huang, K. and Li, R. (2018) Paeoniflorin Inhibits Activation of the IRAK1-NF-κB Signaling Pathway in Peritoneal Macrophages from Lupus-Prone MRL/lpr Mice. Microbial Pathogenesis, 124, 223-229. [Google Scholar] [CrossRef] [PubMed]