COPD-OSAHS重叠综合征患者的相关研究进展
Correlational Research Progress in Patients with COPD-OSAHS Overlap Syndrome
摘要: 阻塞性睡眠呼吸暂停低通气综合和慢性阻塞性肺疾病代表着成年人群中高度普遍存在的主要健康问题，两者均为呼吸系统常见的慢性疾病，当两种疾病出现在同一患者时称为OSAHS-COPD重叠综合征，其至少影响1%的人群。但到目前为止，OS特殊的临床特征并未得到很好地描述，临床对于重叠综合征的诊断也仅仅是通过COPD或者是OSAHS诊断标准来识别，还有目前存在绝大多数呼吸健康专业人员及临床医师团队对OS仍未有充分的认识，使得重叠综合征的漏诊与误诊率只升不降。
Abstract: Obstructive sleep apnea hypopnea syndrome and chronic obstructive pulmonary disease represent major health problems that are highly prevalent in the adult population. Both of them are common chronic diseases of the respiratory system. When the two diseases appear in the same patient, they are called OSAHS-COPD overlap syndrome, which affects at least 1% of the population. However, so far, the special clinical characteristics of OS have not been well described, and the clinical diagnosis of OS is only identified by COPD or OSAHS diagnostic criteria. In addition, most respiratory health professionals and clinical physician teams have not fully understood OS, which makes the missed diagnosis and misdiagnosis rate of overlap syndrome only rise.
文章引用：刘淑宪, 华毛. COPD-OSAHS重叠综合征患者的相关研究进展[J]. 临床医学进展, 2023, 13(6): 10022-10028. https://doi.org/10.12677/ACM.2023.1361401

参考文献

[1] Singh, D., Agusti, A., Anzueto, A., et al. (2019) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019. European Respiratory Journal, 53, Ar-ticle ID: 1900164. [Google Scholar] [CrossRef] [PubMed]
[2] 《慢性阻塞性肺疾病诊治指南(2021年修订版)》诊断要点[J]. 实用心脑肺血管病杂志, 2021, 29(6): 134.
[3] Wang, C., Xu, J., Yang, L., et al. (2018) Prev-alence and Risk Factors of Chronic Obstructive Pulmonary Disease in China (the China Pulmonary Health [CPH] Study): A National Cross-Sectional Study. The Lancet, 391, 1706-1717. [Google Scholar] [CrossRef] 
[4] Fang, L., Gao, P., Bao, H., et al. (2018) Chronic Obstructive Pulmonary Disease in China: A Nationwide Prevalence Study. The Lancet Respiratory Medicine, 6, 421-430. [Google Scholar] [CrossRef] 
[5] Edwards, B.A., Eckert, D.J. and Jordan, A.S. (2016) Ob-structive Sleep Apnoea Pathogenesis from Mild to Severe: Is It All the Same? Respirology, 22, 33-42. [Google Scholar] [CrossRef] [PubMed]
[6] Buist, A.S., Mcburnie, M.A., Vollmer, W.M., et al. (2007) International Variation in the Prevalence of COPD (the BOLD Study): A Population-Based Prevalence Study. The Lancet, 370, 741-750. [Google Scholar] [CrossRef] 
[7] Flenley, D.C. (1985) Sleep in Chronic Obstructive Lung Disease. Clinics in Chest Medicine, 6, 651-661. [Google Scholar] [CrossRef] 
[8] Marques, R.D., Berton, D.C., Domnik, N.J., et al. (2021) Sleep Quality and Architecture in COPD: The Relationship with Lung Function Abnormalities. Jornal brasileiro de pneumologia: Publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 47, e20200612. [Google Scholar] [CrossRef] [PubMed]
[9] Shawon, M., Perret, J.L., Senaratna, C.V., et al. (2017) Cur-rent Evidence on Prevalence and Clinical Outcomes of Co-Morbid Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review. Sleep Medicine Reviews, 32, 58-68. [Google Scholar] [CrossRef] [PubMed]
[10] Zhang, P., et al. (2022) Predictors and Outcomes of Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease in China. BMC Pulmonary Medicine, 22, Article No. 16. [Google Scholar] [CrossRef] [PubMed]
[11] Steveling, E.H., Clarenbach, C.F., Miedinger, D., et al. (2014) Predictors of the Overlap Syndrome and Its Association with Comorbidities in Patients with Chronic Obstructive Pul-monary Disease. Respiration, 88, 451-457. [Google Scholar] [CrossRef] [PubMed]
[12] Hu, W.H., et al. (2020) Obstructive Sleep Apnea Increases the Prevalence of Hypertension in Patients with Chronic Obstructive Disease. COPD: Journal of Chronic Obstructive Pulmonary Dis-ease, 17, 523-532. [Google Scholar] [CrossRef] [PubMed]
[13] Xiong, M.Q., Hu, W.H., Hu, K., et al. (2019) Analysis of Risk Factors and Consequences for Concurrent Obstructive Sleep Apnea in Chronic Obstructive Pulmonary Disease Pa-tients. Chinese Journal of Tuberculosis and Respiratory Diseases, 42, 832-837.
[14] Soler, X., Liao, S.Y., Marin, J.M., et al. (2017) Age, Gender, Neck Circumference, and Epworth Sleepiness Scale Do Not Predict Obstructive Sleep Apnea (OSA) in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD): The Challenge to Predict OSA in Ad-vanced COPD. PLOS ONE, 12, e0177289. [Google Scholar] [CrossRef] [PubMed]
[15] Peppard, P.E., Young, T., Palta, M., et al. (2000) Longitudinal Study of Moderate Weight Change and Sleep-Disordered Breathing. JAMA, 284, 3015-3021. [Google Scholar] [CrossRef] [PubMed]
[16] Mcnicholas, W.T. (2017) COPD-OSA Overlap Syndrome: Evolv-ing Evidence Regarding Epidemiology, Clinical Consequences, and Management. Chest, 152, 1318-1326.
[17] Teodorescu, M., et al. (2009) Predictors of Habitual Snoring and Obstructive Sleep Apnea Risk in Pa-tients with Asthma. Chest, 135, 1125-1132. [Google Scholar] [CrossRef] [PubMed]
[18] Mcnicholas, W.T. and Crinion, S.J. (2014) Sleep-Related Disorders in Chronic Obstructive Pulmonary Disease. Expert Review of Respiratory Medicine, 8, 79-88.
[19] 熊梦清. 慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停临床特征及危险因素分析[D]: [硕士学位论文]. 武汉: 武汉大学, 2019.
[20] 徐立新, 冯唐贵, 胡珍. 老年COPD患者并发阻塞性睡眠呼吸暂停低通气综合征的危险因素分析[J]. 中国现代医生, 2020, 58(32): 8-10+14.
[21] Zhang, X.L., Gao, B., Han, T., et al. (2020) Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD. Inter-national Journal of COPD, 15, 1813-1822. [Google Scholar] [CrossRef] 
[22] Wang, Y., Li, B., Li, P., et al. (2020) Severe Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease Is Associated with an Increased Prevalence of Mild Cognitive Impairment. Sleep Medicine, 75, 522-530. [Google Scholar] [CrossRef] [PubMed]
[23] Zhang, X.L., Dai, H.P., Zhang, H., et al. (2019) Obstructive Sleep Apnea in Patients with Fibrotic Interstitial Lung Disease and COPD. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 15, 1807-1815. [Google Scholar] [CrossRef] [PubMed]
[24] Voulgaris, A., Nena, E. and Steiropoulos, P. (2018) Comment on: Comor-bidities in Coexisting Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea-Overlap Syndrome. Euro-pean Review for Medical and Pharmacological Sciences, 22, 6171-6172.
[25] Nicholas-Tiberio, E., Ioannis, I., Lemonia, V., et al. (2018) Sleepiness, Fatigue, Anxiety and Depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea-Overlap-Syndrome, before and after Continuous Positive Airways Pressure Therapy. PLOS ONE, 13, e0197342. [Google Scholar] [CrossRef] [PubMed]
[26] Dan, A., Bailly, S., Benmerad, M., et al. (2020) Clinical Presentation and Comorbidities of Obstructive Sleep Apnea-COPD Overlap Syndrome. PLOS ONE, 15, e0235331. [Google Scholar] [CrossRef] [PubMed]
[27] Clímaco, D.C.S., et al. (2022) Sleep Quality in COPD Patients: Correlation with Disease Severity and Health Status. Jornal Brasileiro de Pneumologia, 48, e20210340.
[28] Clímaco, D.C.S., et al. (2023) Is Obstructive Sleep Apnea Associated with Increased Arterial Stiffness in Patients with COPD? Sleep and Breathing, 27, 765-770.
[29] Zhao, Z., Zhang, D., Sun, H., et al. (2022) Anxiety and Depression in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea: The Overlap Syn-drome. Sleep and Breathing, 26, 1603-1611. [Google Scholar] [CrossRef] [PubMed]
[30] Lvarez, D., Sánchez-Fernández, A., Andrés-Blanco, A., et al. (2019) Influence of Chronic Obstructive Pulmonary Disease and Moderate-to-Severe Sleep Apnoea in Overnight Cardiac Autonomic Modulation: Time, Frequency and Non-Linear Analyses. Entropy, 21, Article No. 381. [Google Scholar] [CrossRef] [PubMed]
[31] Mungo, P.F.D., Lopes, P.F., Almeida, A.M., et al. (2018) The Triad of Obstructive Sleep Apnea Syndrome, COPD, and Obesity: Sensitivity of Sleep Scales and Respiratory Questionnaires. Jornal Brasileiro De Pneumologia, 44, 202-206. [Google Scholar] [CrossRef] [PubMed]
[32] Yang, X., Tang, X., Cao, Y., et al. (2020) The Bronchiectasis in COPD-OSA Overlap Syndrome Patients. International Jour-nal of COPD, 15, 605-611. [Google Scholar] [CrossRef] 
[33] Archontogeorgis, K., et al. (2018) Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnea Syndrome and Concurrent Chronic Obstructive Pulmonary Disease. Clinical and Applied Thrombosis/Hemostasis, 24, 1216-1222.
[34] Spicuzza, L., Campisi, R., Crimi, C., et al. (2019) Prevalence and Determinants of Co-Morbidities in Patients with Obstructive Ap-nea and Chronic Obstructive Pulmonary Disease. European Journal of Internal Medicine, 69, e15-e16. [Google Scholar] [CrossRef] [PubMed]
[35] Jaoude, P. and El-Solh, A.A. (2019) Predictive Factors for COPD Exacerbations and Mortality in Patients with Overlap Syndrome. The Clinical Respiratory Journal, 13, 643-651. [Google Scholar] [CrossRef] [PubMed]
[36] Schreiber, A., Surbone, S., Malovini, A., et al. (2018) The Effect of Contin-uous Positive Airway Pressure on Pulmonary Function May Depend on the Basal Level of Forced Expiratory Volume in 1 Second. Journal of Thoracic Disease, 10, 6819-6827. [Google Scholar] [CrossRef] [PubMed]
[37] Ferrer-Lluis, I., et al. (2021) Sleep Apnea & Chronic Obstructive Pulmonary Disease: Overlap Syndrome Dynamics in Patients from an Epidemiological Study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2021, 5574-5577.
[38] Sami, R., Hashemi, S. and Jalilolghadr, S. (2021) Polysomnography Findings of Patients with Overlap Syndrome According to Severity of Lower Airway Obstruction. Journal of Research in Medical Sciences, 26, Article No. 130.
[39] Zhu, J., et al. (2020) Effect of Lung Function on the Apnea-Hypopnea Index in Patients with Overlap Syndrome: A Multicenter Cross-Sectional Study. Sleep and Breathing, 24, 1059-1066.
[40] Putcha, N., Crain-iceanu, C., Norato, G., et al. (2016) Influence of Lung Function and Sleep-Disordered Breathing on All-Cause Mortality. A Community-Based Study. American Journal of Respiratory and Critical Care Medicine, 194, 1007-1014. [Google Scholar] [CrossRef] 
[41] 关巍, 格日力. 高原环境对呼吸系统疾病的影响[J]. 中华医学杂志, 2015, 95(30): 2491-2493.
[42] 张爱华, 杨春艳, 张俊图. OSAHS的中医研究进展[J]. 云南中医中药杂志, 2012, 33(11): 69-72.
[43] Pham, L.V., et al. (2017) Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders. High Altitude Medicine & Biology, 18, 11-19.
[44] 杨生岳, 冯恩志, 闫自强, 等. 高原地区慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停低通气综合征患者的随访结果分析[J]. 中华肺部疾病杂志: 电子版, 2012, 5(1): 4-10.
[45] 宋翊飒. 高原地区重叠综合征患者肺功能和血氧饱和度的临床分析[C]//中华医学会第七次全国高原医学学术会议暨中国病理生理学会第九次全国缺氧和呼吸病理生理学术会议论文集. 2014: 55-56.
[46] Voulgaris, A., Archontogeorgis, K., Nena, E., et al. (2019) Burden of Comorbidities in Patients with OSA and COPD-OSA Overlap Syndrome. European Respiratory Journal, 54, PA905. [Google Scholar] [CrossRef] 
[47] Kendzerska, T., et al. (2018) Cardiovascular Out-comes and All-Cause Mortality in Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease (Overlap Syndrome). Annals of the American Thoracic Society, 16, 71-81. [Google Scholar] [CrossRef] 
[48] Castañ-Abad, M., Josep, M.C., Pere, G., et al. (2020) Diabetes as a Risk Factor for Severe Exacerbation and Death in Patients with COPD: A Prospective Cohort Study. Eu-ropean Journal of Public Health, 30, 822-827. [Google Scholar] [CrossRef] [PubMed]
[49] Katsiki, N., Steiropoulos, P., Papanas, N., et al. (2021) Diabetes Melli-tus and Chronic Obstructive Pulmonary Disease: An Overview. Experimental and Clinical Endocrinology & Diabetes, 129, 699-704.
[50] Zhou, W., Li, C., Cao, J., et al. (2020) Metabolic Syndrome Prevalence in Patients with Obstructive Sleep Apnea Syndrome and Chronic Obstructive Pulmonary Disease: Relationship with Systemic Inflammation. The Clinical Respiratory Journal, 14, 1159-1165.
[51] Archontogeorgis, K., et al. (2020) Metabolic Syndrome in Patients with Coexistent Obstructive Sleep Apnea Syndrome and Chronic Obstructive Pulmonary Disease (Overlap Syndrome). Metabolic Syndrome and Related Disorders, 18, 296-301. [Google Scholar] [CrossRef] [PubMed]
[52] Lacedonia, D., Carpagnano, G.E., Patricelli, G., et al. (2018) Prevalence of Comorbidities in Patients with Obstructive Sleep Apnea Syndrome, Overlap Syndrome and Obesity Hypoventilation Syndrome. The Clinical Respiratory Journal, 12, 1905-1911.

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