血清化验指标对脑出血生存预测中的价值研究
Study on the Value of Serum Laboratory Indicators in Predicting Survival of Cerebral Hemorrhage
DOI: 10.12677/ACM.2023.1361404, PDF,   
作者: 张盼娟:青海大学临床医学院,青海 西宁;金俐明*:青海大学附属医院,急诊内科,青海 西宁
关键词: 炎症指标凝血指标脑出血Inflammatory Indicators Coagulation Indicators Intracerebral Hemorrhage
摘要: 脑出血的发病机制与病情进展过程中,炎症反应及凝血功能异常可能参与到脑出血的继发性脑损伤过程中。其指标是影响脑出血预后的重要因素,多种血清生化指标可参与其中。本文对炎症指标,如:白细胞、中性粒细胞与淋巴细胞百分比、白细胞介素-6、C反应蛋白、肿瘤坏死因子-α、及凝血指标,如纤维蛋白原、D-二聚体与脑出血患者生存的相关性及预测的效能进行综述。
Abstract: The pathogenesis and progression of cerebral hemorrhage may involve inflammatory reactions and abnormal coagulation function in the secondary brain injury process of cerebral hemorrhage. Its indicators are important factors affecting the prognosis of cerebral hemorrhage, and multiple se-rum biochemical indicators can be involved. This article focuses on inflammatory indicators such as white blood cells, percentage of neutrophils and lymphocytes, interleukin-6, C-reactive protein, and tumor necrosis factor-α, and reviews the correlation and predictive efficacy of coagulation indicators such as fibrinogen and D-dimer with survival in patients with cerebral hemorrhage.
文章引用:张盼娟, 金俐明. 血清化验指标对脑出血生存预测中的价值研究[J]. 临床医学进展, 2023, 13(6): 10044-10049. https://doi.org/10.12677/ACM.2023.1361404

参考文献

[1] 蒋令修, 梁宇, 孙永梅, 等. 脑出血后外周血白细胞计数变化与预后的相关性研究[J]. 中国实用神经疾病杂志, 2017, 20(15): 12-15.
[2] He, J.L., Zhang, Y., Cheng, X., et al. (2023) White Blood Cell Count Predicts Mortality in Patients with Spontaneous Intracerebral Hemorrhage. Neurocritical Care. [Google Scholar] [CrossRef] [PubMed]
[3] 郑翼, 白丛霞, 何森, 等. 外周血白细胞计数与脑卒中患者全因死亡的相关性研究[J]. 实用医院临床杂志, 2017, 14(4): 128-132.
[4] 徐磊, 古红香, 李兴义, 等. IL-18、NLR和NLRP3水平与高血压性脑出血严重程度及预后的关系[J]. 分子诊断与治疗志, 2022, 14(10): 1765-1769.
[5] Li, L., Zhang, H. and Feng, G.L. (2022) Neutrophil-to-Lymphocyte Ratio Predicts in-Hospital Mortal-ity in Intracerebral Hemorrhage. Journal of Stroke and Cerebrovascular Diseases: The Official Journal of National Stroke Association, 31, Article ID: 106611. [Google Scholar] [CrossRef] [PubMed]
[6] Atillasoy, J., Leasure, A.C., Schwartz, A., et al. (2022) Abstract TP134: Association of Neutrophil-Lymphocyte Ratio with Functional Outcome in Spontaneous Intrac-erebral Hemorrhage. Stroke, 53, ATP134. [Google Scholar] [CrossRef
[7] 崔大勇, 王新, 张博. 血清及脑脊液NLRP3、PCT、CRP水平对脑出血微创穿刺术后颅内感染的诊断价值[J]. 中国实验诊断学, 2020, 24(3): 421-423.
[8] 周洪霞, 娄宁, 魏子峰, 等. 大鼠脑出血后血肿周围脑水肿及其与NF-κB和IL-6表达的关系[J]. 山东大学学报(医学版), 2012, 50(11): 30-33.
[9] Zhu, H., Wang, Z., Yu, J., et al. (2019) Role and Mechanisms of Cytokines in the Secondary Brain Injury after Intracerebral Hemorrhage. Progress in Neurobiology, 178, Article ID: 101610. [Google Scholar] [CrossRef] [PubMed]
[10] 廖鹏, 耿保伟, 张小翠, 等. 脑出血患者血清中IL-6和TNF-α水平与患者神经功能及脑水肿体积的关系[J]. 中华保健医学杂志, 2018, 20(5): 406-408.
[11] Silva, Y., Leira, R., Tejada, J., Lainez, J.M., Castillo, J., Dávalos A., and Stroke Project, Cerebrovascular Diseases Group of the Spanish Neurological Society (2005) Molecular Signatures of Vascular Injury Are Associated with Early Growth of In-tracerebral Hemorrhage. Stroke, 36, 86-91. [Google Scholar] [CrossRef
[12] Audrey, L.C., Lindsey, K.R., Kevin, V.N., et al. (2021) Association of Serum IL-6 (Interleukin 6) with Functional Outcome after Intracerebral Hemorrhage. Stroke, 52, 1733-1740. [Google Scholar] [CrossRef
[13] 陈琳, 周成芳, 梁江红. 高血压脑出血患者CRPIL-6水平及其临床意义[J]. 中国实用神经疾病杂志, 2016, 19(13): 39-41.
[14] 申松波, 胡胜, 吴星, 等. 脑出血患者血清hs-CRP、IL-6水平与脑出血量及神经功能损伤的相关性[J]. 神经损伤与功能重建, 2020, 15(11): 652-653, 680.
[15] 张维, 李少泉, 彭文龙, 等. 血清IL-6、TNF-α、MMP-9、CRP水平与高血压脑出血患者预后的相关性分析[J]. 解放军医药杂志, 2020, 32(3): 105-108.
[16] Starzer, A.M., Steindl, A., Mair, M.J., et al. (2021) Systemic Inflammation Scores Correlate with Survival Prognosis in Patients with Newly Diagnosed Brain Metastases. British Journal of Cancer, 124, 1294-1300. [Google Scholar] [CrossRef] [PubMed]
[17] 陈燕, 张秋, 尤年兴, 等. 急性缺血性脑卒中静脉溶栓后神经功能恢复及脑出血转化发生的影响因素分析[J]. 中华危重病急救医学, 2020, 32(11): 1340-1345.
[18] Lattanzi, S., Brigo, F., Trinka, E., et al. (2019) Neutrophil-to-Lymphocyte Ratio in Acute Cerebral Hemorrhage: A System Review. Translational Stroke Research, 10, 137-145. [Google Scholar] [CrossRef] [PubMed]
[19] 黄德庆, 高玉广, 邓海霞, 等. CRP、PCT及CCR5与急性脑出血预后的关系[J]. 西部医学, 2022, 34(6): 843-846.
[20] 李慕华, 陈康, 罗琨祥, 等. 炎症反应在脑出血后继发脑损伤的研究进展[J]. 右江医学, 2022, 50(10): 794-797.
[21] 刘思洋, 苏彬, 吴建龙, 等. 高血压脑出血患者血清TNF-α、IL-6及VEGF的表达及意义[J]. 河北医学, 2021, 27(9): 1460-1464.
[22] 贾丽娟, 李文强, 鱼丽萍. 脑出血患者外周血TLR4、TNF-α、IFN-γ水平与预后的关系[J]. 海南医学, 2019, 30(20): 2601-2603.
[23] 王玉亮, 赖少娟, 崔志新. 脑出血患者早期凝血功能的特点及其临床意义[J]. 甘肃医药, 2021, 40(3): 223-225.
[24] 李健英, 林建华. 联合检测Hcy、FIB、D-D对急性脑梗死患者的临床诊断意义研究[J]. 现代医用影像学, 2019, 28(5): 1059-1060.
[25] 何文杰, 王星南, 焦俊利, 等. 急性脑出血患者血浆FIB, FGF21表达水平变化及其与预后的关系[J]. 卒中与神经疾病, 2022, 29(6): 557-560.
[26] Vilar, R., Fish, R.J., Casini, A. and Neerman-Arbez, M. (2020) Fibrin (Ogen) in Human Disease: Both Friend and Foe. Haematologica, 105, 284-296. [Google Scholar] [CrossRef] [PubMed]
[27] Li, D., Xing, C., Li, Y. and Zhu, X.Y. (2020) Ele-vated Plasma Fibrinogen Indicates Short-Term Poor Outcome in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis. Journal of Stroke and Cerebrovascular Diseases, 29, Article ID: 104991. [Google Scholar] [CrossRef] [PubMed]
[28] Paulin, B.K., Cedric, K.K., Tamomh, A.G., et al. (2019) Assessment of Cardiac Biomarkers (Troponin, B-Type Natriuretic Peptide, and D-Dimer) in Patients with Non-Valvular Atrial Fibrillation and Stroke. International Journal of Health Sciences, 13, 3-12.
[29] 张丽侠, 马涛, 李荣利. 血液中NSE、D-D、Hcy在脑出血病情评估中的价值研究[J]. 中国急救复苏与灾害医学杂志, 2022, 17(10): 1318-1321.
[30] 赵呈进, 郭毅, 秦宣峰, 等. GCS评分联合D-二聚体对老年高血压脑出血病人生存率的预测价值[J]. 实用老年医学, 2021, 35(8): 855-856, 865.
[31] Zhou, Z., Liang, Y., Zhang, X., et al. (2018) Plasma D-Dimer Concentrations and Risk of Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis. Frontiers in Neurology, 9, Article 1114. [Google Scholar] [CrossRef] [PubMed]
[32] 吴波涛, 温安延, 徐学斌, 等. 血清IL-12、IL-27、CTRP-3、D-D水平与脑出血患者脑损伤的相关性分析[J]. 中华神经创伤外科电子杂志, 2019, 5(4): 196-200.