川贝母及其主要成分抗炎作用研究进展

Advances in the Study of Anti-Inflammatory Effects of Fritillariae cirrhosae Bulbus and Its Main Components

摘要: 背景：川贝母基源于百合科贝母属，常见于多种植物的干燥鳞茎，其主要活性成分为异甾体类生物碱，具有镇咳、抗炎、祛痰、镇痛、抗癌、抗氧化等多种功效。近年来，其抗炎作用越来越受到关注，成为炎症疾病防治的一个研究热点。目的：本文通过概述川贝母及其活性成分主要是贝母辛在哮喘、慢性阻塞性肺病、急性肺损伤疾病等中的治疗作用，以期为川贝母的进一步临床应用提供理论依据。方法：运用计算机检索中国知网、万方、PubMed、SinoMed数据库，对相关文献进行归纳整理与分析。检索的关键词为“川贝母、贝母辛、哮喘、急性肺损伤、慢性阻塞性肺病、癌症”。结果和结论：川贝母可以通过抑制JAK/STAT、MAPK等信号通路的激活，降低炎症因子和炎症细胞的聚集，从而起到抗炎作用。在炎症相关疾病中川贝母及其活性提取物的抗炎作用，具有多效应、多靶点、多信号通路的特点，且其具体作用机制较为复杂仍有待我们进一步探索。

Abstract: Background: Fritillariae cirrhosae Bulbus derived from the genus Fritillaria in the lily family and is commonly found on the dried bulbs of a variety of plants. Its main active ingredient is isosteric al-kaloids, which have various effects such as cough suppressant, anti-inflammatory, expectorant, an-algesic, anti-cancer and antioxidant. In recent years, its anti-inflammatory effects have received in-creasing attention and become a research hotspot in the prevention and treatment of inflammatory diseases. Objective: This paper provides a theoretical basis for the further clinical application of Fri-tillariae cirrhosae Bulbus and its active ingredients, mainly bemusine, in asthma, chronic obstruc-tive pulmonary disease and acute lung injury diseases by outlining their therapeutic effects. Meth-ods: We used the computer to search the databases of China Knowledge Network, Wanfang, PubMed and SinoMed to summarize and analyze the relevant literature. The keywords searched were “Fri-tillariae cirrhosae Bulbus, Peimisine, Asthma, Acute Lung Injury, COPD, Cancer”. Results and Con-clusions: Fritillariae cirrhosae Bulbus can reduce the aggregation of inflammatory factors and in-flammatory cells by inhibiting the activation of JAK/STAT, MAPK and other signaling pathways, thus exerting anti-inflammatory effects. The anti-inflammatory effects of Fritillariae cirrhosae Bulbus and its active extracts in inflammation-related diseases are characterized by multiple effects, mul-tiple targets and multiple signaling pathways, and their specific mechanisms of action are complex and still need to be further explored.