在骨折术后内植物感染中确定致病菌的相关研究

Correlative Study on the Identification of Pathogenic Bacteria in Implant Infection after Fracture Surgery

摘要: 术后内植物感染(Infection after fracture fixation, IAFF)是创伤骨科常见的并发症。因其临床症状多样、手术处理复杂、医疗费用高、治疗周期长等特征，给患者带来严重的经济负担和精神压力。因此，早期确定致病菌对于指导术后内植物感染的治疗意义重大，也是治愈疾病的关键所在。因此，微生物的准确检测是临床处理IAFF的关键，但受限于检测技术的手段和种植体表面生物膜的难以穿透，往往使临床上很难准确地检测到致病菌，药物也很难透过生物膜达到有效的治疗药物浓度。由于术后内植物感染疾病的复杂性、危害性和检测手段的有限性之间的矛盾，有必要对IAFF的检测手段作一系统梳理。国内的综述多以传统常规的检测方法为主，故本文对于新的临床常用的检测手段和方法作一综述。

Abstract: Infection after fracture fixation (IAFF) is a common complication in orthopedic trauma. Due to its various clinical symptoms, complicated surgical treatment, high medical costs, long treatment cycle and other characteristics, it brings serious economic burden and mental pressure to patients. Therefore, early identification of pathogenic bacteria is of great significance for guiding the treat-ment of postoperative plant infection, and is also the key to cure the disease. Therefore, accurate detection of microorganisms is the key to clinical treatment of IAFF. However, due to the limitations of detection techniques and impenetrability of implant surface biofilm, it is often difficult to accu-rately detect pathogenic bacteria in clinical practice, and it is difficult for drugs to achieve effective therapeutic drug concentration through biofilm. Due to the contradiction between the complexity and harmfulness of postoperative plant infection diseases and the limitation of detection methods, it is necessary to make a systematic review of detection methods of IAFF. Domestic reviews mainly focus on traditional conventional detection methods, so this paper reviews the new clinical detec-tion methods and methods.