HOTAIR在女性生殖系统疾病中的研究进展

Research Progress of HOTAIR in Female Reproductive System Diseases

摘要: 长链非编码RNA (Long non-coding RNAs, LncRNAs)是一类长度大于200个核苷酸序列且不显著表达蛋白质的RNA。LncRNA种类众多，例如HOTAIR、H19、PVT1、RMRP、SNHG8、NRCP等。越来越多研究表明，LncRNA参与了多种肿瘤(乳腺癌、肺癌、胃癌、淋巴瘤和胶质母细胞瘤等)的调控。HOX转录物反义基因间核糖核酸(HOTAIR)是一种长约2.2 kb核苷酸调节反式基因表达的LncRNA，是研究与人类疾病相关的最广泛的LncRNA之一。大量研究发现，HOTAIR在许多疾病的发生发展等方面都起到一定的作用，尤其是在女性生殖系统疾病中的病理生理发展过程中起到了重要的作用，例如卵巢癌、宫颈癌、子宫内膜癌、子宫内膜异位症、子宫肌瘤、多囊卵巢综合征等疾病，探讨HOTAIR在疾病中的作用机制，为进一步预防和治疗女性生殖系统疾病提供了新的思路。本篇综述主要就HOTAIR在女性生殖系统疾病中的作用机制研究的最新进展进行阐述。

Abstract: Long non-coding RNAs (LncRNAs) are RNA with a length of more than 200 nucleotides and no sig-nificant protein expression. There are many kinds of LncRNA, such as HOTAIR, H19, PVT1, RMRP, SNHG8, NRCP, etc. More and more studies show that LncRNA is involved in the regulation of a varie-ty of tumors (breast cancer, lung cancer, stomach cancer, lymphoma, glioblastoma, etc.). HOX tran-script antisense intergenic ribonucleic acid (HOTAIR) is an LncRNA with a length of approximately 2.2 kb that regulates the expression of trans genes. It is one of the most widely studied LncRNAs re-lated to human diseases. A large number of studies have found that HOTAIR plays a certain role in the occurrence and development of many diseases, especially in the pathological and physiological development of female reproductive system diseases, such as ovarian cancer, cervical cancer, en-dometrial cancer, endometriosis, uterine fibroids, polycystic ovary syndrome, and other diseases. To explore the mechanism of HOTAIR’s role in diseases, this provides new ideas for further preven-tion and treatment of female reproductive system diseases. This review mainly elaborates on the latest progress in the study of the mechanism of action of HOTAIR in female reproductive system diseases.